781 research outputs found
Hybrid quantum systems of atoms and ions
In recent years, ultracold atoms have emerged as an exceptionally
controllable experimental system to investigate fundamental physics, ranging
from quantum information science to simulations of condensed matter models.
Here we go one step further and explore how cold atoms can be combined with
other quantum systems to create new quantum hybrids with tailored properties.
Coupling atomic quantum many-body states to an independently controllable
single-particle gives access to a wealth of novel physics and to completely new
detection and manipulation techniques. We report on recent experiments in which
we have for the first time deterministically placed a single ion into an atomic
Bose Einstein condensate. A trapped ion, which currently constitutes the most
pristine single particle quantum system, can be observed and manipulated at the
single particle level. In this single-particle/many-body composite quantum
system we show sympathetic cooling of the ion and observe chemical reactions of
single particles in situ.Comment: ICAP proceeding
Cold heteronuclear atom-ion collisions
We study cold heteronuclear atom ion collisions by immersing a trapped single
ion into an ultracold atomic cloud. Using ultracold atoms as reaction targets,
our measurement is sensitive to elastic collisions with extremely small energy
transfer. The observed energy-dependent elastic atom-ion scattering rate
deviates significantly from the prediction of Langevin but is in full agreement
with the quantum mechanical cross section. Additionally, we characterize
inelastic collisions leading to chemical reactions at the single particle level
and measure the energy-dependent reaction rate constants. The reaction products
are identified by in-trap mass spectrometry, revealing the branching ratio
between radiative and non-radiative charge exchange processes
Observation of photon-assisted tunneling in optical lattices
We have observed tunneling suppression and photon-assisted tunneling of
Bose-Einstein condensates in an optical lattice subjected to a constant force
plus a sinusoidal shaking. For a sufficiently large constant force, the ground
energy levels of the lattice are shifted out of resonance and tunneling is
suppressed; when the shaking is switched on, the levels are coupled by
low-frequency photons and tunneling resumes. Our results agree well with
theoretical predictions and demonstrate the usefulness of optical lattices for
studying solid-state phenomena.Comment: 5 pages, 3 figure
Forecasting-Aided Monitoring for the Distribution System State Estimation
In this paper, an innovative approach based on an artificial neural network (ANN) load forecasting model to improve the distribution system state estimation accuracy is proposed. High-quality pseudomeasurements are produced by a neural model fed with both exogenous and historical load information and applied in a realistic measurement scenario. Aggregated active and reactive powers of small or medium enterprises and residential loads are simultaneously predicted by a one-step ahead forecast. The correlation between the forecasted real and reactive power errors is duly kept into account in the definition of the estimator together with the uncertainty of the overall measurement chain. The beneficial effects of the ANN-based pseudomeasurements on the quality of the state estimation are demonstrated by simulations carried out on a small medium-voltage distribution grid
The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease
Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e., HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the main etiological agents of genital tract cancers, such as cervical, vulvar, vaginal, penile, and anal cancers, and of a subset of head and neck cancers. Three prophylactic HPV vaccines are available that are bivalent (vs. HPV16, 18), tetravalent (vs. HPV6, 11, 16, 18), and non-avalent (vs. HPV6, 11, 16, 18, 31, 33,45, 52, 58). All of these vaccines are based on recombinant DNA technology, and they are prepared from the purified L1 protein that self-assembles to form the HPV type-specific empty shells (i.e., virus-like particles). These vaccines are highly immunogenic and induce specific antibodies. Therapeutic vaccines differ from prophylactic vaccines, as they are designed to generate cell-mediated immunity against transformed cells, rather than neutralizing antibodies. Among the HPV proteins, the E6 and E7 oncoproteins are considered almost ideal as targets for immunotherapy of cervical cancer, as they are essential for the onset and evolution of malignancy and are constitutively expressed in both premalignant and invasive lesions. Several strategies have been investigated for HPV therapeutic vaccines designed to enhance CD4+ and CD8+ T-cell responses, including genetic vaccines (i.e., DNA/ RNA/virus/ bacterial), and protein-based, peptide-based or dendritic-cell-based vaccines. However, no vaccine has yet been licensed for therapeutic use. Several studies have suggested that administration of prophylactic vaccines immediately after surgical treatment of CIN2 cervical lesions can be considered as an adjuvant to prevent reactivation or reinfection, and other studies have described the relevance of prophylactic vaccines in the management of genital warts. This review summarizes the leading features of therapeutic vaccines, which mainly target the early oncoproteins E6 and E7, and prophylactic vaccines, which are based on the L1 capsid protein. Through an analysis of the specific immunogenic properties of these two types of vaccines, we discuss why and how prophylactic vaccines can be effective in the treatment of HPV-related lesions and relapse
Controllable diffusion of cold atoms in a harmonically driven and tilted optical lattice: Decoherence by spontaneous emission
We have studied some transport properties of cold atoms in an accelerated
optical lattice in the presence of decohering effects due to spontaneous
emission. One new feature added is the effect of an external AC drive. As a
result we obtain a tunable diffusion coefficient and it's nonlinear enhancement
with increasing drive amplitude. We report an interesting maximum diffusion
condition.Comment: 16 pages, 7 figures, revised versio
Engineered quantum tunnelling in extended periodic potentials
Quantum tunnelling from a tilted, but otherwise periodic potential is
studied. Our theoretical and experimental results show that, by controlling the
system's parameters, we can engineer the escape rate of a Bose-Einstein
condensate to an exceptional degree. Possible applications of this atom-optics
realization of the open Wannier-Stark system are discussed.Comment: 6 pp, proceedings DICE 11-15 September 2006, Castello di Piombino,
Tuscany, Ital
AC-induced superfluidity
We argue that a system of ultracold bosonic atoms in a tilted optical lattice
can become superfluid in response to resonant AC forcing. Among others, this
allows one to prepare a Bose-Einstein condensate in a state associated with a
negative effective mass. Our reasoning is backed by both exact numerical
simulations for systems consisting of few particles, and by a theoretical
approach based on Floquet-Fock states.Comment: Accepted for publication in Europhysics letters, 6 pages, 4 figures,
Changes in v2: reference 7 replaced by a more recent on
Human Papillomavirus infections in cervical samples from HIV-positive women: evaluation of the presence of the nonavalent HPV genotypes and genetic diversity
Non-nonavalent vaccine (9v) Human papillomavirus (HPV) types have been shown to have high prevalence among HIV-positive women. Here, 1444 cervical samples were tested for HPV DNA positivity. Co-infections of the 9v HPV types with other HPV types were evaluated. The HPV81 L1 and L2 genes were used to investigate the genetic variability of antigenic epitopes. HPV-positive samples were genotyped using the HPVCLART2 assay. The L1 and L2 protein sequences were analyzed using a self-optimized prediction method to predict their secondary structure. Co-occurrence probabilities of the 9v HPV types were calculated. Non9v types represented 49% of the HPV infections; 31.2% of the non9v HPV types were among the low-grade squamous intraepithelial lesion samples, and 27.3% among the high-grade squamous intraepithelial lesion samples, and several genotypes were low risk. The co-occurrence of 9v HPV types with the other genotypes was not correlated with the filogenetic distance. HPV81 showed an amino-acid substitution within the BC loop (N75Q) and the FGb loop (T315N). In the L2 protein, all of the mutations were located outside antigenic sites. The weak cross-protection of the 9v types suggests the relevance of a sustainable and effective screening program, which should be implemented by HPV DNA testing that does not include only high-risk types
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