2,538 research outputs found
Testing the predictive validity of the healthy eating index-2015 in the multiethnic cohort: Is the score associated with a reduced risk of all-cause and cause-specific mortality?
The Healthy Eating Index-2015 (HEI-2015) was created to assess conformance of dietary intake with the Dietary Guidelines for Americans (DGA) 2015â2020. We assessed the association between the HEI-2015 and mortality from all-cause, cardiovascular disease (CVD), and cancer in the Multiethnic Cohort (MEC). White, African American, Native Hawaiian, Japanese American, and Latino adults (n > 215,000) from Hawaii and California completed a quantitative food-frequency questionnaire at study enrollment. HEI-2015 scores were divided into quintiles for men and women. Radar graphs were used to demonstrate how dietary components contributed to HEI-2015 scores. Mortality was documented over 17â22 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox proportional hazards models. High HEI-2015 scores were inversely associated with risk of mortality from all-cause, CVD, and cancer for men and women (p-trend <0.0001 for all models). For men, the HRs (CIs) for all-cause, CVD, and cancer comparing the highest to the lowest quintile were 0.79 (0.76, 0.82), 0.76 (0.71, 0.82), and 0.80 (0.75, 0.87), respectively. For women, the HRs were 0.79 (0.76, 0.82), 0.75 (0.70, 0.81), and 0.84 (0.78, 0.91), respectively. These results, in a multiethnic population, demonstrate that following a diet aligned with the DGAs 2015â2020 recommendations is associated with lower risk of mortality from all-cause, CVD, and cancer
Transmission of Human Papillomavirus in Heterosexual Couples
Rate of transmission from penis to cervix was lower than that from cervix to penis; 13 different genotypes were sexually transmitted
Macroscopic Dynamics of Multi-Lane Traffic
We present a macroscopic model of mixed multi-lane freeway traffic that can
be easily calibrated to empirical traffic data, as is shown for Dutch highway
data. The model is derived from a gas-kinetic level of description, including
effects of vehicular space requirements and velocity correlations between
successive vehicles. We also give a derivation of the lane-changing rates. The
resulting dynamic velocity equations contain non-local and anisotropic
interaction terms which allow a robust and efficient numerical simulation of
multi-lane traffic. As demonstrated by various examples, this facilitates the
investigation of synchronization patterns among lanes and effects of on-ramps,
off-ramps, lane closures, or accidents.Comment: For related work see
http://www.theo2.physik.uni-stuttgart.de/helbing.htm
Long-lived states in synchronized traffic flow. Empirical prompt and dynamical trap model
The present paper proposes a novel interpretation of the widely scattered
states (called synchronized traffic) stimulated by Kerner's hypotheses about
the existence of a multitude of metastable states in the fundamental diagram.
Using single vehicle data collected at the German highway A1, temporal velocity
patterns have been analyzed to show a collection of certain fragments with
approximately constant velocities and sharp jumps between them. The particular
velocity values in these fragments vary in a wide range. In contrast, the flow
rate is more or less constant because its fluctuations are mainly due to the
discreteness of traffic flow.
Subsequently, we develop a model for synchronized traffic that can explain
these characteristics. Following previous work (I.A.Lubashevsky, R.Mahnke,
Phys. Rev. E v. 62, p. 6082, 2000) the vehicle flow is specified by car
density, mean velocity, and additional order parameters and that are
due to the many-particle effects of the vehicle interaction. The parameter
describes the multilane correlations in the vehicle motion. Together with the
car density it determines directly the mean velocity. The parameter , in
contrast, controls the evolution of only. The model assumes that
fluctuates randomly around the value corresponding to the car configuration
optimal for lane changing. When it deviates from this value the lane change is
depressed for all cars forming a local cluster. Since exactly the overtaking
manoeuvres of these cars cause the order parameter to vary, the evolution
of the car arrangement becomes frozen for a certain time. In other words, the
evolution equations form certain dynamical traps responsible for the long-time
correlations in the synchronized mode.Comment: 16 pages, 10 figures, RevTeX
Two-way multi-lane traffic model for pedestrians in corridors
We extend the Aw-Rascle macroscopic model of car traffic into a two-way
multi-lane model of pedestrian traffic. Within this model, we propose a
technique for the handling of the congestion constraint, i.e. the fact that the
pedestrian density cannot exceed a maximal density corresponding to contact
between pedestrians. In a first step, we propose a singularly perturbed
pressure relation which models the fact that the pedestrian velocity is
considerably reduced, if not blocked, at congestion. In a second step, we carry
over the singular limit into the model and show that abrupt transitions between
compressible flow (in the uncongested regions) to incompressible flow (in
congested regions) occur. We also investigate the hyperbolicity of the two-way
models and show that they can lose their hyperbolicity in some cases. We study
a diffusive correction of these models and discuss the characteristic time and
length scales of the instability
Peroral Endoscopic Myotomy in Diffuse Thickened Esophageal Wall in an Adolescent
Achalasia is an extremely rare pathology in children. Peroral endoscopic myotomy (POEM) is the gold standard for the surgical treatment of achalasia in adults, but only a limited number of cases of achalasia treatment using POEM in children have been published in the literature. Sometimes, high-resolution manometry signs of achalasia can mimic diffuse esophageal leiomyoma. This case report represents the first known successful performance of POEM on a 15-year-old female with diffuse thickening of the esophagus with signs and symptoms of achalasia and suspicion for Alport syndrome associated with diffuse esophageal leiomyoma
Innovation Networks Modeling within the Concept of Open Innovations
The urgency of the problem discussed in the article is caused by necessity to search for effective forms of innovation activities' implementation, providing a maximizing of innovative resources' impact by strengthening relationships between entities of the innovation process. The purpose of the article is to develop a model of innovation network, facilitating the acceleration of the diffusion of innovation by increasing its throughput capability and maximum use of the resources of the state innovation system. The leading approach to the study of this problem is the system approach, according to which the interaction of entities in the innovation process is considered as a complex mechanism of communications, ensuring the transformation of innovative ideas into marketable final product. In this paper, a model of innovation network, meeting the requirements of the concept of open innovation, based on the effect of increasing returns of resources is proposed and the mechanism and the necessary conditions for its functioning are described. The materials presented in the paper can be used to develop long-term development programs, both locally and at the regional and Federal levels, while building the innovative systems of the appropriate level and providing adequate conditions for their functioning.
Keywords: innovation, innovation network, an innovative system, throughput capability, the diffusion of innovations.
JEL Classifications: G14, L11, O31, O3
PREMIUM, a benchmark on the quantification of the uncertainty of the physical models in the system thermal-hydraulic codes: methodologies and data review
The objective of the Post-BEMUSE Reflood Model Input Uncertainty Methods (PREMIUM) benchmark is to progress on the issue of the quantification of the uncertainty of the physical models in system thermalhydraulic codes by considering a concrete case: the physical models involved in the prediction of core reflooding. The present document was initially conceived as a final report for the Phase I âIntroduction and Methodology Reviewâ of the PREMIUM benchmark. The objective of Phase I is to refine the definition of the benchmark and publish the available methodologies of model input uncertainty quantification relevant to the objectives of the benchmark. In this initial version the document was approved by WGAMA and has shown its usefulness during the subsequent phases of the project. Once Phase IV was completed, and following the suggestion of WGAMA members, the document was updated adding a few new sections, particularly the description of four new methodologies that were developed during this activity. Such developments were performed by some participants while contributing to PREMIUM progress (which is why this report arrives after those of other phases). After this revision the document title was changed to âPREMIUM methodologies and data reviewâ. The introduction includes first a chapter devoted to contextualization of the benchmark in nuclear safety research and licensing, followed by a description of the PREMIUM objectives. Next, a description of the Phases in which the benchmark is divided and its organization is explained. Chapter two consists of a review of the involvement of the different participants, making a brief explanation of the input uncertainty quantification methodologies used in the activity. The document ends with some conclusions on the development of Phase I, some more general remarks and some statements on the benefits of the benchmark, which can be briefly summarized as it follows:
- Contribution to development of tools and experience related to uncertainty calculation and promotion of the use of BEPU approaches for licensing and safety assessment purposes;
- Contribution to prioritization of improvements to thermal-hydraulic system codes;
- Contribution to a fluent and close interaction between the scientific community and regulatory organizations.
Appendices include the complete description of the experimental data FEBA/SEFLEX used in the benchmark and the methodologies CIRCĂ and FFTBM and the general requirements and description specification used for Phase I. Due to the revision of the document, four extra appendixes have been added related to the methods developed during the activity, MCDA DIPE, Tractebel IUQ and PSI methods
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