7 research outputs found
Non-equilibrium theory of the allele frequency spectrum
A forward diffusion equation describing the evolution of the allele frequency
spectrum is presented. The influx of mutations is accounted for by imposing a
suitable boundary condition. For a Wright-Fisher diffusion with or without
selection and varying population size, the boundary condition is , where is the frequency
spectrum of derived alleles at independent loci at time and is
the relative population size at time . When population size and selection
intensity are independent of time, the forward equation is equivalent to the
backwards diffusion usually used to derive the frequency spectrum, but the
forward equation allows computation of the time dependence of the spectrum both
before an equilibrium is attained and when population size and selection
intensity vary with time. From the diffusion equation, we derive a set of
ordinary differential equations for the moments of and express the
expected spectrum of a finite sample in terms of those moments. We illustrate
the use of the forward equation by considering neutral and selected alleles in
a highly simplified model of human history. For example, we show that
approximately 30% of the expected heterozygosity of neutral loci is
attributable to mutations that arose since the onset of population growth in
roughly the last years.Comment: 24 pages, 7 figures, updated to accomodate referees' suggestions, to
appear in Theoretical Population Biolog
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Application of the t-model of optimal prediction to the estimation of the rate of decay of solutions of the Euler equations in two and three dimensions
The "t-model" for dimensional reduction is applied to the estimation of the rate of decay of solutions of the Burgers equation and of the Euler equations in two and three space dimensions. The model was first derived in a statistical mechanics context, but here we analyze it purely as a numerical tool and prove its convergence. In the Burgers case the model captures the rate of decay exactly, as was already previously shown. For the Euler equations in two space dimensions, the model preserves energy as it should. In three dimensions, we find a power law decay in time and observe a temporal intermittency
Non-equilibrium theory of the allele frequency spectrum. Submitted Available from http://www.stat.berkeley.edu/users/evans/705.pdf
Abstract. A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condition. For a Wright-Fisher diffusion with or without selection and varying population size, the boundary condition is limx↓0 xf(x, t) =θρ(t), where f(·,t) is the frequency spectrum of derived alleles at independent loci at time t and ρ(t) is the relative population size at time t. When population size and selection intensity are independent of time, the forward equation is equivalent to the backwards diffusion usually used to derive the frequency spectrum, but the forward equation allows computation of the time dependence of the spectrum both before an equilibrium is attained and when population size and selection intensity vary with time. From the diffusion equation, we derive a set of ordinary differential equations for the moments of f(·,t) and express the expected spectrum of a finite sample in terms of those moments. We illustrate the use of the forward equation by considering neutral and selected alleles in a highly simplified model of human history. For example, we show that approximately 30 % of the expected heterozygosity of neutral loci is attributable to mutations that arose since the onset of population growth in roughly the last 150, 000 years. 1