The Potential Involvement of E-cadherin and β-catenins in Meningioma

To investigate the potential involvements of E-cadherin and β-catenin in meningioma.Immunohistochemistry staining was performed on samples from patients with meningioma. The results were graded according to the positive ratio and intensity of tissue immunoreactivity. The expression of E-cadherin and β-catenin in meningioma was analyzed by its relationship with WHO2007 grading, invasion, peritumoral edema and postoperative recurrence.The positive rates of E-cadherin in meningioma WHO I, II, III were 92.69%, 33.33% and 0, respectively, (P<0.05); while the positive rates of β-catenin in meningioma WHO I, II, III were 82.93%, 33.33% and 20.00%, respectively, (P<0.05). The positive rate of E-cadherin in meningioma without invasion (94.12%) was higher than that with invasion (46.67%) (P<0.05). The difference in the positive rate of β-catenin between meningioma without invasion (88.24%) and meningioma with invasion (33.33%, P<0.05) was also statically significant. The positive rates of E-cadherin in meningioma with peritumoral edema 0, 1, 2, 3 were 93.75%, 85.71%, 60.00% and 0 respectively, (P<0.05); the positive rates of β-catenin in meningioma with peritumoral edema 0, 1, 2, 3 were 87.50%, 85.71%, 30.00% and 0 respectively, (P<0.01). The positive rates of E- cadherin in meningioma with postoperative recurrence were 33.33%, and the positive rate with postoperative non-recurrence was 90.00% (P<0.01). The positive rates of β-catenin in meningioma with postoperative recurrence and non-recurrence were 11.11%, 85.00%, respectively (P<0.01).The expression levels of E- cadherin and β-catenin correlated closely to the WHO 2007 grading criteria for meningioma. In atypical or malignant meningioma, the expression levels of E-cadherin and β-catenin were significantly lower. The expression levels of E- cadherin and β-catenin were also closely correlated with the invasion status of meningioma, the size of the peritumoral edema and the recurrent probabilities of the meningioma, all in an inverse correlationship. Taken together, the present study provided novel molecular targets in clinical treatments to meningioma

Evaluation of Geometrical Influence on the Hydrodynamic Characteristics and Power Absorption of Vertical Axisymmetric Wave Energy Converters in Irregular Waves

To obtain the mechanical energy of waves from arbitrary directions, the vibration absorbers of wave energy converters (WEC) are usually vertically axisymmetric. In such case, the wave-body interaction hydrodynamics is an essential research topic to obtain high-efficiency wave energy. In this paper, a semi-analytical method of decomposing the complex axisymmetric boundary into several ring-shaped stepped surfaces based upon the boundary approximation method (BAM) is introduced and examined. The hydrodynamic loads and parameters, such as the wave excitation forces, added mass and radiation damping of the vertical axisymmetric oscillating buoys, can then be achieved by using the new boundary discretisation method. The calculations of the wave forces and hydrodynamic coefficients show good convergence with the number of discretisation increases. Comparison between the constringent results and the results of the conventional method also verifies the feasibility of the method. Then, simulations and comparisons of the hydrodynamic forces, motions and wave power conversions of the buoys with series draught and displacement ratios in regular and irregular waves are conducted. The calculation results show that the geometrical shape has a great effect on the hydrodynamic and wave power conversion performance of the absorber. In regular waves, though the concave buoy has the lowest wave conversion efficiency, it has the largest frequency bandwidth for a given draught ratio, while in irregular waves, for a given draught ratio, the truncated cylindrical buoy has the best wave power conversion, and for a given displacement of the buoy, the concave buoy shows the best wave power conversion ability

Medulla oblongata hemorrhage after acupuncture: A case report and review of literature

Secondary hemorrhage occurs as a complication of central nervous system (CNS) following acupuncture has been reported in few cases. The present study reports a case of a 70-year-old woman who presents medulla oblongata hemorrhage after acupuncture. The patient suffered severe headache, neck pain, vomiting, and weakness after the neck acupuncture. The purpose of presenting this case report is to raise awareness among clinicians of fateful CNS complications during acupuncture. More importantly, qualified training of acupuncturists is anticipated and standardized processes of clinical acupuncture operations needs to be developed, in order to avoid the occurrence of acupuncture accidents. Keywords: Secondary hemorrhage, Medulla oblongata, Acupuncture, Complicatio

Dual-Chirp Photonics-Based Radar for Distance and Velocity Measurement Based on Compressive Sensing

We proposed a dual-chirp microwave photonic radar based on compressive sensing for distance and velocity measurement. This radar can generate different chirp linear frequency modulated (LFM) signals using a dual-parallel Mach-Zehnder modulator (DPMZM). In the receiving part, a dual-drive Mach-Zehnder modulator (DDMZM) and a Mach-Zehnder modulator (MZM) are cascaded for the optical mixing and de-chirp processing with a pseudo-random bit sequence (PRBS). Then the mixed signal can be gathered by an analog-to-digital converter (ADC) at a sampling rate that is well below the Nyquist sampling rate. Using fewer sampling points, the reconstruction algorithm can recover the de-chirped signal accurately with a compression ratio of 8. A proof-of-concept experiment demonstrates that when the target is stationary, the distance measurement error is about 1.560 cm. The signal-to-noise ratio (SNR) of the recovery signal is enhanced to 30.725 dB. When the target is moving, the simulation results present that the maximum distance error is 1.2 cm, and the velocity error is below 0.140 m/s. This compressive sensing radar reduces the pressure of a massive amount of data storage or processing and guarantees the accuracy of signal recovery. At the same time, it breaks the limitation of operation bandwidth and increases the speed of operation

Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

Neurological diseases, which consist of acute injuries and chronic neurodegeneration, are the leading causes of human death and disability. However, the pathophysiology of these diseases have not been fully elucidated, and effective treatments are still lacking. Astaxanthin, a member of the xanthophyll group, is a red-orange carotenoid with unique cell membrane actions and diverse biological activities. More importantly, there is evidence demonstrating that astaxanthin confers neuroprotective effects in experimental models of acute injuries, chronic neurodegenerative disorders, and neurological diseases. The beneficial effects of astaxanthin are linked to its oxidative, anti-inflammatory, and anti-apoptotic characteristics. In this review, we will focus on the neuroprotective properties of astaxanthin and explore the underlying mechanisms in the setting of neurological diseases

Creación de la población PQUI-1 desarrollada con tolerancia a frío mediante selección recurrente en arroz = PQUI-1 rice population developed with cold tolerance by recurrent selection

<p>Expression level was determined as ++.</p

The expression levels of E-cadherin and β-catenin with the postoperative recurrence of meningioma.

<p>The expression levels of E-cadherin and β-catenin with the postoperative recurrence of meningioma.</p

Nucleation and Assembly of Silica into Protein-Based Nanocomposites as Effective Anticancer Drug Carriers Using Self-Assembled Silk Protein Nanostructures as Biotemplates

<i>Bombyx mori</i> (<i>B.</i> <i>mori</i>) silk fibroin and sericin can act as a great candidate in delivering drugs or other bioactive substances. Silica also has a great application in the field of drug delivery. To the best of our knowledge, there has been no report on the design of a nanocomposite made of silk protein and silica for drug delivery. Here, for the first time, we used <i>B.</i> <i>mori</i> silk fibroin (SF) and sericin (SS), self-assembled into nanospheres and nanofibers in situ in the aqueous solution, respectively, as a biotemplate to regulate the nucleation and self-assembly of silica for designing anticancer drug delivery. SF and SS mediated the nucleation and assembly of silica into monodispersed nanospheres (termed Si/SF) and nanofibers (termed Si/SS), respectively. The size and topography of the silica assemblies were dependent on the concentration of SF or SS as well as reaction conditions. Both Si/SF nanospheres and Si/SS nanofibers showed a high loading capability and sustained release profile of an anticancer drug, doxorubicin (DOX), in vitro. Si/SF nanospheres were found to be efficiently internalized in human cervical carcinoma (HeLa) cells and accumulate around the cell nuclei. Si/SS nanofibers could only adhere to the surface of the cancer cells. This indicates that DOX-loaded Si/SF nanospheres and Si/SS nanofibers are more effective in cancer therapy than free DOX. Our results suggest that the self-assembled Si/SF spheres and Si/SS nanofibers are potential effective anticancer drug carriers