Human Sensation of Transcranial Electric Stimulation.

Noninvasive transcranial electric stimulation is increasingly being used as an advantageous therapy alternative that may activate deep tissues while avoiding drug side-effects. However, not only is there limited evidence for activation of deep tissues by transcranial electric stimulation, its evoked human sensation is understudied and often dismissed as a placebo or secondary effect. By systematically characterizing the human sensation evoked by transcranial alternating-current stimulation, we observed not only stimulus frequency and electrode position dependencies specific for auditory and visual sensation but also a broader presence of somatic sensation ranging from touch and vibration to pain and pressure. We found generally monotonic input-output functions at suprathreshold levels, and often multiple types of sensation occurring simultaneously in response to the same electric stimulation. We further used a recording circuit embedded in a cochlear implant to directly and objectively measure the amount of transcranial electric stimulation reaching the auditory nerve, a deep intercranial target located in the densest bone of the skull. We found an optimal configuration using an ear canal electrode and low-frequency (<300 Hz) sinusoids that delivered maximally ~1% of the transcranial current to the auditory nerve, which was sufficient to produce sound sensation even in deafened ears. Our results suggest that frequency resonance due to neuronal intrinsic electric properties need to be explored for targeted deep brain stimulation and novel brain-computer interfaces

A review of clinical use of surface-enhanced Raman scattering-based biosensing for glioma

Glioma is the most common malignant tumor of the nervous system in recent centuries, and the incidence rate of glioma is increasing year by year. Its invasive growth and malignant biological behaviors make it one of the most challenging malignant tumors. Maximizing the resection range (EOR) while minimizing the impact on normal brain tissue is crucial for patient prognosis. Changes in metabolites produced by tumor cells and their microenvironments might be important indicators. As a powerful spectroscopic technique, surface-enhanced Raman scattering (SERS) has many advantages, including ultra-high sensitivity, high specificity, and non-invasive features, which allow SERS technology to be widely applied in biomedicine, especially in the differential diagnosis of malignant tumor tissues. This review first introduced the clinical use of responsive SERS probes. Next, the sensing mechanisms of microenvironment-responsive SERS probes were summarized. Finally, the biomedical applications of these responsive SERS probes were listed in four sections, detecting tumor boundaries due to the changes of pH-responsive SERS probes, SERS probes to guide tumor resection, SERS for liquid biopsy to achieve early diagnosis of tumors, and the application of free-label SERS technology to detect fresh glioma specimens. Finally, the challenges and prospects of responsive SERS detections were summarized for clinical use

(S)-2-Amino-1-(pyrrolidinium-2-ylmeth­yl)pyridinium dibromide

In the title compound, C10H17N3 2+·2Br−, the pyrrolidinium ring displays an envelope conformation, with the flap N atom lying 0.564 (6) Å from the mean plane of the remaining four C atoms. The attached methyl­ene C atom, which connects the pyrrolidinium ring and the 2-amino­pyridine group, is displaced from the plane of the four pyrrolidinium C atoms by 0.811 (8) Å in the same direction as the pyrrolidinium N atom. The amine N lies on the opposite side of this plane

(S)-1-(2-Ammonio-3-methyl­butyl)-1,2-dihydro­pyridin-2-iminium dibromide

In the title compound, C10H19N3 2+·2Br−, the plane of the three butyl C atoms nearest to the pyridine ring is almost perpendicular to the ring [dihedral angle = 84.80 (2)°]. The N atom of the ammonium group is displaced by 1.150 (8) Å from the plane of these three C atoms. The iminium N atom lies on the opposite side of this plane. The crystal structure is stabilized by hydrogen bonds between the N and Br atoms, as well as by inter­molecular C—H⋯Br inter­actions

HULL SHAPE OPTIMIZATION OF SMALL UNDERWATER VEHICLE BASED ON KRIGING-BASED RESPONSE SURFACE METHOD AND MULTI-OBJECTIVE OPTIMIZATION ALGORITHM

Small underwater vehicles have unique advantages in ocean exploration. The resistance and volume of a vehicle are key factors affecting its operation time underwater. This paper aims to develop an effective method to obtain the optimal hull shape of a small underwater vehicle using Kriging-based response surface method (RSM) and multi-objective optimization algorithm. Firstly, the hydrodynamic performance of a small underwater vehicle is numerically investigated using computational fluid dynamics (CFD) method and the value range of related design variables is determined. The mesh convergence is verified to ensure the accuracy of the calculation results. Then, by means of the Latin hypercube sampling (LHS) design of simulation, the Kriging-based RSM model is developed according to the relation between each design variable of the vehicle and the output parameters applied to the vehicle. Based on the Kriging-based RSM model, the optimal hull shape of the vehicle is determined by using Screening and MOGA. As results, the vehicle resistance reduces and volume increases obviously