Various Patterns of Japanese Hospital BSC Practices : A Tentative Classification.

1.はじめに 2.我が国における病院BSCの多様な実務例と特徴 2.1 済生会熊本病院の事例 2.2 聖路加国際病院の事例 2.3 東北大学病院地域医療連携センターの事例 2.4 敬愛会ちばなクリニックの事例 2.5 都立豊島病院看護科の事例 2.6 赤穂中央病院看護部の事例 2.7 旭中央病院外科の事例 2.8 栃木県立がんセンターの事例 2.9 川越胃腸科病院の事例 2.10 吉田病院臨床検査室の事例 2.11 東京医科大学病院中央検査部の事例 2.12 国立三重中央病院の事例 2.13 渓仁会の事例 2.14 横浜市都筑医療センター訪問看護ステーションの事例 2.15 三重県立病院の事例 3.まとめと今後の課題経済学部90周年記念論文集Essays in Commemoration of the 90th Anniversary of the Faculty of Economic

Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: analysis of a time-lapse live cell imaging system

<p>Reactive oxygen species induce neuronal cell death. However, the detailed mechanisms of cell death have not yet been elucidated. Previously, we reported neurite degeneration before the induction of cell death. Here, we attempted to elucidate the mechanisms of neurite degeneration before the induction of cell death using the neuroblastoma N1E-115 cell line and a time-lapse live cell imaging system. Treatment with the calcium ionophore ionomycin induced cell death and neurite degeneration in a concentration- and time-dependent manner. Treatment with a low concentration of ionomycin immediately produced a significant calcium influx into the intracellular region in N1E-115 cells. After 1-h incubation with ionomycin, the fluorescence emission of MitoSOX^TM increased significantly compared to the control. Finally, analysis using a new mitochondrial specific fluorescence dye, MitoPeDPP, indicated that treatment with ionomycin significantly increased the mitochondrial lipid hydroperoxide production in N1E-115 cells. The fluorescence emissions of Fluo-4 AM and MitoPeDPP were detected in the cell soma and neurite regions in ionomycin-treated N1E-115 cells. However, the emissions of neurites were much lower than those of the cell soma. TBARS values of ionomycin-treated cells significantly increased compared to the control. These results indicate that ionomycin induces calcium influx into the intracellular region and reactive oxygen species production in N1E-115 cells. Lipid hydroperoxide production was induced in ionomycin-treated N1E-115 cells. Calcium influx into the intracellular region is a possible activator of neurite degeneration.</p

我が国における病院BSC実務の多様性 : ケースレビューによる類型化の試み

1.はじめに 2.我が国における病院BSCの多様な実務例と特徴 2.1 済生会熊本病院の事例 2.2 聖路加国際病院の事例 2.3 東北大学病院地域医療連携センターの事例 2.4 敬愛会ちばなクリニックの事例 2.5 都立豊島病院看護科の事例 2.6 赤穂中央病院看護部の事例 2.7 旭中央病院外科の事例 2.8 栃木県立がんセンターの事例 2.9 川越胃腸科病院の事例 2.10 吉田病院臨床検査室の事例 2.11 東京医科大学病院中央検査部の事例 2.12 国立三重中央病院の事例 2.13 渓仁会の事例 2.14 横浜市都筑医療センター訪問看護ステーションの事例 2.15 三重県立病院の事例 3.まとめと今後の課題経済学部90周年記念論文集Essays in Commemoration of the 90th Anniversary of the Faculty of Economic