20 research outputs found
Brønsted Acid Ionic Liquids (BAILs) as Efficient and Recyclable Catalysts in the Conversion of Glycerol to Solketal at Room Temperature
Processing Parameter Effects on Residual Stress and Mechanical Properties of Selective Laser Melted Ti6Al4V
Selective laser melting (SLM) process is characterized by large temperature gradients resulting in high levels of residual stress within the additively manufactured metallic structure. SLM-processed Ti6Al4V yields a martensitic microstructure due to the rapid solidification and results in a ductility generally lower than a hot working equivalent. Post-process heat treatments can be applied to SLM components to remove in-built residual stress and improve ductility. Residual stress buildup and the mechanical properties of SLM parts can be controlled by varying the SLM process parameters. This investigation studies the effect of layer thickness on residual stress and mechanical properties of SLM Ti6Al4V parts. This is the first-of-its kind study on the effect of varying power and exposure in conjunction with keeping the energy density constant on residual stress and mechanical properties of SLM Ti6Al4V components. It was found that decreasing power and increasing exposure for the same energy density lowered the residual stress and improved the % elongation of SLM Ti6Al4V parts. Increasing layer thickness resulted in lowering the residual stress at the detriment of mechanical properties. The study is based on detailed experimental analysis along with finite element simulation of the process using ABAQUS to understand the underlying physics of the process
Efficient Isomerization of Glucose to Fructose over Zeolites in Consecutive Reactions in Alcohol and Aqueous Media.
Synthesis and Characterization of Ammonium-, Pyridinium-, and Pyrrolidinium-Based Sulfonamido Functionalized Ionic Liquids
Efficient Isomerization of Glucose to Fructose over Zeolites in Consecutive Reactions in Alcohol and Aqueous Media
Isomerization reactions of glucose
were catalyzed by different
types of commercial zeolites in methanol and water in two reaction
steps. The most active catalyst was zeolite Y, which was found to
be more active than the zeolites beta, ZSM-5, and mordenite. The novel
reaction pathway involves glucose isomerization to fructose and subsequent
reaction with methanol to form methyl fructoside (step 1), followed
by hydrolysis to re-form fructose after water addition (step 2). NMR
analysis with <sup>13</sup>C-labeled sugars confirmed this reaction
pathway. Conversion of glucose for 1 h at 120 °C with H‑USY
(Si/Al = 6) gave a remarkable 55% yield of fructose after the second
reaction step. A main advantage of applying alcohol media and a catalyst
that combines Brønsted and Lewis acid sites is that glucose is
isomerized to fructose at low temperatures, while direct conversion
to industrially important chemicals like alkyl levulinates is viable
at higher temperatures
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Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury
Pre-clinical models of traumatic brain injury (TBI) have been the primary experimental tool for understanding the potential mechanisms and cellular alterations that follow brain injury, but the human relevance and translational value of these models are often called into question. Efforts to better recapitulate injury biomechanics and the use of non-rodent species with neuroanatomical similarities to humans may address these concerns and promise to advance experimental studies toward clinical impact. In addition to improving translational aspects of animal models, it is also advantageous to establish pre-clinical outcomes that can be directly compared with the same outcomes in humans. Non-invasive imaging and particularly MRI is promising for this purpose given that MRI is a primary tool for clinical diagnosis and at the same time increasingly available at the pre-clinical level. The objective of this study was to identify which commonly used radiologic markers of TBI outcomes can be found also in a translationally relevant pre-clinical model of TBI. The ferret was selected as a human relevant species for this study with folded cortical geometry and relatively high white matter content and the closed head injury model of engineered rotation and acceleration (CHIMERA) TBI model was selected for biomechanical similarities to human injury. A comprehensive battery of MRI protocols based on common data elements (CDEs) for human TBI was collected longitudinally for the identification of MRI markers and voxelwise analysis of T2, contrast enhancement and diffusion tensor MRI values. The most prominent MRI findings were consistent with focal hemorrhage and edema in the brain stem region following high severity injury as well as vascular and meningeal injury evident by contrast enhancement. While conventional MRI outcomes were not highly conspicuous in less severe cases, quantitative voxelwise analysis indicated diffusivity and anisotropy alterations in the acute and chronic periods after TBI. The main conclusions of this study support the translational relevance of closed head TBI models in intermediate species and identify brain stem and meningeal vulnerability. Additionally, the MRI findings highlight a subset of CDEs with promise to bridge pre-clinical studies with human TBI outcomes. Copyright © 2022 Hutchinson, Romero-Lozano, Johnson, Knutsen, Bosomtwi, Korotcov, Shunmugavel, King, Schwerin, Juliano, Dardzinski and Pierpaoli.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]