Снежники Лагонакского нагорья (Западный Кавказ)

The article presents results of investigation of snowfields on the Lagonaky plateau: conditions of their formation, distribution and dynamics. Snow patches are the most characteristic elements of the high-mountain landscapes of the Lagonaky plateau. In warm seasons, they are widely distributed on local flat-topped ridges of the Lagonaky: Abadzeshsh Murzikao, Kamennoe and others, as well as on the mountain masses Fisht, Pshehasu, Oshten, and Nagoychuk. Morphological and climatic conditions of the Lagonaky Highlands are unique and favorable for formation of snow patches and long preservation of them during the spring-summer periods. These conditions are high mountain ridges with flat tops, negative karst forms of the relief as well as a favorable wind regime with long winter snow storms and heavy snowfalls. Snow patches result from snow transport and accumulation after strong snow-drift on the leeward slopes. The avalanche snow patches arise when avalanches release from steep and long slopes of the above mountain ranges. Permanent snow patches are usually formed at the same places, and duration of their existence depends on sizes and a degree of shading. At the same time, even relatively small snow patches (100–200 thousand m3) can be preserved if they are located in narrow fissures (for example, the area of the Maly Fisht Glacier). In the last 3–5 years, the permanent snow patches melt completely, which is probably a result of small amount of solid precipitation during the cold season and the relatively high air temperatures in the warm time (standard deviation is 0.8–1.0 °C above the normal).Представлены новые данные о снежниках Лагонакского нагорья. Проанализировано их распределение в пределах нагорья с учётом особенностей рельефа и ветрового режима. Отмечено значительное сокращение числа снежников и их размеров за последние годы, что обусловлено общей климатической тенденцией потепления

Современные методы терапии мышечной дистрофии Дюшенна: обзор литературы с клиническим примером

Duchenne muscular dystrophy is a genetic, X-linked, relentlessly progressive disease. Due to a genetic defect, the reading frame is disrupted during the synthesis of the dystrophin protein, resulting in its loss of functionality. As a result of the absence of dystrophin, there is a gradual destruction of muscle cells. In recent years, pathogenetic therapy for Duchenne muscular dystrophy has become available in Russia. However, the therapy available in Russia is specific, depending on the mutation variant, and may be recommended for approximately one third of patients. This article discusses the features of exon-skipping therapy, the clinical effectiveness, and safety of this group of drugs. The effectiveness and safety of the therapy are demonstrated through a clinical case of a patient receiving one of the drugs in this group.Прогрессирующая мышечная дистрофия Дюшенна – генетическое Х-сцепленное, неуклонно прогрессирующее заболевание. Вследствие генетической «поломки» нарушается рамка считывания при синтезе белка дистрофина, в результате чего он теряет функциональность. При отсутствии дистрофина происходит постепенное разрушение мышечных клеток. В последние несколько лет в России доступна патогенетическая терапия миодистрофии Дюшенна. Однако доступная в России терапия специфична, зависит от варианта мутации и может быть рекомендована примерно 1/3 пациентов. В настоящей статье приводятся особенности экзон-скиппинг-терапии, данные о клинической эффективности и безопасности этой группы препаратов. На клиническом примере пациента, получающего один из препаратов данной группы, демонстрируется эффективность и безопасность терапии

Fluid percussion injury device for the precise control of injury parameters

BackgroundInjury to the brain can occur from a variety of physical insults and the degree of disability can greatly vary from person to person. It is likely that injury outcome is related to the biomechanical parameters of the traumatic event such as magnitude, direction and speed of the forces acting on the head.New methodTo model variations in the biomechanical injury parameters, a voice coil driven fluid percussion injury (FPI) system was designed and built to generate fluid percussion waveforms with adjustable rise times, peak pressures, and durations. Using this system, pathophysiological outcomes in the rat were investigated and compared to animals injured with the same biomechanical parameters using the pendulum based FPI system.Results in comparison with existing methodsImmediate post-injury behavior shows similar rates of seizures and mortality in adolescent rats and similar righting times, toe pinch responses and mortality rates in adult rats. Interestingly, post injury mortality in adult rats was sensitive to changes in injury rate. Fluoro-Jade labeling of degenerating neurons in the hilus and CA2-3 hippocampus were consistent between injuries produced with the voice coil and pendulum operated systems. Granule cell population spike amplitude to afferent activation, a measure of dentate network excitability, also showed consistent enhancement 1 week after injury using either system.ConclusionsOverall our results suggest that this new FPI device produces injury outcomes consistent with the commonly used pendulum FPI system and has the added capability to investigate pathophysiology associated with varying rates and durations of injury

INTEGRATED MANAGEMENT INFORMATION AND TELEMATICS SYSTEMS OF TRANSPORT VEHICLES

The creation problem of management information and telematics systems of transport vehicles and transport systems is considered

Snow patches of the Lagonaky highlands (Western Caucasus)

The article presents results of investigation of snowfields on the Lagonaky plateau: conditions of their formation, distribution and dynamics. Snow patches are the most characteristic elements of the high-mountain landscapes of the Lagonaky plateau. In warm seasons, they are widely distributed on local flat-topped ridges of the Lagonaky: Abadzeshsh Murzikao, Kamennoe and others, as well as on the mountain masses Fisht, Pshehasu, Oshten, and Nagoychuk. Morphological and climatic conditions of the Lagonaky Highlands are unique and favorable for formation of snow patches and long preservation of them during the spring-summer periods. These conditions are high mountain ridges with flat tops, negative karst forms of the relief as well as a favorable wind regime with long winter snow storms and heavy snowfalls. Snow patches result from snow transport and accumulation after strong snow-drift on the leeward slopes. The avalanche snow patches arise when avalanches release from steep and long slopes of the above mountain ranges. Permanent snow patches are usually formed at the same places, and duration of their existence depends on sizes and a degree of shading. At the same time, even relatively small snow patches (100–200 thousand m3) can be preserved if they are located in narrow fissures (for example, the area of the Maly Fisht Glacier). In the last 3–5 years, the permanent snow patches melt completely, which is probably a result of small amount of solid precipitation during the cold season and the relatively high air temperatures in the warm time (standard deviation is 0.8–1.0 °C above the normal)

Digital medicine technologies for pre-trip medical examination of drivers

The technologies of automation of pre-trip integrated examination of the drivers’ conditions are considered, which make it possible to significantly improve the quality of control while reducing the time for its passage. A comparative analysis of known analogues is carried out, problems are formulated, the solution of which will increase the diagnostic efficiency of telemedicine examination. The configuration of the developed computer control system and the hardware-software structure of the subject’s control panel are described. The ways of increasing the reliability of user identification are considered. Technical means have been developed for non-contact thermometry and assessment of tremor parameters. Algorithms for assessing the physiological and psychoemotional state of drivers have been implemented