Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Classical Telugu poetry: an anthology

This groundbreaking anthology opens a window on a thousand years of classical poetry in Telugu, the mellifluous language of Andhra Pradesh in southern India. The classical tradition in Telugu is one of the richest yet least explored of all South Asian literatures. This authoritative volume, the first anthology of classical Telugu poetry in English, gives an overview of one of the world's most creative poetic traditions. Velcheru Narayana Rao and David Shulman have brought together mythological, religious, and secular texts by twenty major poets who wrote between the eleventh and nineteenth centuries. The beautifully translated selections are often dramatic and unexpected in tone and effect, and sometimes highly personal. The authors have provided an informative, engaging introduction, fleshing out the history of Telugu literature, situating its poets in relation to significant literary themes and historical developments, and discussing the relationship between Telugu and the classical literature and poetry of Sanskrit

When God is a customer: Telugu courtesan songs

How is it that this woman's breastsglimmer so clearly through her saree?Can't you guess, my friends?What are they but rays from the crescentsleft by the nails of her loverpressing her in his passion,rays now luminous as the moonlightof a summer night?These South Indian devotional poems show the dramatic use of erotic language to express a religious vision. Written by men during the fifteenth to eighteenth century, the poems adopt a female voice, the voice of a courtesan addressing her customer. That customer, it turns out, is the deity, whom the courtesan teases for his infidelities and cajoles into paying her more money. Brazen, autonomous, fully at home in her body, she merges her worldly knowledge with the deity's transcendent power in the act of making love.This volume is the first substantial collection in English of these Telugu writings, which are still part of the standard repertoire of songs used by classical South Indian dancers. A foreword provides context for the poems, investigating their religious, cultural, and historical significance. Explored, too, are the attempts to contain their explicit eroticism by various apologetic and rationalizing devices.The translators, who are poets as well as highly respected scholars, render the poems with intelligence and tenderness. Unusual for their combination of overt eroticism and devotion to God, these poems are a delight to read

Admission Preferences for Minority Students, Athletes, and Legacies at Elite Universities-super-

This study examines how preferences for different types of applicants exercised by admission offices at elite universities influence the number and composition of admitted students. Copyright (c) 2004 by the Southwestern Social Science Association.

Learning curves, taking instructions, and patient safety:using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors

PMID: 22967756 [PubMed - indexed for MEDLINE] PMCID: PMC3546877 Free PMC ArticlePeer reviewedPublisher PD