Swedana Samsakara of Haritaki (Terminalia chebula Retz) with Jala and Gomutra: A comparative Phyto-Pharmacognostical study

Samsakara (transformation) and Samyoga (combination) play major role in pharmaceutics. Samsakara is defined as Gunantaradhanam (transformation). Swedana is Agni Sannikarsha Samsakara. The changes in finished product because of Swedana Samsakara with two different media Jala and Gomutra can be perceived at pharmacognostical and phytochemical levels. Aims: To compare role of Swedana Samsakara with two different media Jala and Gomutra on basis of phyto-pharmacognostical, HPTLC and UV-VIS-NIR Reflectance (180-2500nm) study. Materials and Methods: In the present study, 3 samples were prepared viz. Haritaki Churna (Powder) (GH-1), Gomutra Swedita Haritaki(GH-3) and Jala Swedita Haritaki (GH-5), to compare role of Swedana Samsakara on basis of Pharmacognostical (powder microscopy), Pharmaceutical, HPTLC densitogram and UV-VIS-NIR reflectance (180-2500nm) study. Results: The samples prepared with different media showed difference in pharmacognostical, pharmaceutical, HPTLC and UV-VIS-NIR findings. Gomutra Swedita Haritaki(GH-3) had highest variation in all Phyto-Pharmacognostical, HPTLC and UV-VIS-NIR. Powder microscopy of GH-3 showed clumped epicarp cells, squashed mesocarp cells (not clear), parenchyma cells with brown content, cellular content was darker (brown) and crystalline material etc. Phytochemical parameters showed pH (7.0), loss on drying (9.303%w/w), ash value (15.84%w/w), water soluble extract (57.2%w/w), and alcohol soluble extract (43.5% w/w). HPTLC showed eight peaks at 256nm and 366nm. In UV-VIS-NIR, GH-3 has higher variation while other sample has higher leverage. GH-3 has apparent different profile from GH-1, GH-5. Conclusions: Swedana Samsakara effect was seen in both Jala and Gomutra but media (Samyoga) plays leading role to establish desired Gunas (qualities) and Karma (therapeutic action) in the final product.Â

Preclinical Evaluation of Safety and Biodistribution of Red Cell Microparticles: A Novel Hemostatic Agent

Uncontrollable bleeding is a major cause of mortality and morbidity worldwide. Effective hemostatic agents are urgently needed. Red cell microparticles (RMPs) are a highly promising hemostatic agent. This study evaluated the safety profile of RMPs preliminary to clinical trial. RMPs were prepared from type O+ human red blood cell by high-pressure extrusion. Male rats were treated with RMPs either a 1 × bolus, or 4 × or 20 × administered over 60 minutes. The vehicle-treated group was used as a control. Effects on physiological parameters were evaluated; namely, blood pressure, body and head temperature, hematocrit, and blood gases. We did not observe any adverse effects of RMPs on these physiological parameters. In addition, brain, heart, and lungs of rats treated with 4 × dose (bolus followed by infusion over 60 minutes) or vehicle were examined histologically for signs of thrombosis or other indications of toxicity. No thrombosis or indications of toxicity in brain, heart, or lungs were observed. Studies revealed that RMPs were distributed mainly in liver, spleen, and lymph nodes, and were potentially excreted through the kidneys. Our study indicates that RMP administration appears not to have any negative impact on the parameters studied and did not produce thrombosis in heart, brain, and lungs. However, more detailed long-term studies confirming the safety of RMP as a hemostatic agent are warranted

Proceedings of the International Conference on Frontiers in Desalination, Energy, Environment and Material Sciences for Sustainable Development

This proceeding contains articles on the various ideas of the academic community presented at the International Conference on Frontiers in Desalination, Energy, Environment and Material Sciences for Sustainable Development (FEEMSSD-2023) & Annual Congress of InDA (InDACON-2023) jointly organized by the Madan Mohan Malaviya University of Technology Gorakhpur, KIPM-College of Engineering and Technology Gida Gorakhpur, and Indian Desalination Association, India on 16th-17th March 2023.  FEEMSSD-2023 & InDACON-2023 focuses on addressing issues and concerns related to sustainability in all domains of Energy, Environment, Desalination, and Material Science and attempts to present the research and innovative outputs in a global platform. The conference aims to bring together leading academicians, researchers, technocrats, practitioners, and students to exchange and share their experiences and research outputs in Energy, Environment, Desalination, and Material Science.  Conference Title: International Conference on Frontiers in Desalination, Energy, Environment and Material Sciences for Sustainable Development & Annual Congress of InDAConference Acronyms: FEEMSSD-2023 & InDACON-2023Conference Date: 16th-17th March 2023Conference Location: Madan Mohan Malaviya University of Technology, GorakhpurConference Organizers: Madan Mohan Malaviya University of Technology Gorakhpur, KIPM-College of Engineering and Technology Gida Gorakhpur, and Indian Desalination Association, Indi