Noise invariant frame selection: a simple method to address the background noise problem for text-independent speaker verification

The performance of speaker-related systems usually degrades heavily in practical applications largely due to the background noise. To improve the robustness of such systems in unknown noisy environments, this paper proposes a simple pre-processing method called Noise Invariant Frame Selection (NIFS). Based on several noisy constraints, it selects noise invariant frames from utterances to represent speakers. Experiments conducted on the TIMIT database showed that the NIFS can significantly improve the performance of Vector Quantization (VQ), Gaussian Mixture Model-Universal Background Model (GMM-UBM) and i-vector-based speaker verification systems in different unknown noisy environments with different SNRs, in comparison to their baselines. Meanwhile, the proposed NIFS-based speaker systems has achieves similar performance when we change the constraints (hyper-parameters) or features, which indicates that it is easy to reproduce. Since NIFS is designed as a general algorithm, it could be further applied to other similar tasks

Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

Additional file 1. Supplemental information of ULP-SeNPs concerns their stability in physiological solutions, uptake by BMDMs and effect on NF-κB activation

MicroRNA-29b-3p promotes 5-fluorouracil resistance <em>via</em> suppressing TRAF5-mediated necroptosis in human colorectal cancer

Drug resistance in colorectal cancer is a great challenge in clinic. Elucidating the deep mechanism underlying drug resistance will bring much benefit to diagnosis, therapy and prognosis in patients with colorectal cancer. In this study, miR-29b-3p was shown to be involved in resistance to 5-fluorouracil (5-FU)-induced necroptosis of colorectal cancer. Further, miR-29b-3p was shown to target a regulatory subunit of necroptosis TRAF5. Rescue of TRAF5 could reverse the effect of miR-29b-3p on 5-FU-induced necroptosis, which was consistent with the role ofnecrostatin-1 (a specific necroptosis inhibitor). Then it was demonstrated that miR-29b-3p was positively correlated with chemo-resistance in colorectal cancer while TRAF5 negatively. In conclusion, it is deduced that miR-29b-3p/TRAF5 signaling axis plays critical role in drug resistance in chemotherapy for colorectal cancer patients by regulating necroptosis. The findings in this study provide us a new target for interfere therapy in colorectal cancer

Role of vector resistance and grafting infection in Huanglongbing control models

Citrus huanglongbing (HLB) is one of the most devastating diseases affecting citrus almost worldwide due to the lack of a cure. To better understand the impact of insecticide resistance and grafting infection on the spread of HLB disease, a vector-borne compartmental model is formulated to describe the transmission dynamics of HLB between citrus and Asian citrus psyllid (ACP). The basic reproduction number R0 is computed by using the next generation matrix approach, which is a threshold value of the uniform persistence and disappearance of HLB disease. By applying the sensitivity analysis of R0, we obtain some parameters with the most significant influence on the transmission dynamics of HLB. Moreover, we also obtain that grafting infection has the least influence on the transmission dynamics of HLB. Additionally, a time-dependent control model of HLB to minimize the cost of implementing control efforts and infected trees and ACPs is formulated. By using Pontryagin's Minimum Principle, we obtain the optimal integrated strategy and prove the uniqueness of optimal control solution. The simulation results illustrate that the strategy involving two time-dependent optimal controls is the most effective to suppress the spread of the disease. However, insecticide spraying is more effective measure compared with infected tree removing

Noise invariant frame selection: a simple method to address the background noise problem for text-independent speaker verification

The performance of speaker-related systems usually degrades heavily in practical applications largely due to the background noise. To improve the robustness of such systems in unknown noisy environments, this paper proposes a simple pre-processing method called Noise Invariant Frame Selection (NIFS). Based on several noisy constraints, it selects noise invariant frames from utterances to represent speakers. Experiments conducted on the TIMIT database showed that the NIFS can significantly improve the performance of Vector Quantization (VQ), Gaussian Mixture Model-Universal Background Model (GMM-UBM) and i-vector-based speaker verification systems in different unknown noisy environments with different SNRs, in comparison to their baselines. Meanwhile, the proposed NIFS-based speaker systems has achieves similar performance when we change the constraints (hyper-parameters) or features, which indicates that it is easy to reproduce. Since NIFS is designed as a general algorithm, it could be further applied to other similar tasks

Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) remains a dreadful malignancy bearing poor clinical efficacy, with emerging evidences indicating RNA-binding proteins’ (RBPs’) relevance to the evolution of the disease. Categorized as RBPs, the K-homology domain-containing 1 (KHDC1) family is proved to be closely related to cell survival and death. As a novel KHDC1 member, only one study is currently available in osteoarthritis synovial cells to unveil KHDC1L’s function of promoting proliferation. Nevertheless, to the best of our knowledge, the role of KHDC1L in human tumour is yet to be fully explored. On the basis of The Cancer Genome Atlas (TCGA) database and cell lines comparison with normal counterparts in this study, we first discovered KHDC1L to be overexpressed in HNSCC. According to bioinformatics analysis, apoptosis and P53 pathways were remarkably enriched in the KHDC1L low-expression group in TCGA database. Moreover, in vitro experiments were applied to verify that upregulation of KHDC1L could promote the proliferation and inhibit apoptosis in HNSCC cells CAL27. Transcriptome sequencing ascertained downstream differentially expressed genes to be significantly enriched in PI3K-AKT pathways. Furthermore, as validated by western blot, we found an elevated expression level of pAKT/AKT and Bcl-2, constant expression level of BAX, together with decreased activity of Caspase-3 and PARP-1 in the KHDC1L-upregulated group. In conclusion, our study pioneeringly elaborated that KHDC1L could promote proliferation and inhibit apoptosis in HNSCC cell CAL27 via AKT and Bcl-2 pathways, representing a crucial step for seeking a new diagnostic and therapeutic target in HNSCC

Eight-year tillage in black soil, effects on soil aggregates, and carbon and nitrogen stock

Abstract The effects of different tillage management practices on the soil aggregates, soil carbon stock (STCS), and soil nitrogen stock (STNS) are key issues in agricultural research. We conducted an 8-year field experiment to evaluate the effects of different tillage methods: stubble cleaning and ridging (CK), no-tillage with stubble retention (NT), plow tillage (PT), and width lines (WL) on soil aggregates, STCS, and STNS in the black soil corn continuous cropping area of Northeast China. Different tillage methods predominantly affected the soil aggregates in the 2–0.25 mm and 0.25–0.053 mm size classes. The PT methods increased the proportion of macroaggregates and improved the quality of the soil aggregates. PT methods significantly increased the soil organic carbon content at the 0–30 cm layer by changing the number of soil macroaggregates. The PT practices are better strategies for enhancing soil carbon sinks, and the WL method increased the total amount of N in the soil pool. Our results suggest that the PT and WL methods are the best strategies for improving the quality of soil aggregates and preventing/reducing depletion of soil C and N in a black soil area of Northeast China