3-Phenyl-2-(piperidin-1-yl)-3,5,6,8-tetra­hydro-4H-thio­pyrano[3′,4′:2,3]thieno[5,4-d]pyrimidin-4-one

In the title compound, C20H21N3OS2, the piperidinyl ring has a distorted chair conformation. Weak inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. The crystal packing exhibits short inter­molecular S⋯S distances of 3.590 (2) Å

catena-Poly[[(1,12,15,26-tetra­aza-5,8,19,22-tetra­oxa-3,4:9,10:17,18:23,24-tetra­benzocyclo­octa­cosane-κ4 N 1,N 12,N 15,N 26)nickel(II)]-μ-terephthalato-κ2 O 1:O 4]

In the title compound, [Ni(C8H4O4)(C36H44N4O4)]n, the NiII atom is coordinated in a distorted octa­hedral geometry by the four N atoms of the 1,12,15,26-tetra­aza-5,8,19,22-tetra-oxa-3,4:9,10:17,18:23,24-tetra­benzocyclo­octa­cosane ligand and two O atoms from the terephthalate dianions. The NiII atoms, which lie on inversion centres, are linked via terephthalate ligands to form a chain structure along [101]. The structure is stabilized by three intra­molecular and one inter­molecular N—H⋯O hydrogen bonds

1-[1-(Hydroxy­imino)eth­yl]-N-(2-methoxy­phen­yl)cyclo­propane­carboxamide

The title compound, C13H16N2O3, adopts an E configuration with respect to the C=N bond and an intra­molecular N—H⋯N hydrogen bond results in the formation of a six-membered ring. In the crystal, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into a chain propagating along the b axis. Very weak π–π stacking inter­actions [centroid–centroid distance = 4.18 (2) Å] may further consolidate the packing, forming a two-dimensional supra­molecular network

(Amino­acetato-κ2 O,N)bis­(quinolin-8-olato-κ2 O,N)cobalt(III) methanol solvate

In the crystal structure of the title compound, [Co(C2H4NO2)(C9H6NO)2]·CH3OH, the CoIII atom is chelated by two quinolin-8-olate and one glycinate anions in a distorted octa­hedral coordination geometry. The five-membered chelating glycinate ring assumes an envelope conformation. The complex mol­ecules are assembled by inter­molecular N—H⋯O hydrogen bonding

Ethyl 2-amino-6-benzyl-4,5,6,7-tetra­hydro­thieno[2,3-c]pyridine-3-carboxyl­ate

In the title compound, C17H20N2O2S, the tetra­hydro­pyridine ring adopts an envelope conformation with the N atom at the flap position; the phenyl ring makes a dihedral angle of 81.06 (10)° with the thio­phene ring. The amino group links with the carbonyl O atom via intra­molecular N—H⋯O hydrogen bonding, forming a six-membered ring. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into infinite chains running along the b axis

Difference in Thermotolerance Between Green and Red Color Variants of the Japanese Sea Cucumber, Apostichopus japonicus Selenka: Hsp70 and Heat-Hardening Effect

We studied thermal tolerance limits, heat-hardening, and Hsp70 to elucidate the difference in thermotolerance between two color variants of the sea Cucumber Apostichopus japonicus. Green and Red variants Occupy different habitats and have different aestivation responses to high temperature in summer. In the absence of heat-hardening the variants showed no difference in the temperature at which 50% of the individuals died: Green 31.49 degrees C; Red, 31.39 degrees C. However. Green specimens acquired higher thermotolerance than Red after a prior Sublethal heat exposure. After 72 h of recovery from a heat-hardening treatment (30 degrees C for 2 h) the survival of Green variants was more than 50% and that of Red wits less than 5% when they were treated at 33 degrees C for 2 h. Levels of mRNA and protein for Hsp70 were significantly higher in Green than Red after the heat shock of 30 degrees C, and the stability of hsp70 mRNA of Green was significantly higher than that of Red. Our findings suggest that within the same species, different variants that have similar thermal limits in the absence of heat-hardening can acquire different thermotolerances after a prior sublethal heat shock. The difference in induced thermotolerance between Green and Red is closely related to the expression pattern of Hsp70, which was partly governed by the stability of hsp70 mRNA

N-Phenyl­morpholine-4-carboxamide

In the title compound, C11H14N2O2, the urea-type NC=ON moiety [planar to within 0.0002 (13) Å] is inclined to the phenyl ring by 42.88 (8) Å, and the morpholine ring has a chair conformation. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into infinite chains in [001]

(E)-N′-(Furan-2-ylmethyl­ene)-4-(quinolin-8-yl­oxy)butanohydrazide

In the title mol­ecule, C18H17N3O3, the dihedral angle between the mean planes of the furan ring and the quinoline group is 77.4 (2)°. In the crystal structure, inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into centrosymmetric dimers

Abnormal EEG Complexity and Functional Connectivity of Brain in Patients with Acute Thalamic Ischemic Stroke

Ischemic thalamus stroke has become a serious cardiovascular and cerebral disease in recent years. To date the existing researches mostly concentrated on the power spectral density (PSD) in several frequency bands. In this paper, we investigated the nonlinear features of EEG and brain functional connectivity in patients with acute thalamic ischemic stroke and healthy subjects. Electroencephalography (EEG) in resting condition with eyes closed was recorded for 12 stroke patients and 11 healthy subjects as control group. Lempel-Ziv complexity (LZC), Sample Entropy (SampEn), and brain network using partial directed coherence (PDC) were calculated for feature extraction. Results showed that patients had increased mean LZC and SampEn than the controls, which implied the stroke group has higher EEG complexity. For the brain network, the stroke group displayed a trend of weaker cortical connectivity, which suggests a functional impairment of information transmission in cortical connections in stroke patients. These findings suggest that nonlinear analysis and brain network could provide essential information for better understanding the brain dysfunction in the stroke and assisting monitoring or prognostication of stroke evolution