5,423 research outputs found
Context-aware Sequential Recommendation
Since sequential information plays an important role in modeling user
behaviors, various sequential recommendation methods have been proposed.
Methods based on Markov assumption are widely-used, but independently combine
several most recent components. Recently, Recurrent Neural Networks (RNN) based
methods have been successfully applied in several sequential modeling tasks.
However, for real-world applications, these methods have difficulty in modeling
the contextual information, which has been proved to be very important for
behavior modeling. In this paper, we propose a novel model, named Context-Aware
Recurrent Neural Networks (CA-RNN). Instead of using the constant input matrix
and transition matrix in conventional RNN models, CA-RNN employs adaptive
context-specific input matrices and adaptive context-specific transition
matrices. The adaptive context-specific input matrices capture external
situations where user behaviors happen, such as time, location, weather and so
on. And the adaptive context-specific transition matrices capture how lengths
of time intervals between adjacent behaviors in historical sequences affect the
transition of global sequential features. Experimental results show that the
proposed CA-RNN model yields significant improvements over state-of-the-art
sequential recommendation methods and context-aware recommendation methods on
two public datasets, i.e., the Taobao dataset and the Movielens-1M dataset.Comment: IEEE International Conference on Data Mining (ICDM) 2016, to apea
Deterministic versus probabilistic quantum information masking
We investigate quantum information masking for arbitrary dimensional quantum
states. We show that mutually orthogonal quantum states can always be served
for deterministic masking of quantum information. We further construct a
probabilistic masking machine for linearly independent states. It is shown that
a set of d dimensional states, , , can be probabilistically masked by a general
unitary-reduction operation if they are linearly independent. The maximal
successful probability of probabilistic masking is analyzed and derived for the
case of two initial states.Comment: 5 pages, 1 figure
A solution processed flexible nanocomposite electrode with efficient light extraction for organic light emitting diodes.
Highly efficient organic light emitting diodes (OLEDs) based on multiple layers of vapor evaporated small molecules, indium tin oxide transparent electrode, and glass substrate have been extensively investigated and are being commercialized. The light extraction from the exciton radiative decay is limited to less than 30% due to plasmonic quenching on the metallic cathode and the waveguide in the multi-layer sandwich structure. Here we report a flexible nanocomposite electrode comprising single-walled carbon nanotubes and silver nanowires stacked and embedded in the surface of a polymer substrate. Nanoparticles of barium strontium titanate are dispersed within the substrate to enhance light extraction efficiency. Green polymer OLED (PLEDs) fabricated on the nanocomposite electrode exhibit a maximum current efficiency of 118 cd/A at 10,000 cd/m(2) with the calculated external quantum efficiency being 38.9%. The efficiencies of white PLEDs are 46.7 cd/A and 30.5%, respectively. The devices can be bent to 3 mm radius repeatedly without significant loss of electroluminescent performance. The nanocomposite electrode could pave the way to high-efficiency flexible OLEDs with simplified device structure and low fabrication cost
3-(4-Chlorophenyl)-1-(4-nitrophenyl)benzo[f]quinoline
In the title compound, C25H15ClN2O2, the pyridine ring is inclined at angles of 6.89 (7), 4.24 (9) and 66.98 (4)° with respect to the naphthalene, chlorophenyl and nitrophenyl rings, respectively. The two substituent aromatic rings make a dihedral angle of 71.1 (1)° with one another. C—H⋯π and π–π stacking are present in the crystal structure; the π–π stacking [centroid–centroid distance between the pyridyl rings of adjacent molecules= 3.7838 (11) Å] links the molecules into dimers, while the C—H⋯Cg type π–ring interactons link the molecules into a chain structure along c
The Role of Antiviral Therapy for HBV-Related Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer worldwide; despite the curative treatment for HCC, the rate of tumor recurrence after hepatectomy remains high. Tumor recurrence can occur early (<2 years) or late (>2 years) as metastases or de novo tumors. Several tumor factors were associated with HCC recurrence; high hepatitis B virus (HBV) load is the major risk factor for late recurrence of HCC after resection. Preoperative antiviral therapy improves liver function, and postoperative reduce HCC recurrence. In this paper, we focus on antiviral treatment to improve the liver function, prevent recurrence, and lengthen the overall survival for HBV-related HCC
Albumin fibrillization induces apoptosis via integrin/FAK/Akt pathway
[[abstract]]Background: Numerous proteins can be converted to amyloid-like fibrils to increase cytotoxicity and induce apoptosis, but the methods generally require a high concentration of protein, vigorous shaking, or fibril seed. As well, the detailed mechanism of the cytotoxic effects is not well characterized. In this study, we have developed a novel process to convert native proteins into the fibrillar form. We used globular bovine serum albumin (BSA) as a model protein to verify the properties of the fibrillar protein, investigated its cellular effects and studied the signaling cascade induced by the fibrillar protein. Results: We induced BSA, a non-cytotoxic globular protein, to become fibril by a novel process involving Superdex-200 column chromatography in the presence of anionic or zwittergenic detergent(s). The column pore size was more important than column matrix composite in fibril formation. The fibrillar BSA induced apoptosis in BHK-21 cell as well as breast cancer cell line T47D. Pre-treating cells with anti-integrin antibodies blocked the apoptotic effect. Fibrillar BSA, but not globular BSA, bound to integrin, dephosphorylated focal adhesion kinase (FAK), Akt and glycogen synthase kinase-3β (GSK-3β). Conclusion: We report on a novel process for converting globular proteins into fibrillar form to cause apoptosis by modulating the integrin/FAK/Akt/GSK-3β/caspase-3 signaling pathway. Our findings may be useful for understanding the pathogenesis of amyloid-like fibrils and applicable for the development of better therapeutic agents that target the underlying mechanism(s) of the etiologic agents. ? 2009 Huang et al; licensee BioMed Central Ltd
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