On improving the accuracy of the M2 barotropic tides embedded in a high-resolution global ocean circulation model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116867/1/ocemod_ASEnKF_tides_ngodocketal_2016.pd

Indirect evidence for substantial damping of low-mode internal tides in the open ocean

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115484/1/Ansong_et_al-2015-Journal_of_Geophysical_Research-_Oceans.pd

Optimizing internal wave drag in a forward barotropic model with semidiurnal tides

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109739/1/ocemod_buijsmanetal_2015.pd

Assessment of shelf sea tides and tidal mixing fronts in a global ocean model

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148272/1/ocemod_2019_shelftidesandfronts_timkoetal.pdfDescription of ocemod_2019_shelftidesandfronts_timkoetal.pdf : Main articl

Semidiurnal internal tide incoherence in the equatorial Pacific

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138087/1/jgr_2017_buijsmanetal_equatorialincoherence.pd

The global mesoscale eddy available potential energy field in models and observations

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140400/1/jgr_2017_lueckeetal_lowfrequencyEAPE.pdfDescription of jgr_2017_lueckeetal_lowfrequencyEAPE.pdf : Mian articl

Spectral decomposition of internal gravity wave sea surface height in global models

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140401/1/jgr_2017_savageetal_IGWsshspectra.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/140401/2/jgr_2017_savageetal_IGWsshspectra_SUPPLEMENTARYMATERIAL.pdfDescription of jgr_2017_savageetal_IGWsshspectra.pdf : Main articleDescription of jgr_2017_savageetal_IGWsshspectra_SUPPLEMENTARYMATERIAL.pdf : Supplementary materia

Pathogenic Germline Variants in 10,389 Adult Cancers

We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. The 659 predisposition variants and 18 additional large deletions in tumor suppressors, including ATM, BRCA1, and NF1, showed low gene expression and frequent (43%) loss of heterozygosity or biallelic two-hit events. We also discovered 33 such variants in oncogenes, including missenses in MET, RET, and PTPN11 associated with high gene expression. We nominated 47 additional predisposition variants from prioritized VUSs supported by multiple evidences involving case-control frequency, loss of heterozygosity, expression effect, and co-localization with mutations and modified residues. Our integrative approach links rare predisposition variants to functional consequences, informing future guidelines of variant classification and germline genetic testing in cancer. A pan-cancer analysis identifies hundreds of predisposing germline variants