SPECTROPHOTOMETRIC DETERMINATION OF BALOFLOXACIN BY ION-PAIR COMPLEXATION REACTION IN THE BULK AND TABLET DOSAGE FORMS

A rapid, sensitive and accurate spectrophotometric method for the determination of balofloxacin, an antibacterial fluoroquinolone has been developed and validated for its analysis in tablet formulation. In this method, balofloxacin is allowed to react with the bromocresol green (BCG) dye in aqueous acidic buffer. The yellow colored complex species was formed that was extracted into organic solvent, dichloromethane. The formed complexes are quantified spectrophotometrically at the absorption maxima at 412 nm. Linearity was observed over the concentration range of 4-30 µg /ml, with the calibration curve having a good coefficient of correlation of 0.9940. The validated method was accurate as found from recovery of 96.65%-101.26% when applied for marketed tablet formulation of balofloxacin, and thus can be used in quality control and its routine analysis

Neuromatch Academy: a 3-week, online summer school in computational neuroscience

Neuromatch Academy (https://academy.neuromatch.io; (van Viegen et al., 2021)) was designed as an online summer school to cover the basics of computational neuroscience in three weeks. The materials cover dominant and emerging computational neuroscience tools, how they complement one another, and specifically focus on how they can help us to better understand how the brain functions. An original component of the materials is its focus on modeling choices, i.e. how do we choose the right approach, how do we build models, and how can we evaluate models to determine if they provide real (meaningful) insight. This meta-modeling component of the instructional materials asks what questions can be answered by different techniques, and how to apply them meaningfully to get insight about brain function

Impact of BMI on patients oral health and patients co-operation undergoing fixed orthodontic mechanotherapy

Over the last decades, overweight and obesity has become a problem in the economically developed world. The increasing number of overweight adults is alarming. During orthodontic therapy with fixed appliances, the development of white spot lesions (WSLs) is a relatively common negative side-effect. Concerning oral health, some evidence exists that there might be an association between overweight and an increased caries risk in children, but this relationship is not unambiguous. Therefore, the aim of this retrospective, explorative study was to compare normal, overweight, and obese orthodontic patients undergoing fixed appliance therapy. Therefore, it was concluded that an increased BMI appears to be a risk factor for less cooperation, a longer treatment duration, and more oral health-related problems during MB treatment, indicating that these patients require special attention during orthodontic therapy

Usefulness of smartphone based communication in improving oral hygiene in patients undergoing orthodontic treatment: Systematic review and meta-analysis

The Digital revolution has led to a paradigm shift in industries including health care. Difficulty to clean between the teeth, lack of motivation and dietary factors are significantly associated with dental caries in patients undergoing orthodontic treatment. This study assessed the effectiveness of mobile phone applications in improving oral hygiene care and oral health outcomes in patients undergoing fixed orthodontic treatment. Within the available evidence, a recommendation can be made for the use of mobile applications in the orthodontic process care

Rituximab May Confer Protective Effect on Retinal Nerve Fiber Layer in Multiple Sclerosis

Painful visual loss due to optic neuritis is a common presentation for an acute flare of multiple sclerosis (MS). Optical coherence tomography (OCT) has emerged as a tool to evaluate thinning of the retinal nerve fiber layer (RNFL) in patients with demyelinating conditions and may be useful in assessing subclinical progression of disease. Disease modifying therapies such as natalizumab have been implicated in stabilizing RNFL loss in MS (Talmage et al. 2017), but no such study has been done with Rituximab, which is a monoclonal Anti-CD20 antibody shown to be effective in treating MS (Alcala et al., 2018)