Prospective, observational, multicenter study on minimally invasive gastrectomy for gastric cancer: robotic, laparoscopic and open surgery compared on operative and follow-up outcomes - IMIGASTRIC II study protocol: IMIGASTRIC II

Background:Several meta-analyses have tried to defi ne the role of minimally invasive approaches. However, further evidence to get a wider spread of these methods is necessary. Current studies describe minimally invasive surgery as a possible alternative to open surgery but deserving further clarifi cation. However, despite the increasing interest, the difficulty of planning prospective studies of adequate size accounts for the low level of evidence, which is mostly based on retrospective experiences.A multi-institutional prospective study allows the collection of an impressive amount of data to investigate various aspects of minimally invasive procedures with the opportunity of developing several subgroup analyses.A prospective data collection with high methodological quality on minimally invasive and open gastrectomies can clarify the role of diff erent procedures with the aim to develop specifi c guidelines.Methods and analysis:a multi-institutional prospective database will be established including information on surgical, clinical and oncological features of patients treated for gastric cancer with robotic, laparoscopic or open approaches and subsequent follow-up.The study has been shared by the members of the International study group on Minimally Invasive surgery for GASTRIc Cancer (IMIGASTRIC)The database is designed to be an international electronic submission system and a HIPPA protected real time data repository from high volume gastric cancer centers.Ethics:This study is conducted in compliance with ethical principles originating from the Helsinki Declaration, within the guidelines of Good Clinical Practice and relevantlaws/regulations.Trial registration number:NCT0275108

TIPE2 acts as a biomarker for GIST risk category and suppresses the viability and invasiveness of GIST cells

Abstract Evaluating the risk category of gastrointestinal stromal tumors (GISTs) is crucial for predicting prognosis and choosing treatment strategies, and tumor metastasis usually represent poor prognosis. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel described tumor suppressor. In the present study, TIPE2 expression was detected using a total of 96 human GIST specimens by immunohistochemistry. The effect of TIPE2 on proliferation and invasiveness of GIST cells and its related mechanisms were explored in vitro. It was found that TIPE2 expression was gradually decreased in accordance with GIST risk grades and negatively associated with tumor size, mitotic count and risk category. Moreover, TIPE2 was identified as a biomarker for evaluating the risk grade of GIST. TIPE2 markedly suppressed the viability, colony formation, migration and invasion of GIST cells. Furthermore, TIPE2 induced apoptosis and suppressed MMP-9 expression of GIST cells by targeting Rac1. In conclusion, these results indicate that TIPE2 plays a pivotal role in the progression of GIST. TIPE2 serves as a promising biomarker for evaluating GIST risk grade and a potential target for treatment of GIST

Polyethylenimine as a dual functional additive for electron transporting layer in efficient solution processed planar heterojunction perovskite solar cells

We report a doping method to enhance the performance of solution processed planar heterojunction perovskite solar cells. By doping a small percentage (3 wt%) of polyethylenimine (PEI) as additive into the PCBM electron transport layer of an inverted perovskite solar cell, which led to significant enhancements of power conversion efficiency from (5.9 +/- 0.2) % to (10.4 +/- 0.2) %. The AFM images show that the PEI doped PCBM layer can help to form a high quality, homogeneous and compact electron transporting layer on the rough CH3NH3PbI3 layer, which results in enhanced hole blocking ability and reduced leakage current at the interfaces between the CH3NH3PbI3, PCBM films and the top Al electrode. Organic field-effect transistors (OFETs) measurements reveal that the addition of 1-3 wt% PEI into PCBM layer can improve device performance without any negative effect on the electron transport property of PCBM. Steady-state PL analysis shows that the electron-rich PEI may also act as an effective interfacial modifier to passivate the trap states at the perovskite surface or crystal boundaries and to avoid the undesired charge recombination often observed in perovskite solar cells. PEI will also improve performance as a cathode interfacial modifier because the PCE of the device with PEI deposited between PCBM and Al is superior to the device without PEI. This work demonstrated that amine-containing polymer materials can be used as an efficient dual functional additive in perovskite solar cells. This study provides an efficient way of developing highly efficient CH3NH3PbI3-based perovskite solar cells

Adjustment and Matching of Energy Band of TiO₂‑Based Photocatalysts by Metal Ions (Pd, Cu, Mn) for Photoreduction of CO₂ into CH₄

A series of the metal ions (Pd, Cu, and Mn) modified TiO₂ photocatalysts are synthesized via simple sol–gel method. Characterized by X-ray diffraction, Raman, UV–vis absorption spectra, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, time-resolved photoluminescence (PL) decay curves, and PL, it was revealed these introduced metal ions existed as O–Me–O species (Me: Pd, Cu, and Mn) on the surface of TiO₂. The corresponding theory calculation is used to investigate the electronic density of states and band structure of the metal ions (Pd, Cu, and Mn) modified TiO₂. The modified TiO₂ photocatalysts exhibit an improved photocatalytic performance on reduction of CO₂ and H₂O into methane (CH₄), attributed to the contribution of surface species by enhancing the visible absorption efficiently, separating charge carriers, and matching of the redox potential on the photoreduction of CO₂ into CH₄. This article could provide a wider understanding about the adjustment and matching of the energy level for the synthesis and design of functional materials with excellent photocatalytic performance

Additional file 1 of Effect of preoperative immunonutrition on postoperative short-term clinical outcomes in patients with gastric cancer cachexia: a prospective randomized controlled trial

Supplementary Material

Multimodal prehabilitation to improve the clinical outcomes of frail elderly patients with gastric cancer: a study protocol for a multicentre randomised controlled trial (GISSG+2201)

Introduction Gastric cancer (GC) diagnosed in the elderly population has become a serious public health problem worldwide. Given the combined effects of frailty and the consequences of cancer treatment, older individuals with GC are more likely than young patients to suffer from postoperative complications and poor clinical outcomes. Nutrition, functional capacity and psychological state-based multimodal prehabilitation, which is dominated by Enhanced Recovery After Surgery (ERAS) pathway management, has been shown to reduce postoperative complications, promote functional recovery and decrease hospitalisation time in certain malignancies. However, no previous studies have investigated the clinical application of multimodal prehabilitation in frail older patients with GC.Methods and analysis The study is a prospective, multicentre randomised controlled trial in which a total of 368 participants who meet the inclusion criteria will be randomised into either a prehabilitation group or an ERAS group. The prehabilitation group will receive multimodal prehabilitation combined with ERAS at least 2 weeks before the gastrectomy is performed, including physical and respiratory training, nutritional support, and therapy and psychosocial treatment. The ERAS group patients will be treated according to the ERAS pathway. All interventions will be supervised by family members. The primary outcome measures are the incidence and severity of postoperative complications. Secondary outcomes include survival, functional capacity and other short-term postoperative outcomes. Overall, the multimodal prehabilitation protocol may improve functional capacity, reduce the surgical stress response and concomitant systemic inflammation, and potentially modulate the tumour microenvironment to improve short-term and long-term clinical outcomes and patients’ quality of life.Ethics and dissemination All procedures and participating centres of this study were approved by their respective ethics committees (QYFYKYLL 916111920). The final study results will be published separately in peer-reviewed journals.Trial registration number NCT05352802