3,562 research outputs found

    Working Together for Children and Families: A Community Guide to Making the Most of Out-of-School Time

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    Outlines the MOST Initiative's approach to building a community-based, collaborative out-of-school time system in Boston, Chicago, and Seattle. Illustrates how each city interpreted the MOST process and provides a sampling of their activities

    Medical Professionalization: Pitfalls and Promise in the Historiography

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    Optimization of Optical and Mechanical Properties of Real Architecture for 3-Dimensional Tissue Equivalents: Towards Treatment of Limbal Epithelial Stem Cell Deficiency

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    Limbal epithelial stem cell (LESC) deficiency can cause blindness. Transplantation of cultured human limbal epithelial cells (hLE) on human amniotic membrane (HAM) can restore vision but clinical graft manufacture can be unreliable. We have developed a reliable and robust tissue equivalent (TE) alternative to HAM, Real Architecture for 3D Tissue (RAFT). Here, we aimed to optimize the optical and mechanical properties of RAFT TE for treatment of LESC deficiency in clinical application. The RAFT TE protocol is tunable; varying collagen concentration and volume produces differing RAFT TEs. These were compared with HAM samples taken from locations proximal and distal to the placental disc. Outcomes assessed were transparency, thickness, light transmission, tensile strength, ease of handling, degradation rates and suitability as substrate for hLE culture. Proximal HAM samples were thicker and stronger with poorer optical properties than distal HAM samples. RAFT TEs produced using higher amounts of collagen were thicker and stronger with poorer optical properties than those produced using lower amounts of collagen. The ‘optimal’ RAFT TE was thin, transparent but still handleable and was produced using 0.6 ml of 3 mg/ml collagen. Degradation rates of the ‘optimal’ RAFT TE and HAM were similar. hLE achieved confluency on ‘optimal’ RAFT TEs at comparable rates to HAM and cells expressed high levels of putative stem cell marker p63α. These findings support the use of RAFT TE for hLE transplantation towards treatment of LESC deficiency

    Are income-related differences in active travel associated with physical environmental characteristics? A multi-level ecological approach

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    Background: Rates of active travel vary by socio-economic position, with higher rates generally observed among less affluent populations. Aspects of both social and built environments have been shown to affect active travel, but little research has explored the influence of physical environmental characteristics, and less has examined whether physical environment affects socio-economic inequality in active travel. This study explored income-related differences in active travel in relation to multiple physical environmental characteristics including air pollution, climate and levels of green space, in urban areas across England. We hypothesised that any gradient in the relationship between income and active travel would be least pronounced in the least physically environmentally-deprived areas where higher income populations may be more likely to choose active transport as a means of travel.<p></p> Methods: Adults aged 16+ living in urban areas (n = 20,146) were selected from the 2002 and 2003 waves of the UK National Travel Survey. The mode of all short non-recreational trips undertaken by the sample was identified (n = 205,673). Three-level binary logistic regression models were used to explore how associations between the trip being active (by bike/walking) and three income groups, varied by level of multiple physical environmental deprivation.<p></p> Results: Likelihood of making an active trip among the lowest income group appeared unaffected by physical environmental deprivation; 15.4% of their non-recreational trips were active in both the least and most environmentally-deprived areas. The income-related gradient in making active trips remained steep in the least environmentally-deprived areas because those in the highest income groups were markedly less likely to choose active travel when physical environment was ‘good’, compared to those on the lowest incomes (OR = 0.44, 95% CI = 0.22 to 0.89).<p></p> Conclusions: The socio-economic gradient in active travel seems independent of physical environmental characteristics. Whilst more affluent populations enjoy advantages on some health outcomes, they will still benefit from increasing their levels of physical activity through active travel. Benefits of active travel to the whole community would include reduced vehicle emissions, reduced carbon consumption, the preservation or enhancement of infrastructure and the presentation of a ‘normalised’ behaviour

    It's About Time: A Look at Out-of-School Time for Urban Teens

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    Investigates after-school opportunities and experiences for high school age youth in 21 U.S. cities, with a focus on Baltimore, Chicago, Denver, Kansas City, and Fort Worth. Includes a look at the steps necessary for building a citywide collaboration

    Vocational Education & Training (VET) and professional education in health care and nursing in Ireland

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    This Chapter forms part of a publication by ITB, University of Bremem produced as part of the CREDICARE project. This Chapter aims to give a comprehensive overview of Vocational Education & training and professional education in relation to Nurse Training Programmes currently (2011-12) operating within the Irish national context, thus contributing to the overall CREDICARE European macro context. Additionally this chapter porports to explore the entry requirements from both formal (university) and informal (access courses) perspectives as illustrated in the National Framework Qualifications (NFQ) system and to draw overall comparison with the European Qualification Framework (EQF). Furthermore this report examines the roles and responsibilities of the various stakeholders involved in relation to pre and post registration2 nurse training programmes available nationwide as well as outlining the role of and discussing An Bord Altranais (the regulatory board), The Nursing Careers Centre, entry requirements, programmes available, employment structure, and other relevant issues relating to the nursing education system in Irelan

    Changing Expectations, Same Perspective: Pre-service Teachers’ Judgments of Professional Efficacy

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    This two-part study tracks and measures the professional self-efficacy judgements of two cohorts of pre-service teachers (PST). In Part One, the GTCE’s Code of Conduct and Practice (GTCE, 2009) was used to help form an instrument which tracked changes in the professional self-efficacy judgements of 211 PST through a one-year graduate program. Judgements were sought from PST both about themselves, and importantly, also about practicing teachers in the profession. In Part Two, statements making up the new DfE Teaching Standards (DfE, 2011) were similarly used to form an instrument and used with a subsequent cohort of 416 PST. Outcomes showed that PST’s judgement of professional self-efficacy were extremely high on both occasions, and in nearly all cases, significantly more positive than their ratings for current serving teachers. Tracked through their one-year program, the self-judgements barely changed, although views of the practicing teaching increased markedly, although never quite reaching the levels of self-judgements. The detail and significance of these findings is analysed and discussed

    Localisation of gamma-ray interaction points in thick monolithic CeBr3 and LaBr3:Ce scintillators

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    Localisation of gamma-ray interaction points in monolithic scintillator crystals can simplify the design and improve the performance of a future Compton telescope for gamma-ray astronomy. In this paper we compare the position resolution of three monolithic scintillators: a 28x28x20 mm3 (length x breadth x thickness) LaBr3:Ce crystal, a 25x25x20 mm3 CeBr3 crystal and a 25x25x10 mm3 CeBr3 crystal. Each crystal was encapsulated and coupled to an array of 4x4 silicon photomultipliers through an optical window. The measurements were conducted using 81 keV and 356 keV gamma-rays from a collimated 133Ba source. The 3D position reconstruction of interaction points was performed using artificial neural networks trained with experimental data. Although the position resolution was significantly better for the thinner crystal, the 20 mm thick CeBr3 crystal showed an acceptable resolution of about 5.4 mm FWHM for the x and y coordinates, and 7.8 mm FWHM for the z-coordinate (crystal depth) at 356 keV. These values were obtained from the full position scans of the crystal sides. The position resolution of the LaBr3:Ce crystal was found to be considerably worse, presumably due to the highly diffusive optical in- terface between the crystal and the optical window of the enclosure. The energy resolution (FWHM) measured for 662 keV gamma-rays was 4.0% for LaBr3:Ce and 5.5% for CeBr3. The same crystals equipped with a PMT (Hamamatsu R6322-100) gave an energy resolution of 3.0% and 4.7%, respectively
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