Impact of meningitis on intelligence and development: A systematic review and meta-analysis

BACKGROUND: We undertook a systematic review and meta-analysis to address the question "what is the impact of meningitis on IQ and development." METHODS: Search: conducted using standardized search terms across Medline, PsychInfo and EMBASE to 06/2014. Eligibility: human studies of any infectious aetiology of meningitis reporting IQ or infant developmental age or stage outcomes. Quality: Centre for Evidence Based Medicine, Oxford, quality tools. Analysis: random effects meta-analysis by organism. RESULTS: 39 studies were included in the review, 34 providing data on IQ (2015 subjects) and 12 on developmental delay (382 subjects). Across all bacterial organisms, meningitis survivors had a mean IQ 5.50 (95% CI: -7.19, -3.80; I2 = 47%, p = 0.02) points lower than controls. IQ was significantly lower than controls for Neisseria meningitides (NM: 5 points) and Haemophilus influenzae b (Hib: 6 points) but not in viral meningitis, with only single studies included for Streptococcus pneumoniae (SP) and group B streptococcus (GBS). The pooled relative risk (RR) for low IQ (IQ<70) in survivors of bacterial meningitis compared with controls was 4.99 (95% CI: 3.17, 7.86) with no significant heterogeneity (I2 = 49%, p = 0.07). Developmental delay of approximately 0.5SD was reported in studies of bacterial meningitis but no delay in the only study of viral meningitis. CONCLUSIONS: We found moderate evidence that surviving bacterial meningitis has a deleterious impact on IQ and development but no evidence that viral meningitis had meaningful cognitive impacts. Survivors of bacterial meningitis should be routinely offered screening for cognitive deficits and developmental delay in addition to hearing loss

A generalized theory of semiflexible polymers

DNA bending on length scales shorter than a persistence length plays an integral role in the translation of genetic information from DNA to cellular function. Quantitative experimental studies of these biological systems have led to a renewed interest in the polymer mechanics relevant for describing the conformational free energy of DNA bending induced by protein-DNA complexes. Recent experimental results from DNA cyclization studies have cast doubt on the applicability of the canonical semiflexible polymer theory, the wormlike chain (WLC) model, to DNA bending on biological length scales. This paper develops a theory of the chain statistics of a class of generalized semiflexible polymer models. Our focus is on the theoretical development of these models and the calculation of experimental observables. To illustrate our methods, we focus on a specific toy model of DNA bending. We show that the WLC model generically describes the long-length-scale chain statistics of semiflexible polymers, as predicted by the Renormalization Group. In particular, we show that either the WLC or our new model adequate describes force-extension, solution scattering, and long-contour-length cyclization experiments, regardless of the details of DNA bend elasticity. In contrast, experiments sensitive to short-length-scale chain behavior can in principle reveal dramatic departures from the linear elastic behavior assumed in the WLC model. We demonstrate this explicitly by showing that our toy model can reproduce the anomalously large short-contour-length cyclization J factors observed by Cloutier and Widom. Finally, we discuss the applicability of these models to DNA chain statistics in the context of future experiments

Supersymmetric Jaynes-Cummings model and its exact solutions

The super-algebraic structure of a generalized version of the Jaynes-Cummings model is investigated. We find that a Z2 graded extension of the so(2,1) Lie algebra is the underlying symmetry of this model. It is isomorphic to the four-dimensional super-algebra u(1/1) with two odd and two even elements. Differential matrix operators are taken as realization of the elements of the superalgebra to which the model Hamiltonian belongs. Several examples with various choices of superpotentials are presented. The energy spectrum and corresponding wavefunctions are obtained analytically.Comment: 12 pages, no figure

Excitation Spectrum of the Holstein Model

In this paper the polaron problem for the Holstein model is studied in the weak coupling limit. We use second order perturbation theory to construct renormalized electron and phonons. Eigenstates of the Hamiltonian are labelled and the excitation spectrum is constructed.Comment: 4 pages, revtex, 1 figures, more stuff at http://www.mpipks-dresden.mpg.de/~robin/robin.htm

Chemical Abundance Gradients in the Star-Forming Ring Galaxies

Ring waves of star formation, propagating outwardly in the galactic disks, leave chemical abundance gradients in their wakes. We show that the relative [Fe/O] abundance gradients in ring galaxies can be used as a tool for determining the role of the SNIa explosions in their chemical enrichment. We consider two mechanisms which can create outwardly propagating star forming rings in a purely gaseous disk -- a self-induced wave and a density wave, and demonstrate that the radial distribution of the relative [Fe/O] abundance gradients does not depend on the particular mechanism of the wave formation or on the parameters of the star-forming process. We show that the [Fe/O] profile is determined by the velocity of the wave, initial mass function, and the initial chemical composition of the star-forming gas. If the role of SNIa explosions is negligible in the chemical enrichment, the ratio [Fe/O] remains constant throughout the galactic disk with a steep gradient at the wave front. If SNIa stars are important in the production of cosmic iron, the [Fe/O] ratio has gradient in the wake of the star-forming wave with the value depending on the frequency of SNIa explosions.Comment: Uses aas2pp4.sty and epsfig.sty, 7 pages including one figure To appear in Astrophysical Journa

Coherent strong-field control of multiple states by a single chirped femtosecond laser pulse

We present a joint experimental and theoretical study on strong-field photo-ionization of sodium atoms using chirped femtosecond laser pulses. By tuning the chirp parameter, selectivity among the population in the highly excited states 5p, 6p, 7p and 5f, 6f is achieved. Different excitation pathways enabling control are identified by simultaneous ionization and measurement of photoelectron angular distributions employing the velocity map imaging technique. Free electron wave packets at an energy of around 1 eV are observed. These photoelectrons originate from two channels. The predominant 2+1+1 Resonance Enhanced Multi-Photon Ionization (REMPI) proceeds via the strongly driven two-photon transition $4s\leftarrow\leftarrow3s$, and subsequent ionization from the states 5p, 6p and 7p whereas the second pathway involves 3+1 REMPI via the states 5f and 6f. In addition, electron wave packets from two-photon ionization of the non-resonant transiently populated state 3p are observed close to the ionization threshold. A mainly qualitative five-state model for the predominant excitation channel is studied theoretically to provide insights into the physical mechanisms at play. Our analysis shows that by tuning the chirp parameter the dynamics is effectively controlled by dynamic Stark-shifts and level crossings. In particular, we show that under the experimental conditions the passage through an uncommon three-state "bow-tie" level crossing allows the preparation of coherent superposition states

Electromagnetic response of a static vortex line in a type-II superconductor : a microscopic study

The electromagnetic response of a pinned Abrikosov fluxoid is examined in the framework of the Bogoliubov-de Gennes formalism. The matrix elements and the selection rules for both the single photon (emission - absorption) and two photon (Raman scattering) processes are obtained. The results reveal striking asymmetries: light absorption by quasiparticle pair creation or single quasiparticle scattering can occur only if the handedness of the incident radiation is opposite to that of the vortex core states. We show how these effects will lead to nonreciprocal circular birefringence, and also predict structure in the frequency dependence of conductivity and in the differential cross section of the Raman scattering.Comment: 14 pages (RevTex

States interpolating between number and coherent states and their interaction with atomic systems

Using the eigenvalue definition of binomial states we construct new intermediate number-coherent states which reduce to number and coherent states in two different limits. We reveal the connection of these intermediate states with photon-added coherent states and investigate their non-classical properties and quasi-probability distributions in detail. It is of interest to note that these new states, which interpolate between coherent states and number states, neither of which exhibit squeezing, are nevertheless squeezed states. A scheme to produce these states is proposed. We also study the interaction of these states with atomic systems in the framework of the two-photon Jaynes-Cummings model, and describe the response of the atomic system as it varies between the pure Rabi oscillation and the collapse-revival mode and investigate field observables such as photon number distribution, entropy and the Q-function.Comment: 26 pages, 29 EPS figures, Latex, Accepted for publication in J.Phys.

Entanglement in squeezed two-level atom

In the previous paper, we adopted the method using quantum mutual entropy to measure the degree of entanglement in the time development of the Jaynes-Cummings model. In this paper, we formulate the entanglement in the time development of the Jaynes-Cummings model with squeezed states, and then show that the entanglement can be controlled by means of squeezing.Comment: 6 pages, 5 figures, to be published in J.Phys.

The most rapidly rotating He-strong emission line star: HR7355

Using archival spectroscopic and photometric data, we searched for massive stars with Balmer-emission consistent with magnetically confined circumstellar material. HR 7355 is a formerly unknown He-strong star showing Balmer emission. At V=6.02 mag, it is one of the brightest objects simultaneously showing anomalous helium absorption and hydrogen emission. Among similar objects, only sigma Ori E has so far been subjected to any systematic analysis of the circumstellar material responsible for the emission. We argue that the double-wave photometric period of 0.52d corresponds to the rotation period. In tandem with the high projected equatorial velocity, v sin i=320 km/s, this short period suggests that HR 7355 is the most rapidly rotating He-strong star known to date; a class that was hitherto expected to host stars with slow to moderate rotation only.Comment: 4 pages with 2 figures. Accepted for publication as Research Note by Astronomy and Astrophysic