Finding My Better Self and the Strength to Dream: The Impact of the Honors Experience

As part of the National Collegiate Honors Council’s (2022) collection of essays about the value of honors to its graduates (1967–2019), the author reflects on the personal and professional impacts of the honors experience. H onor. It flows throughout the thread of life and shapes a path at every stage. It serves as an inner compass that navigates through growth and identity to find the destination of a better self. My experience as an honors student represents an important part of this journey and established a foundation of intrinsic values that continue to guide me through my professional and personal landscape. Looking inward today, I recognize these values in the mosaic of my belief system and how they became a driving force in my ongoing evolution as an individual. By honoring the values of critical thinking, continuous improvement, self-trust, and maintaining an active voice, my path remains anchored in wonder and discovery as I pursue my continued development

Do Femtonewton Forces Affect Genetic Function? A Review

Protein-Mediated DNA looping is intricately related to gene expression. Therefore any mechanical constraint that disrupts loop formation can play a significant role in gene regulation. Polymer physics models predict that less than a piconewton of force may be sufficient to prevent the formation of DNA loops. Thus, it appears that tension can act as a molecular switch that controls the much larger forces associated with the processive motion of RNA polymerase. Since RNAP can exert forces over 20 pN before it stalls, a ‘substrate tension switch’ could offer a force advantage of two orders of magnitude. Evidence for such a mechanism is seen in recent in vitro micromanipulation experiments. In this article we provide new perspective on existing theory and experimental data on DNA looping in vitro and in vivo . We elaborate on the connection between tension and a variety of other intracellular mechanical constraints including sequence specific curvature and supercoiling. In the process, we emphasize that the richness and versatility of DNA mechanics opens up a whole new paradigm of gene regulation to explore.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41816/1/10867_2005_Article_9002.pd