PENGARUH KOMBINASI CYCLOPHOSPHAMIDE - TRANSFER FACTOR TERHADAP SKOR SEL T CD4+ PADA ADENOCARSINOMA MAMMAE MENCIT C3H

Background : Transfer factor are extracts from Colostrum, which is considered as an immunostimulant oligoribonukleotida for alternative therapies. Breast cancer patients will experience a decline in the immune system. CD4+ T cells is one of the cellular immune response to cancer. Is Tansfer factor may increase the number of CD4+ T cells. Objective : To analyze the effect of cyclophosphamid-transfer factor to the number of CD4+ T cells in C3H mice mammary Adenocarcinoma. Methods : The research laboratory experimental design with "Randomized posttest only control group." Using pure C3H female 20 mice amounted. Samples were divided into 4 groups : K as a control, P1 given cyclphosphamide, P2 and P3 were given transfer factor were given a combination of cyclophosphamidetransfer factor. As the dependent variable is the number of CD4+ T cells. Analysis of differences between the four groups using ANOVA with 95% confidence level. Results : The difference in the number of CD4+ T cells obtained value of p = <0.001 between the control group (K) to the treatment group (P1, P2, P3) and between treatment groups are given a combination of Cyclophosphamide-transfer factor to the treatment group who were given Cyclophosphamide alone or transfer factor alone. There was no significant difference in the number of CD4+ T cells in treatment groups that were given Cyclophosphamide alone compared with the treatment group who were given transfer factor only. Conclusion : There is increased number of CD4+ T cells significantly in C3H mice mammary adenocarcinoma who were given cyclophosphamide-transfer factor. Keywords: Transfer Factor, cyclophosphamide, CD4+ T cells, mammary adenocarcinom

PROSIDING INTERNATIONAL SEMINAR on ISLAMIC STUDIES AND EDUCATION(ISoISE)

Prosiding ini berisi kumpulan artikel dari narasumber dan peserta INTERNATIONAL SEMINAR on ISLAMIC STUDIES AND EDUCATION (ISoISE) dalam rangka Visiting and International Conference tahun 2020 dari Dosen dan Mahasiswa Program Magister Pascasarjana UIN Sutha Jambi – Indonesia yang dilaksanakan di Fakulti Pendidikan Universiti Kebangsaan Malaysia - Malaysia pada 20 Februari 202