"Internet + Special Agriculture" Drives Rural Green Revitalization - Investigation and Analysis of Xunwu County, Jiangxi Province

"Internet + agriculture” organically combines Internet technology with traditional agriculture to achieve agricultural transformation and upgrading. Under the strategy of rural rejuvenation, Xunwu County, Jiangxi Province, developed "Internet + characteristic agriculture" according to local conditions, which has optimized the local agricultural scale and characteristic agricultural formats. However, the "Internet + characteristic agriculture" in Jiangxi Province still has problems such as imbalanced structural development, low level of inclusive finance, and insufficient professional talent reserves. It is necessary to promote the industrial and financial development of various agricultural sectors and the Internet, increase policy support for talents to return to their hometowns to start businesses, promote the popularization of Internet finance in rural areas, and adjust the agricultural product trade structure to achieve the common development of various types of crops

Design for Postplacement Mousing based on GSM in Long-Distance

This design for mousing is made up of power control module, infrared sensor module, signal processing module, distance information transportation based on GSM and device of power grid. The design consists of two sets of conductors, separately linked by fire wire and null line and distributing alternatively. The major innovation is infrared sensor module with Fresnel lens, and that the infrared detecting area should be spread in one direction at least. When the mouse get into the infrared detecting area, the sensor signal of infrared detecting device is sent to power control module through signal element and then starts the device of power grid to power up to make the mouse be shocked or die. GSM module is adopted to tell that the mouse is caught successfully. This design can be placed in any position that the mouse is always out and no need of baits

Identification and expression of the TIP subfamily in apple in response to drought stress

Abstract [Objective] This study aims to identify and analyze the members of the tonoplast intrinsic protein (TIP) subfamily in apple, and to investigate the expression patterns under drought stress. It provides information for further research on utilization of drought resistance gene resources in apple. [Methods] The MdTIPs in apple genome was identified by bioinformatics methods. The physicochemical properties, gene structures, conserved motifs, cis-regulatory elements, and phylogenetic trees, etc. of the subfamily members were analyzed. The expression patterns of MdTIPs in different organs under drought stress were analyzed by qRT-PCR. [Results] A total of 13 MdTIP genes were identified in the apple genome, and most members were localized at the plasma membrane. Chromosome localization analysis suggested that all members were distributed on 10 chromosomes, with 1-3 members on each chromosome. Besides, the promoter regions of the genes contained response elements for hormonal and adversity stresses. qRTPCR showed that MdTIP members were up-regulated in roots except MdTIP1;1, of which MdTIP1;3 and MdTIP1;4 were up-regulated 5.27 times and 5.69 times, respectively, compared with the control, suggesting that these two genes might be critical in response to drought stress. [Conclusion] Identification of MdTIP subfamily members is provided in this study. 10 MdTIP members are differentially expressed in roots, stems, and leaves, and 12 members are highly expressed in roots

Machine learning models reveal the critical role of nighttime systolic blood pressure in predicting functional outcome for acute ischemic stroke after endovascular thrombectomy

BackgroundBlood pressure (BP) is a key factor for the clinical outcomes of acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, the effect of the circadian pattern of BP on functional outcome is unclear.MethodsThis multicenter, retrospective, observational study was conducted from 2016 to 2023 at three hospitals in China (ChiCTR2300077202). A total of 407 patients who underwent endovascular thrombectomy (EVT) and continuous 24-h BP monitoring were included. Two hundred forty-one cases from Beijing Hospital were allocated to the development group, while 166 cases from Peking University Shenzhen Hospital and Hainan General Hospital were used for external validation. Postoperative systolic BP (SBP) included daytime SBP, nighttime SBP, and 24-h average SBP. Least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), Boruta were used to screen for potential features associated with functional dependence defined as 3-month modified Rankin scale (mRS) score ≥ 3. Nine algorithms were applied for model construction and evaluated using area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy.ResultsThree hundred twenty-eight of 407 (80.6%) patients achieved successful recanalization and 182 patients (44.7%) were functional independent. NIHSS at onset, modified cerebral infarction thrombolysis grade, atrial fibrillation, coronary atherosclerotic heart disease, hypertension were identified as prognostic factors by the intersection of three algorithms to construct the baseline model. Compared to daytime SBP and 24-h SBP models, the AUC of baseline + nighttime SBP showed the highest AUC in all algorithms. The XGboost model performed the best among all the algorithms. ROC results showed an AUC of 0.841 in the development set and an AUC of 0.752 in the validation set for the baseline plus nighttime SBP model, with a brier score of 0.198.ConclusionThis study firstly explored the association between circadian BP patterns with functional outcome for AIS. Nighttime SBP may provide more clinical information regarding the prognosis of patients with AIS after EVT

Prospective cohort study evaluating efficacy and safety of efgartigimod in Chinese generalized myasthenia gravis patients

BackgroundDespite the efficacy of efgartigimod demonstrated in ADAPT phase 3 trial, data specifically derived from Chinese participants are not available. Therefore, we aimed to evaluate the efficacy and safety of efgartigimod in Chinese patients with generalized myasthenia gravis (gMG).MethodsThis is a prospective cohort study conducted in 8 hospitals across China. gMG patients received weekly intravenous infusions of efgartigimod (10 mg/kg) under a named patient program (NPP). The present study is an 8-week study, consisting of 4 consecutive doses of efgartigimod administered over 3 weeks (one cycle), followed by a 5-week follow-up period to assess the tolerability of efgartigimod’s therapeutic effects. The primary outcome was the mean change in MG activities of daily living (MG-ADL) total score from baseline to 4 weeks. MG-ADL responder was defined as a ≥ 2-point improvement that persisted for 4 weeks, starting by week 4. Safety evaluations encompassed the monitoring of adverse events (AE) and serious AE (SAE) throughout the study.ResultsBetween 5 July 2022 and 25 August 2023, a total of 14 gMG patients were included. The mean age was 57.7 years, with a mean MG-ADL score of 10.86 ± 3.32. At week 4, MG-ADL scores showed a mean reduction of 6 points, reaching a maximum decline of 13 points. Among the patients, 85.7% (12/14) achieved MG-ADL responder status after one cycle of treatment. The most significant reduction in quantitative MG (QMG) scores also occurred at week 4, with a mean decrease of 7 points. Notably, the improvements in MG-ADL and QMG scores persisted until week 8. During treatment and follow-up period, only two mild neck rashes occurred and resolved promptly. No infections or SAE were reported.DiscussionA single cycle of efgartigimod treatment demonstrates effectiveness and the tolerability through week 8, with no new safety signals observed in Chinese gMG patients

Biological Metaphor, Technological Innovation and Industrial Evolution in Jiangxi Province

From the perspective of the study of biological metaphor analysis, this article intends to explore a "high-quality" regional economic development path that fits the context of the economic transition period. This article first introduces the definition of biological metaphors in evolutionary economics. Second, analyzed the inherent logic of the biological metaphor of technological innovation and industrial evolution, and found that the concept of green development must be integrated into the technological innovation process of individual enterprises at the current stage in order to achieve the transformation and upgrading of the current industrial structure. Third, taking Jiangxi Province as an example, the theoretical framework of biological metaphors for creating a beautiful "Jiangxi model" in China was discussed, and the current state of industrial evolution, technological innovation, and environmental regulation in Jiangxi Province from 2011 to 2017 were described in detail. The rationality of the theoretical framework for the analysis of biological metaphors to create a beautiful Jiangxi model in China, that is, it is suitable for the needs of industrial development in Jiangxi Province. Finally, corresponding policy recommendations are given based on the relevant conclusions

Therapeutic potential of dihydroartemisinin in mitigating radiation‐induced lung injury: Inhibition of ferroptosis through Nrf2/HO‐1 pathways in mice

Abstract Background Radiation‐induced lung injury (RILI) is a common consequence of thoracic radiation therapy that lacks effective preventative and treatment strategies. Dihydroartemisinin (DHA), a derivative of artemisinin, affects oxidative stress, immunomodulation, and inflammation. It is uncertain whether DHA reduces RILI. In this work, we investigated the specific mechanisms of action of DHA in RILI. Methods Twenty‐four C57BL/6J mice were randomly divided into four groups of six mice each: Control group, irradiation (IR) group, IR + DHA group, and IR + DHA + Brusatol group. The IR group received no interventions along with radiation treatment. Mice were killed 30 days after the irradiation. Morphologic and pathologic changes in lung tissue were observed with hematoxylin and eosin staining. Detection of hydroxyproline levels for assessing the extent of pulmonary fibrosis. Tumor necrosis factor α (TNF‐α), transforming growth factor‐β (TGF‐β), glutathione peroxidase (GPX4), Nuclear factor erythroid 2‐related factor 2 (Nrf2), and heme oxygenase‐1 (HO‐1) expression in lung tissues were detected. In addition, mitochondrial ultrastructural changes in lung tissues were also observed, and the glutathione (GSH) content in lung tissues was assessed. Results DHA attenuated radiation‐induced pathological lung injury and hydroxyproline levels. Additionally, it decreased TNF‐α and TGF‐β after irradiation. DHA may additionally stimulate the Nrf2/HO‐1 pathway. DHA upregulated GPX4 and GSH levels and inhibited cellular ferroptosis. Brusatol reversed the inhibitory effect of DHA on ferroptosis and its protective effect on RILI. Conclusion DHA modulated the Nrf2/HO‐1 pathway to prevent cellular ferroptosis, which reduced RILI. Therefore, DHA could be a potential drug for the treatment of RILI

Development of 0.34 THz Sub-Harmonic Mixer Combining Two-Stage Reduced Matching Technology with an Improved Active Circuit Model

In this paper, a high-performance 0.34 THz sub-harmonic mixer combining two-stage reduced matching technology with an improved active circuit model is established and analyzed. The mixer’s improved active circuit model is realized by decomposing passive functional models into basic transmission line units and their impedance matching and filtering are realized through automatic optimization. The improved active circuit model takes out the RF (radio frequency) transition model separately to set an optimization goal instead of operating directly in the mixing circuit. Compared with traditional active circuit models in the SDM (subdivision design method) and GDM (global design method), it provides a massive optimization space, larger working bandwidth, and better results. In the RF frequency range of 320–360 GHz, the SSB (single sideband) conversion loss of the 0.34 THz sub-harmonic mixer is below 9.5 dB and the RF return loss is less than 12 dB

Development of 0.34 THz Sub-Harmonic Mixer Combining Two-Stage Reduced Matching Technology with an Improved Active Circuit Model

In this paper, a high-performance 0.34 THz sub-harmonic mixer combining two-stage reduced matching technology with an improved active circuit model is established and analyzed. The mixer’s improved active circuit model is realized by decomposing passive functional models into basic transmission line units and their impedance matching and filtering are realized through automatic optimization. The improved active circuit model takes out the RF (radio frequency) transition model separately to set an optimization goal instead of operating directly in the mixing circuit. Compared with traditional active circuit models in the SDM (subdivision design method) and GDM (global design method), it provides a massive optimization space, larger working bandwidth, and better results. In the RF frequency range of 320–360 GHz, the SSB (single sideband) conversion loss of the 0.34 THz sub-harmonic mixer is below 9.5 dB and the RF return loss is less than 12 dB