102 research outputs found
A Real-time Non-contact Localization Method for Faulty Electric Energy Storage Components using Highly Sensitive Magnetometers
With the wide application of electric energy storage component arrays, such
as battery arrays, capacitor arrays, inductor arrays, their potential safety
risks have gradually drawn the public attention. However, existing technologies
cannot meet the needs of non-contact and real-time diagnosis for faulty
components inside these massive arrays. To solve this problem, this paper
proposes a new method based on the beamforming spatial filtering algorithm to
precisely locate the faulty components within the arrays in real-time. The
method uses highly sensitive magnetometers to collect the magnetic signals from
energy storage component arrays, without damaging or even contacting any
component. The experimental results demonstrate the potential of the proposed
method in securing energy storage component arrays. Within an imaging area of
80 mm 80 mm, the one faulty component out of nine total components can
be localized with an accuracy of 0.72 mm for capacitor arrays and 1.60 mm for
battery arrays
Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer
<p>Abstract</p> <p>Background</p> <p>The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now, the mechanism of carcinogenesis has remained unclear. In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice.</p> <p>Methods</p> <p>Gene expression profiles of spontaneous breast cancer and matched normal mammary gland tissues in TA2 mice were ascertained using an Affymetrix Mouse 430 2.0 array. Twelve mammary tissue samples from five month-old female TA2 mice (Group A), as well as 28 samples from mammary (Group B) and cancer tissues (Group C) of spontaneous breast cancer-bearing TA2 mice, were subsequently used to detect the expression of decorin, EGFR and cyclin D1 by real-time PCR and immunohistochemical methods.</p> <p>Results</p> <p>Several imprinted genes, oncogenes and tumor suppressor genes were differentially expressed between normal mammary gland tissues and breast cancer tissues of TA2 mice. The imprinted gene decorin and the oncogene EGFR were down-regulated in tumor tissues, while the oncogene cyclin D1 was up-regulated. Immunohistochemistry showed that samples in Group A showed high decorin expression more frequently than those in Group B (<it>P </it>< 0.05). More tissue samples in Group B than Group A were positive for nuclear EGFR, and tissue samples in Group B more frequently showed high nuclear EGFR expression than those in Group A or Group C (<it>P </it>< 0.05). The labeling index for cyclin D1 in Group C was significantly higher than in Group B. Mammary tissues of Group A expressed the highest level of decorin mRNA (<it>P </it>< 0.05), and mammary tissues of Group B expressed the highest level of EGFR mRNA (<it>P </it>< 0.05), while cancer tissues expressed the highest level of cyclin D1 mRNA (<it>P </it>< 0.05).</p> <p>Conclusions</p> <p>The expression of decorin, EGFR and cyclin D1 in mammary epithelial cells changes with increasing age. The abnormal expression of them may partly contribute to the genesis of spontaneous breast cancer in TA2 mice.</p
Bubble in the Whale: Identifying the Optical Counterparts and Extended Nebula for the Ultraluminous X-ray Sources in NGC 4631
We present a deep optical imaging campaign on the starburst galaxy NGC 4631
with CFHT/MegaCam. By supplementing the HST/ACS and Chandra/ACIS archival data,
we search for the optical counterpart candidates of the five brightest X-ray
sources in this galaxy, four of which are identified as ultraluminous X-ray
sources (ULXs). The stellar environments of the X-ray sources are analyzed
using the extinction-corrected color-magnitude diagrams and the isochrone
models. We discover a highly asymmetric bubble nebula around X4 which exhibits
different morphology in the H and [O III] images. The [O III]/H
ratio map shows that the H-bright bubble may be formed mainly via the
shock ionization by the one-sided jet/outflow, while the more compact [O III]
structure is photoionized by the ULX. We constrain the bubble expansion
velocity and interstellar medium density with the MAPPINGS V code, and hence
estimate the mechanical power injected to the bubble as erg s and the corresponding bubble age of yr. Relativistic jets are needed to provide such level of mechanical
power with a mass-loss rate of . Besides
the accretion, the black hole spin is likely an additional energy source for
the super-Eddington jet power.Comment: 17 pages, 10 figures, accepted by Ap
Heterologous expression of a Glyoxalase I gene from sugarcane confers tolerance to several environmental stresses in bacteria
Glyoxalase I belongs to the glyoxalase system that detoxifies methylglyoxal (MG), a cytotoxic by-product produced mainly from triose phosphates. The concentration of MG increases rapidly under stress conditions. In this study, a novel glyoxalase I gene, designated as SoGloI was identified from sugarcane. SoGloI had a size of 1,091 bp with one open reading frame (ORF) of 885 bp encoding a protein of 294 amino acids. SoGloI was predicted as a Ni2+-dependent GLOI protein with two typical glyoxalase domains at positions 28–149 and 159–283, respectively. SoGloI was cloned into an expression plasmid vector, and the Trx-His-S-tag SoGloI protein produced in Escherichia coli was about 51 kDa. The recombinant E. coli cells expressing SoGloI compared to the control grew faster and tolerated higher concentrations of NaCl, CuCl2, CdCl2, or ZnSO4. SoGloI ubiquitously expressed in various sugarcane tissues. The expression was up-regulated under the treatments of NaCl, CuCl2, CdCl2, ZnSO4 and abscisic acid (ABA), or under simulated biotic stress conditions upon exposure to salicylic acid (SA) and methyl jasmonate (MeJA). SoGloI activity steadily increased when sugarcane was subjected to NaCl, CuCl2, CdCl2, or ZnSO4 treatments. Sub-cellular observations indicated that the SoGloI protein was located in both cytosol and nucleus. These results suggest that the SoGloI gene may play an important role in sugarcane’s response to various biotic and abiotic stresses
The Mass-Metallicity Relation of Dwarf Galaxies at the Cosmic Noon in the JWST Era
We present the mass-metallicity relation (MZR) at in the stellar mass
range of using 55 dwarf galaxies in
the Abell 2744 and SMACS J0723-3732 galaxy cluster fields. These dwarf galaxies
are identified and confirmed by deep JWST/NIRISS imaging and slitless grism
spectroscopic observations. Taking advantage of the gravitational lensing
effect, we extend the previous MZR relation at to a much lower mass
regime by more than 2.5 orders of magnitude compared with previous studies. We
find that the MZR has a shallower slope at the low-mass end
() compared to that at the high-mass end
(), with a slope turnover point at around the stellar
mass of . This implies that dominating feedback processes in
dwarf galaxies may be different from that in galaxies with higher mass. From
to , the metallicity of the dwarf galaxies is enhanced by
dex for a given stellar mass, consistent with the mild evolution
found in galaxies with higher mass. Further, we confirm the existence of a 3D
relation between the gas-phase metallicity, stellar mass, and star formation
rate, i.e., fundamental metallicity relation (FMR), in dwarf galaxies at
. Our derived FMR, which has no significant redshift evolution, can be
used as a benchmark to understand the origin of the anti-correlation between
SFR and metallicity of dwarf galaxies in the high-redshift Universe.Comment: 16 pages, 4 figures, 1 table, submitted to AAS Journal; welcome
comment
Searching for C ii Emission from the First Sample of z ∼ 6 O i Absorption-associated Galaxies with the Atacama Large Millimeter/submillimeter Array
We report the first statistical analyses of [C ii ] and dust continuum observations in six strong O i absorber fields at the end of the reionization epoch obtained by the Atacama Large Millimeter/submillimeter Array (ALMA). Combined with one [C ii ] emitter reported in Wu et al., we detect one O i -associated [C ii ] emitter in six fields. At redshifts of O i absorbers in nondetection fields, no emitters are brighter than our detection limit within impact parameters of 50 kpc and velocity offsets between ±200 km s ^−1 . The averaged [C ii ]-detection upper limit is 50 kpc) and having larger outflow velocities within ±600 km s ^−1 . If these detections are confirmed in the future, then the mechanism of pushing metals at larger distances with higher velocities needs to be further explored from the theoretical side
Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer
The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer
Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry
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