Synthesis and Characterization of Chalcones and Pyrazolines derived from Substituted Aryl ether

Few novel chalcones were synthesised by treating 4-fluoro-3-phenoxy benzaldehyde with different substituted ketones and characterised using 1H NMR and mass spectrometry. The chalcones synthesised were further treated with hydrazine hydrate to get corresponding pyrazolines. The newly synthesised pyrazolines were characterised by 1H NMR and mass spectrometry

Synthesis of biologically active 4-amino-6-arylmethyl-3-mercapto-1, 2, 4-triazin-5(4H)-ones and their Schiff bases

943-94

2-(2-Methoxy­phen­yl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

In the title mol­ecule, C12H15NO2, the oxazole ring adopts an envelope conformation. Overall, the mol­ecule is approximately planar, the dihedral angle between the mean plane through all but the methyl­ene C atom of the five-membered ring and the aromatic ring being 8.6 (1)°. A weak C—H⋯O inter­action contributes to the stabilization of the crystal structure

Synthesis and antibacterial activity of nitro-furylvinylquinazolinones

715-71

(2E)-1-(4-Methyl­phen­yl)-3-(2,3,5-trichloro­phen­yl)prop-2-en-1-one

In the title mol­ecule, C16H11Cl3O, the dihedral angle between the two benzene rings is 33.2 (1)°. The crystal packing is stabilized by C—H⋯O hydrogen bonds

One pot synthesis of some new biologically active arylfurylthiadiazolotriazinones^†

2690-26934-Amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 1 are condensed with 5-aryl-2-furoic acids 2 to yield 7-(5-aryl-2-furyl)-3-arylmethyl-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones 3 employing phosphorus oxychloride as a cyclizing agent in one pot synthesis. Similarly, 7 -(5-aryl-2-furyl)-3-(t-butyl)-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones 5 have been synthesized. All the newly synthesized thiadiazolotriazinones 3 and 5 have been tested for their antibacterial activities against E.coli, S.aureus, P.aeruginosa and B.subtilis and their MIC values are determined. Compounds 3a-c have been found to be promising antibacterial agents

Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines

3113-3116Methyl aryl ketones 1 on reaction with 5-nitrofurfuraldehyde 2 give l-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 3 which on bromination affords 2,3-dibromo-1-aryl-3-(5-nitro-2-furyl )-2-propen-1-ones 4. Debromination of 4 by triethylamine in benzene results in 1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 5 which on condensation with 3-substituted-4-amino-5-mercapto-1,2,4-triazole 6 furnishes Michael adducts 7. The Michael adduct 7 undergoes cyclization in conc. sulphuric acid to give 3-aryloxymethyl-6-aryl-8-(5-nitro-2-furyl)-1,2,4-triazolothiadiazepines 8. Antibacterial activity of 7 and 8 has been reported

Synthesis and antibacterial activity of <i style="mso-bidi-font-style:normal">N</i>-bridged heterocycles derived from aryloxymethyltriazoles

1257-1262Reactions of 3-aryloxymethyl-4-amino-5-mercapto-1 ,2,4-triazoles 1 with aromatic carboxylic acids, furoic acid, oxalic acid, monochloroacetic acid and phenacyl bromide furnish various N-bridged heterocycles viz., triazolothiadiazoles, bis-triazolothiadiazoles, triazolothiadiazinones and triazolothiadiazines. The structures of these N-bridged heterocycles are characterized on the basis of elemental analyses, IR, NMR and mass spectral data. Some of these compounds are also subjected to antibacterial screening studies

Synthesis of some new biologically active triazino-thiadiazinones

475-478A series of 4H, 8H-1,2,4-triazino[3,4-b]-1,3,4-thiadiazin-4-ones 3a-i have been synthesized by the reaction of 4-amino-6-substituted-3-mercapto-1 ,2,4-triazin-5(4H)-ones 1 with substituted phenacyl bromides 2. These newly synthesized compounds have been tested for antimicrobial activities

Synthesis and biological activity of some bis-triazole derivatives⁺

2010-2014A series of bis-(4-amino-5-mercapto-triazol-3-yl)alkanes, their Schiff bases and bis-(1,2,4-triazolo[3,4-b]-1,3,4-thiadiazol-4-yl)alkanes have been synthesized. The newly synthesized compounds have been screened for their antibacterial properties.Compounds 5h and 9f exhibit greater degree of antibacterial activity than the standard, Furacin