11 research outputs found
Lipid peroxidation and antioxidant systems in the blood of young rats subjected to chronic fluoride toxicity
857-860Wistar
albino rats were
exposed to
30 or 100
ppm fluoride in drinking
water during
their fetal,
weanling and postweaning
stages of life
up to puberty.
Extent of lipid
peroxidation
and response
of the antioxidant
systems
in red blood cells
and plasma to
prolonged fluoride
exposure were
assessed in these rats in
comparison
to the eontrol
rats fed with permissible
level (0.5
ppm) of fluoride.
Rats treated
with 100 ppm fluoride
showed enhanced
lipid peroxidation
as evidenced
by elevated
malondialdehyde (MDA)
levels in
red blood
cells but, 30
ppm fluoride
did not cause
any appreciable
change in RBC
MDA level. 30
ppm fluoride-
intake resulted
in increased
levels of total
and reduced
glutathione
in red blood cells
and ascorbic acid
in plasma while 100
ppm fluoride resulted
in decreases in
these levels.
The activity
of RBC glutathione
peroxidise was elevated
in both the
fluoride-treated
groups,
more pronounced
increase was
seen with 100
ppm. Reduced
to total glutathione
ratio in RBC
and uric acid levels
in plasma decreased
in both the groups. RBC superoxide
dismutase
activity
decreased significantly
on high-
fluoride treatment.
These results
suggest
that long-term
high- fluoride
intake at
the early developing
stages of life
enhances oxidative
stress in
the blood, thereby
disturbing the
antioxidant defense
of rats.
Increased oxidative
stress could
be one of
the mediating
factors in the
pathogenesis
of toxic
manifestations
of fluoride