DIGITAL CULTURE – A HISTORICAL STAGE IN THE DEVELOPMENT OF THE INFORMATION CULTURE OF SOCIETY

Different scientific approaches to digital culture have been analysed in the article: digital culture is considered as a special form of being, a special integral design that includes audiovisual, semiotic, technological, logical, communication, network and other subsystems that exists at five levels: material, functional, symbolic, mental and spiritual; and as a set of values ofmodern society based on digital coding; and as a system of changes in practices, products of human activity associated with the culture of the digital age; and as a special level of digital literacy and competency. The anthropological aspect of digital culture has been emphasized. The main causes and stages of the development of digital culture as a modern stage in the development of the information culture of society also have been considered

Managing academic mobility as a tool of «soft power» in contemporary China

The paper deals with the phenomenon of academic mobility in the context of internationalization of higher education in modern China. It focuses on such problems as specificity of Chinese approach to internationalization of higher education and functioning of academic mobility in the context of transformation of international educational space. It is shown that the image of the future educated China is based on the traditional project of “Great Unity” society (Datong society in Confucian concept of social ideal). At the same time the idea of a united humanity is not exceptionally Chinese, but has deep historical roots and a universal nature. Cautious about the supranational extrapolation of this idea, modern China is nevertheless expanding international cooperation and strengthening cross-national contacts, using cross-border academic mobility as one of its “soft power” tools

THE ISSUE OF “CULTURAL AMNESIA” IN THE CONTEXT OF DIGITAL CULTURAL HERITAGE MANAGEMENT

The issue of the dual impact of innovative technologies on the sphere of spiritual culture has been considered. On the one hand, the digitalization of cultural values gives hope for their longevity, compared with traditional storage methods. On the other hand, the preservation of cultural heritage is facing new, previously unmet difficulties: the life of digital documents is short due to constant technological improvement and the rapid obsolescence of technology; not all artifacts can be digitized; when knowledge is transmitted through the media, its reduction, vulgarization occurs; finally, the person is changing, for whose sake the preservation of the cultural heritage takes place. Generations possessing clip thinking will have to deal with the fragmented, unsystematic cultural heritage, which is fraught with real cultural amnesia. The new approaches to digital information management and, specifically, digital cultural heritage have been proposed in the article

Transforming educational space under the impact of the pandemic: student and teacher well-being in higher education

The article presents the study of some areas of educational space transformation under the COVID-19 pandemic influence. The focus of attention is on such problems as the cognitive well-being of the student, the tutor model of teacherstudent relations in the digitalising educational space, the functioning of academic mobility institution in a pandemic and post-pandemic world. Cognitive well-being of students implies mastering digital literacy with strict adherence to the norms of digital ethics. A tutor in modern education plays the role of not only a developer of an individual educational trajectory, but also a controller and educator. For the successful implementation of tutoring functions, the teaching staff of universities needs additional training. The main trends in academic mobility are internal and virtual mobility. The authors conclude that educational organisations need for adequate infrastructural policy, and educational space – inevitable transformations in budget financing. The results of the article can be used in further research on the higher education transformation problems, in the development of proposals and recommendations for specialists in the of higher education management field for use in practice

SOCIOLOGY OF KNOWLEDGE SECURITY IN THE DIGITAL EDUCATIONAL SPACE

The article deals with the spread of digital technologies in education and digital learning as a special stage of digital socialization, changing the social roles of the teacher and student. Artificial intelligence and machine learning technologies, big data analysis, robotics and virtualization have taken their place in the educational process, and traditional offline teaching methods require revision. The problem of knowledge alienation in the digital educational space has been analysed and ways to solve this problem have been proposed. Particular attention has been paid to the problem of the safety of knowledge in the educational space. It has been concluded about the need for such a reorganization of the digital space in which cognitive conditions for the safe functioning of knowledge will be provided

LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS

Aim of the study was to identify the mechanism of specific endothelial toxicity related to calcium phosphate bions (CPB). Material and methods. CPB and magnesium phosphate bions (MPB) were artificially synthesised through supersaturation of culture medium with respective salts and then added to human endothelial cells (EA.hy 926) and murine endothelial cells (2H-11) to study: 1) spatiotemporal aspects of bion internalisation by means of transmission electron microscopy and confocal microscopy; 2) whether blocking of H+-ATPase by lysosomal inhibitor bafilomycin A1 affects endothelial toxicity of bions; 3) expression of caspase-3 and its substrate poly(ADP-ribose) polymerase (PARP-1). Results. CPB were internalized by endothelial cells as early as 1 h upon their addition and were localized in lysosomes; after 4 h, we detected release of calcium ions (Ca2+) from lysosomes to cytosol accompanied by multifold increase in cleaved caspase 3 and its substrate PARP-1. Bafilomycin A1 rescued endothelial cells from death induced by slightly soluble CPB regardless of exposure time and dose; however, freely soluble MPB did not evince endothelial toxicity regardless of bafilomycin A1 addition. Conclusion. Upon internalization by endothelial cells, CPB cause their death due to dissolution in lysosomes and subsequent release of calcium ions into the cytosol, ultimately leading to cleavage of executioner caspases. MPB lack endothelial toxicity because their dissolution does not lead to release of calcium ions. Therefore, specific endothelial toxicity of CPB is defined by lysosome-dependent cell death

Quantification of the initial levels of calciprotein particles as a screening marker of mineral homeostasis in patients with cardiovascular disease and in patients with chronic kidney disease

Aim. To evaluate the initial concentration of calciprotein particles (CPPs), which are scavengers of excessive calcium and phosphate, in patients with cardiovascular disease and in patients with chronic kidney disease as compared with the healthy volunteers.Material and methods. The study included 308 individuals as follows: 1) 88 participants of the PURE study without hemodynamically relevant carotid athero scle rosis and symptomatic coronary atherosclerosis; 2) 88 patients with cere brovascular disease (CVD) who required carotid endarterectomy; 3) 88 pa tients with coronary artery disease (CAD) who required percutaneous coronary intervention or coronary artery bypass graft surgery; 4) 63 patients with stage 5 chronic kidney disease (CKD). We measured following mineral homeostasis parameters: total and ionized calcium, phosphate, total protein, albumin, and fetuin-A. Then, we determined a baseline serum CPP concentration by flow cytometry using a fluorescent-labeled bisphosphonate OsteoSense 680EX. Results. In comparison with other patients, healthy volunteers had the highest serum CPP concentration (249 CPPs/µL), indicating the retained ability to compensate mineral homeostasis disturbances by aggregation of excessive calcium and pho sphate with acidic proteins (mineral chaperones). Reduced serum CPP concentration in patients with CVD (170 CPPs/µL), CAD (139 CPPs/µL), and stage 5 CKD (193-203 CPPs/µL) showed impaired aggregation of excessive serum calcium and phosphate, which was also reflected by an increased level of blood ionized calcium.Conclusion. Patients with CVD, CAD, and stage 5 CKD have lower serum CPP concentration than healthy individuals. In combination with elevated ionized calcium and reduced albumin, this suggests the depletion of calcium binding buffers in the serum of patients with cardiovascular and renal diseases

Современные аспекты поражения центральной нервной системы у больных ВИЧ-инфекцией (обзор литературы)

The literature review highlights modern ideas about the pathogenesis, pathomorphology, and clinical manifestations of central nervous system damage in patients with HIV infection, and also touches on the problems of diagnosis and treatment of these opportunistic infections. Particular attention should be paid to patients with severe immunodeficiency (CD4+T-lymphocyte count < 200 cl/ml) due to the high risk of secondary diseases of the central nervous system. Along with the etiological verification of opportunistic diseases of the central nervous system, magnetic resonance imaging of the brain is important at the initial stage of diagnosis, with the help of which it is possible to identify changes in the brain substance characteristic of certain pathogens. In addition to the basic etiotropic therapy of opportunistic infections in HIV patients, effective antiretroviral therapy and its index of penetration into the central nervous system play a crucial role.В обзоре литературы освещаются современные представления о патогенезе, патоморфологии, клинических проявлениях поражения центральной нервной системы у больных ВИЧ-инфекцией, а также затрагиваются проблемы диагностики и лечения данных оппортунистических инфекций. Особое внимание следует уделять пациентам с тяжелым иммунодефицитом (количество CD4+Т-лимфоцитов ≤ 200 кл/мкл) в связи с высоким риском развития вторичных заболеваний центральной нервной системы. Наряду с этиологической верификацией оппортунистических заболеваний центральной нервной системы, важное значение на начальном этапе диагностики имеет магнитно-резонансная томография головного мозга, с помощью которой можно выявить характерные для определенных возбудителей изменения в веществе головного мозга. Помимо базовой этиотропной терапии оппортунистических инфекций, у больных ВИЧ-инфекцией решающую роль играют эффективная антиретровирусная терапия и ее индекс проникновения в центральную нервную систему

Borderline personality traits in older adolescents as a predictor of social anxiety

The purpose of the study is to assess the severity of borderline personality traits in older adolescents and their relationship with anxiety and depression.Цель исследования – оценить выраженность черт пограничной личности у старших подростков и их взаимосвязь с тревожностью и депрессивностью

Structural features of the process of formation of neutrophilic granulocytes networks extracellular DNA at a meeting with larynx carcinoma tumor cells

Neutrophilic granulocytesas a permanent structure in the tumor microenvironment play an ambiguous role in oncogenesis. In response to microbial and non-microbial stimuli neutrophils actively formed in the extracellular space net-like structures composed of nucleic acids and enzymes-neutrophil extracellular trap. We have observed that in tumor tissue near the larynx carcinoma tumor cells spread diffusely and clusters of extracellular DNA.Нейтрофильные гранулоциты, являясь постоянной структурой в микроокружении опухолей, играют неоднозначную роль в онкогенезе. В ответ на микробные и немикробные стимулы нейтрофилы активно формируют во внеклеточном пространстве сетеподобные структуры, состоящие из нуклеиновых кислот и ферментов - нейтрофильные внеклеточные ловушки. Нами было замечено, что в ткани опухоли карциномы гортани рядом с опухолевыми клетками диффузно и скоплениями распределяется внеклеточная ДНК