Significance of occult neoplastic cells on tumor metastasis: a case report of gastric cancer

<p>Abstract</p> <p>Background</p> <p>Occult neoplastic cells (ONCs) are the tumor cells floating in the lymph node sinuses, distant from the primary tumor, and supposed to be one of most reliable marker of prognosis.</p> <p>Methods</p> <p>We report here the case of a 52-year-old woman with a gastric cancer associated by numerous ONCs.</p> <p>Results</p> <p>Postoperative examination of the stomach disclosed an advanced, poorly differentiated adenocarcinoma with frequent lymph node metastases. In addition to ONCs and occasional micrometastases, focal aggregates of ONCs, one of the possible intermediate lesions between the ONCs and the usual metastases, are also observed.</p> <p>Conclusions</p> <p>In the present case, at least some of ONCs seem to form the microaggregates of tumor cells in lymph nodes, anchor in the sinuses, and grow up to the large tumorous lesion. Even if most of the ONCs were trapped and disappeared under the influence of tumor immunity, the detection of ONCs could be one of the reliable clues to estimate the prognosis.</p

Gallbladder adenocarcinoma with human chorionic gonadotropin: a case report and review of literature

<p>Abstract</p> <p>Background</p> <p>The case of adenocarcinoma with human chorionic gonadtropin (HCG), primary in the male gallbladder, is extremely rare. A Medline search has shown only a few similar cases reported.</p> <p>Methods</p> <p>We herein describe a case of primary gallbladder adenocarcinoma associated by ectopic HCG positive tumor cells in a 79-year-old male.</p> <p>Results</p> <p>Pathological examination showed a mixture of moderately and poorly differentiated adenocarcinoma with ectopic HCG and placental alkaline phosphatase (PlAP) in tumor cells, though the increase of serum or urinary HCG secretion was not confirmed. The literatures were also reviewed.</p> <p>Conclusions</p> <p>A case of gallbladder cancer with ectopic HCG production is quite rare in the literature, though many similar cases in other site, especially in GI tract, are reported. Embryological consideration suggests the increased frequency of similar cases more than being thought now.</p

ヒトツ ノ クッセツ モンダイ

Abstract　A condition on the point of refraction is stated in connection with the rank of matrices (Main Theorem) As an application a condition on the points of refraction of light is given.　　ｎ＋１次元の実ベクトル空間でｆ（ｘ，ｙ，ｙ’）はｍ個の超曲面の交わりπを境として不連統とし，その両側では必要な条件を満足するものとする。双方の側の２定点Ａ，Ｂがあるときπ上の１点Ｐを求めて，Ａ，Ｐ，Ｂを通るｙ（ｘ）を求めて　　　∫^b_a（ｘ，ｙ，ｙ’）ｄｘ　を極小とする。Ｐの満足すべき条件として行列の階数についての条件を求める。(主定理)　応用として光の屈折問題について考察する