How many hot days and heavy precipitation days will grandchildren experience that break the records set in their grandparents’ lives?

孫は祖父母が遭遇しないような暑い日と大雨を何度経験するのか? --極端な気象現象の変化に関する世代間不公平性とその地域間不公平性の評価--. 京都大学プレスリリース. 2021-06-14.One of the major barriers to climate communication is that climate change is often presented to the public in such a way that impacts seem distant in time. To improve how climate change resonates with people, we propose a simple indicator: how many extreme events (hot days and heavy precipitation days) are grandchildren projected to experience that their grandparents will not experience in their lives? We analyse the Coupled Model Intercomparison Project Phase 6 ensemble. During grandchildren's lifetime (2020–2100) under the shared socioeconomic pathway 5–8.5 (SSP5-8.5), in some tropical regions, they are projected to experience >1000 hot days and >5 heavy precipitation days breaking records set in their grandparents' lifetime until 2040. These numbers of unprecedented hot days and heavy precipitation days under SSP5-8.5 are greater in countries with lower CO₂ emissions and income per capita than in countries with higher CO₂ emissions and income per capita. We show that not only the numbers of unprecedented hot days and heavy precipitation days but also their unevenness across countries can be significantly lowered in the SSP1-2.6 scenario, which is consistent with the 2 °C goal of the Paris Agreement. This new approach would help adults easily understand how their climate change mitigation efforts could decrease the unprecedented extreme events during youths' lifetime and reduce the intergenerational and intragenerational inequalities regarding extreme events

カガク データ カチョウカ プロジェクト プロジェクト タチアゲ ト ショキ データ コウカイ

We report on the current status of our astronomical data sonification project. This project aims to sonify astronomical data, that is, to convert a visual medium into an audio medium for both scientists and the visually impaired. We hope that sonification can lead to a new way of conceptualizing scientific data. The primary sourcesof the data used for this project come from Japanese satellites dedicated to X-ray astronomy and geophysics. This project is performed in collaboration with Nihon Fukushi University and the Center for Planning and Information Systems (PLAIN center) of the Japan Aerospace Exploration Agency (JAXA) Institute of Space andAstronautical Science (ISAS). Our project began in March 2006. Since this time we have sonified astronomical data sets, including data from X-ray pulsars, and have published these results. In this paper we also discuss future plans for the project, as well as its implications for visually impaired scientists and public

Effect evaluation of freeze-thaw on resilient modulus of unsaturated granular base course material in pavement

This study examines the effects of freeze-thaw and water content on the resilient deformation characteristics of subbase course materials to evaluate the mechanical behavior of granular base in cold regions. A series of resilient modulus tests on subbase course materials under various water contents were conducted using a newly developed test apparatus. Besides, the test results were compared with the results of freeze-thaw CBR tests and the long-term field measurement at a model pavement structure including FWD tests. As the results, it was revealed that the resilient deformation characteristics of unbound granular base materials (UGBMs) deteriorate due to freeze-thaw and increment of the water content in thawing season. This indicates that the freeze-thaw of granular base has a strong influence on the fatigue life of pavement structures

A giant popliteal lipoblastoma in a 23-month-old girl: a case report

Abstract Background Lipoblastomas are rare benign tumors that arise from embryonic white fat and almost always occur in babies and children. Here, we report a case of a giant popliteal lipoblastoma in a 23-month-old Japanese girl that was successfully treated via complete resection. Case presentation Our patient was a 23-month-old Japanese girl. At 6 months of age, she presented at a nearby hospital with a mass on the popliteal side of her lower right leg. She had no symptoms and was diagnosed as having a benign adipose tumor via magnetic resonance imaging. The mass gradually increased in size, and she was referred to our hospital at 1 year and 11 months of age. A physical examination and radiology revealed a localized mass 13 × 10 × 7 cm in size in the aforementioned area that restricted knee movement and caused proximal tibia deformity. Magnetic resonance imaging showed a giant circumscribed subcutaneous mass with multiple partitions that was hyperintense on T1-weighted and T2-weighted images but not fat-saturated on T2-weighted images. Based on these findings, she was diagnosed as having a lipoblastoma. Because the mass surrounded her popliteal artery and vein and part of the popliteal nerve, surgical resection was considered risky, and we opted to simply observe her. However, owing to rapid growth of the mass and the worsening of symptoms, she underwent complete resection at 2 years and 6 months of age. A histological examination confirmed the diagnosis of a lipoblastoma. She was discharged from our hospital 3 days after surgery with no symptoms. She could walk without pain at the 6-month follow-up, and no local recurrence was observed. Conclusions We successfully treated a giant popliteal lipoblastoma without complications by performing a total resection. Our report provides evidence that lipoblastomas should be considered for surgical resection when they progress or symptoms appear

Establishment of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3) and Monosomy 7

Abstract. Acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) with both inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7 defines an extremely aggressive myeloid cancer whose molecular pathogenesis and optimal therapeutic strategy still remain unclear. We established a new MDS/AML cell line, YCU-AML1, and its patient-derived xenograft (PDX) model from a high-risk MDS patient who later transformed into AML harboring both t(3;3)(q21;q26.2) and monosomy 7. YCU-AML1 cells propagated in co-culture system with stromal cells in granulocyte macrophage colony-stimulating factor (GM-CSF)-dependent manner. CD34+ bone marrow cells derived from our PDX model showed high EVI1 and low GATA2 expression. Moreover, mutational profile of our MDS/AML model was consistent with recently published mutational spectrum of myeloid malignancies with inv(3)/t(3;3). These data suggest that YCU-AML1 cells and its MDS/AML model strongly mimics a high-risk human myeloid cancer with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7 in terms of both clinical phenotype and molecular basis. We believe our model can be used as a feasible tool to further explore molecular pathogenesis and novel treatment strategy of high-risk MDS/AML with t(3;3)(q21;q26.2) and monosomy 7

Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment

BackgroundLymphoproliferative disorder (LPD), including malignant lymphoma, is a relatively rare but life-threatening complication in RA patients under methotrexate (MTX) therapy. Spontaneous regression of LPD after MTX withdrawal is regarded as a distinct characteristic in part of such LPDs.ObjectiveThe present study aimed to investigate the immunological difference in regressive LPD and persistent LPD.MethodsWe studied RA patients who developed LPD during MTX administration (n = 35) and clinically matched controls (n = 35). The time of MTX cessation was defined as week 0, and LPD patients were divided into two groups according to LPD status at week 12: regressive group (n = 22) and persistent group (n = 13). Flow cytometric analysis of whole blood samples and serum cytokine assays were conducted for LPD (n = 10) and control patients (n = 10) at weeks 0, 4, and 12.ResultsThere was a significant decrease in peripheral lymphocytes and the proportion of T helper 1 cells (Th1 cells), effector memory CD8+ T cells (EMCD8+ T) and Epstein–Barr virus (EBV)-specific CD8+ T cells at the time of LPD diagnosis, and a significant increase after MTX cessation was observed in the regressive group but not in the persistent group. The expansion of Th1 cells and EMCD8+ T cells significantly correlated with an increase in serum interferon (IFN)-γ concentration.ConclusionChanges in Th1 cells, EMCD8+ T cells and EBV-specific CD8+ T cells, which coincided with an increase in IFN-γ, were significantly different between regressive LPD and persistent LPD after MTX cessation