Hall effect in cobalt-doped TiO2−δ_{2-\delta}

We report Hall effect measurements on thin films of cobalt-doped TiO$_{2-\delta}$. Films with low carrier concentrations (10$^{18}$ - 10$^{19}$) yield a linear behavior in the Hall data while those having higher carrier concentrations (10$^{21}$ - 10$^{22}$) display anomalous behavior near zero field. In the entire range of carrier concentration, n-type conduction is observed. The appearance of the anomalous behavior is accompanied by a possible structural change from rutile TiO$_{2}$ to Ti_[n}O$_{2n-1}$ Magneli phase(s)

SOLID LIPID NANOPARTICLES: A PROMISING APPROACH FOR COMBINATIONAL DRUG THERAPY IN CANCER

Combination therapy for cancer treatment is accepted worldwide due to the generation of synergistic anticancer effects; restrain in multidrug resistance (MDR) or tumor resistance by different mechanisms of action and minimization of dose-dependent toxicity. Recently developed Solid lipid nanoparticles (SLNs) are matrix composed of lipid which is solid at both room and body temperature and hence it is as an alternative to other nanocarrier systems. SLNs after oral administration get absorbed by lymphatic pathway due to stimulation of chylomicron formation. Thus, it avoids all consequences related to an oral drug delivery system and improves oral bioavailability. SLNs based combination drug delivery to tumor tissues reduces the problems associated with chemotherapy. The targeted and sustained delivery of chemotherapeutic agents reduces the dose by achieving high concentrations at the target site, without altering the normal tissues. In this article, we have reviewed and focused on SLNs as a drug delivery system; ingredients used in formulating SLNs and developed two or more drugs in a single formulation of SLNs as drug delivery. This article also focuses on the fact that SLNs as a combination drug delivery provides an attractive approach in future prevention and beneficial for the treatment of cancer by increasing its therapeutic efficacy

Export of proteins across membranes: the helix reversion hypothesis

A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export

Biometric Security System for Newborn Baby

Newborn swapping and abduction in hospitals are challenging issues which occurs all over the world. Traditional method to combat this problem have their own drawbacks, here areal time solution is provided by proposed modal havRfive modules on raspberry Pi. Implemented module consisting of one camera for providing real time security against culprit who lifts the baby from cradle. Additionally a temperature sensor is used which gives the continuous updates about the baby�s health to medical staff and parents. The results of implemented modules shows that we can get the real time alert about culprit which will be easy to find out person who lifts the baby from cradle and also continuous data of temperature of baby�s body of providing time to time attention towards health. Proposed system has modules for scanning and matching of footprints of baby and hand impression of mother which provide a low cost solution to the newborn swapping rather than the expensive DNA procedures

Seasonal variations of protein in the ovary of fish Channa gachua

          The present study was carried out in the breeding seasons from 2004 to 2006. The ovary of fresh water fish Channa gachua was analyzed for its protein content during period of four different phases of reproductive cycle, in Channa gachua i.e. preparatory, pre-spawning, and post-spawning. Protein content found in preparatory phase was non significant, and significantly increased from pre-spawning to spawning and declined in post-spawning (mg/g wet weight of ovary)

The Science of Safety – An Emerging Concept in Medication Use and Research

Most published reports of patient safety in clinical practice focus largely on the culture of safety in complex health systems, separate from pre-approval and postmarketing research-related safety considerations for drugs, biologics, and other medical products. The science of safety requires a linked integrated perspective, i.e., an iterative process examining and relating safety concerns from drug or biologic discovery and development in preclinical stages, clinical trials and post-market use, research, surveillance, and potential regulatory changes. This commentary addresses the science of safety across the lifecycle of drug and biological products, regulatory considerations, barriers, and research needs. This paper provides a brief overview on how the functioning of healthcare systems affects the safety environment and describes how stakeholder involvement, research participation, and targeted education and training can help facilitate better safety measures and practices, provide improved quality of care to patients, and contribute to the science of safety. Conflict of Interest We declare no conflicts of interest or financial interests that the authors or members of their immediate families have in any product or service discussed in the manuscript, including grants (pending or received), employment, gifts, stock holdings or options, honoraria, consultancies, expert testimony, patents and royalties".   Type: Commentar

Optical band edge shift of anatase cobalt-doped titanium dioxide

We report on the optical properties of magnetic cobalt-doped anatase phase titanium dioxide Ti_{1-x}Co_{x}O_{2-d} films for low doping concentrations, 0 <= x <= 0.02, in the spectral range 0.2 to 5 eV. For well oxygenated films (d << 1) the optical conductivity is characterized by an absence of optical absorption below an onset of interband transitions at 3.6 eV and a blue shift of the optical band edge with increasing Co concentration. The absence of below band gap absorption is inconsistent with theoretical models which contain midgap magnetic impurity bands and suggests that strong on-site Coulomb interactions shift the O-band to Co-level optical transitions to energies above the gap.Comment: 5 pages, 4 figures, 1 table; Version 2 - major content revisio