A CONTROLLED CLINICAL STUDY ON ROLE OF “DHATRI LOHA YOGA†IN KAMALA WITH SPECIAL REFERENCE TO HYPERBILIRUBINAEMIA

Ayurved system mainly deals with digestion and associated metabolic methods. Liver i.e. Yakrita is the Moolasthana of Pachak Pittas, Raktavaha strotasa. Which we can correlate with Hepatobiliary system. Disturbance or diseases of hepatic system leads to mortality all the way through failure of remaining systems of our body. Kamala is one of the most important and specified disease of Yakrita which can be correlated with Hyperbilirubinemia or Jaundice.Hyperbilirubinemia is a primary sign of disturbed Liver function. Liver disease is 8th leading cause of death worldwide. 50% of patients with Liver cirrhosis and 70% with cirrhosis plus alcoholic hepatitis die within 48 months. Overall, cirrhosis is the 4th leading cause of death. The overall mortality of acute viral hepatitis is 0.5% under the age of 40 yrs. and 3% in patients over 60 yrs. In which mortality rate of HAV and HEV is 0.5%, HBV is less than 2% and that of HCV is 0.5 -1%. Most of the patients develop chronic infection after acute hepatitis which continues for lifetime. Taken as a whole Hepatitis not only disturbs mental, physical health of patient but also social, economical, cultural and family life of a person.In present study Dhatri Loha Yoga from Ayurvedic granthas tested along with proven efficient drug Kutki over Kamala (Hyperbilirubinemia). Dhatri Loha Yoga is a combination of drugs which directly deals with bilirubin metabolism. Dhatri LohaYoga significantly reduces symptoms of Kamala upto 94.2 % which is very favorable. It shows reduction in Sign, Symptoms, and Specific biochemical markers like SGPT, SGOT, and Serum Bilirubin. From the statistical analysis through Chi-square Test the two-sided P value is < 0.0001, Thus Dhatri loha yoga is extremely significant in the management of Kamala and regulating bilirubin metabolism

A CLINICAL STUDY TO EVALUATE THE EFFICACY OF TRITIYA ALAMBUSHADI CHURNA IN MANAGEMENT OF AMAVATA

Amavata is a chronic disease. Due to tremendous pain in Amavata, patients daily life get disturbed. Also the morbidity of disease disturbs routine work of the patient. The sign and symptoms of Amavata is nearer to resemble with Rheumatoid arthritis in modern science, R.A is more than just arthritis. The prevalence of R.A. is approximately 0.8% of the population (range 0.3 to 2.1%), woman are affected three times more often than man. Family studies indicate a genetic predisposition. Now a days, due to changed life style and improper dietary habits like pattern of spicy food, irregular timing of meals, over eating etc. causes Agnimandya and it leads to production of Ama. All these faulty eating habits are almost always accompanied with faulty vihara like improper or over exercise, late night parties, suppression of natural urges, excessive traveling etc. these are causes of vitiation of Vata. This vitiated Vata carries Ama to the all over the body especially the Kapha sthanas and produces symptoms like Sandhi shotha, Sandhi shula, Stabdhata1 (stiffness) and other systemic sign and symptoms. This dreadful disease is called as Amavata.Tritiya Alambushadi Churn provided highly significant relief in pain (73.41%). joint score (59.26%), tenderness (73.91%), stiffness (76.22%), swelling of joints (78.53%), local temperature (77.61%) and improvement in grip strength (73.61%),functional activity (79.66%). i.e. overall total improvement is 73.63%. On the basis of these observations, administration of Tritiya Alambushadi Churna is effective for the management of Amavata

Hypoglycemic and Hypolipidemic Effect of Sida rhombifolia ssp. retusa in Diabetic Induced Animals

In the present study, the anti-diabetic effect of aqueous extract of Sida rhombifolia ssp. retusa (Malvaceae) leaves was studied in normal and streptozotocin (STZ)-induced (60 mg/kg, single intraperitoneal injection) diabetic rats. Hypoglycemic activity in normal rats was tested after administration of 200 mg/kg of extract.Aqueous extract showed a 15% reduction in plasma glucose level after 1.5 h of extract administration. When tested in STZ-induced diabetic rats the reduction in plasma glucose was 17%. In oral glucose tolerance test in normal rats and STZ-induced rats the decrease in AUC was 15 and 7% respectively. Glibenclamide was used as reference drug and showed significant hypoglycemic effects in normal rats but had marginal activity in STZ-induced diabetic rats. In hypolipidemic study a dose of 200 mg/kg of aqueous extract has shown reduction in triglycerides (TG) (16%), cholesterol (4%), and glucose level (10%). Fenofibrate was used as standard drug for hypolipidemic study.The results obtained from the experiment provided scientific evidence in favor of the traditional use of Sida rhombifolia ssp. retusa leaves for the treatment of diabetes mellitus.Keywords: Diabetes, Sida rhombifolia ssp. Retusa, hypoglycemic activity and hypolipidemic activity

CONTROLLED CLINICAL EVALUATION OF MAMAJJAK CHOORNA IN STHULA MADHUMEHA VIZ-A-VIZ TYPE 2 DIABETES MELLITUS

Sthula Madhumeha (viz-e-viz type 2Diabetes Mellitus) is the vital problem in present era. The change in lifestyle and food habit is the major concern of the problem. The available drug therapy concentrating on levels of blood sugar rather than symptoms of patients like excessive thirst, Nocturnal enuresis, burning sensation in hands, feet and many more. Ayurveda emphasized more on these symptoms. These symptoms affects the patients routine life and work capacity. On behalf of these symptoms the role of Mamajjak Choorna which is described by Acharya Priyavrat Sharma in his book Dravya guna Vidnyan Vol. 2 page 705 found to be more effective in comparison to modern oral hypoglycemic and well practiced drug Metformin. Total 40 patients of newly diagnosed of Diabetes Mellitus were taken and divided in two groups as Trial group 20 patients on Mamajjak Choorna 5 gm B.I.D. given for 12 weeks. Control Group 20 patients on tab. Metformin 500 mg B.I.D. given for 12 weeks. On consumption of Mamajjak Choorna for 12 weeks it was found that there is improvement in the symptoms Pipasati Pravrutti (74.27%), Nakta mutrata (83.33%), Hasta-padatala daha (82.5%) Pippalika Sancharvaat prachti (85.71%), Prabhuta Avila mutrata (77.5%), Swedatipravritti (82.5%) so far as consumption of Metformin is concern, it was found as follows Pipasati Pravrutti (64.71%), Nakta mutrata (72.94%), Hasta-padatala daha (51.28%), Pippalika Sancharvaat prachti (50%), Prabhuta Avila mutrata (71.88%), Swedatipravritti (51.16%). With P<0.05 (that highly significant results in Mamajjak Choorna group)

Radiation Response of Murine Embryonic Stem Cells

To understand the mechanisms of disturbed differentiation and development by radiation, murine CGR8 embryonic stem cells (mESCs) were exposed to ionizing radiation and differentiated by forming embryoid bodies (EBs). The colony forming ability test was applied for survival and the MTT test for viability determination after X-irradiation. Cell cycle progression was determined by flow cytometry of propidium iodide-stained cells, and DNA double strand break (DSB) induction and repair by γH2AX immunofluorescence. The radiosensitivity of mESCs was slightly higher compared to the murine osteoblast cell line OCT-1. The viability 72 h after X-irradiation decreased dose-dependently and was higher in the presence of leukemia inhibitory factor (LIF). Cells exposed to 2 or 7 Gy underwent a transient G2 arrest. X-irradiation induced γH2AX foci and they disappeared within 72 h. After 72 h of X-ray exposure, RNA was isolated and analyzed using genome-wide microarrays. The gene expression analysis revealed amongst others a regulation of developmental genes (Ada, Baz1a, Calcoco2, Htra1, Nefh, S100a6 and Rassf6), downregulation of genes involved in glycolysis and pyruvate metabolism whereas upregulation of genes related to the p53 signaling pathway. X-irradiated mESCs formed EBs and differentiated toward cardiomyocytes but their beating frequencies were lower compared to EBs from unirradiated cells. These results suggest that X-irradiation of mESCs deregulate genes related to the developmental process. The most significant biological processes found to be altered by X-irradiation in mESCs were the development of cardiovascular, nervous, circulatory and renal system. These results may explain the X-irradiation induced-embryonic lethality and malformations observed in animal studies

Person detection using an omnidirectional camera to shut off the UV-C light on disinfection robot for individuals' safety

One of the most significant global challenges faced during the COVID-19 pandemic was the need for efficient disinfection methods to prevent the spread of the virus. Ultraviolet-C (UV-C) disinfection robots became increasingly popular due to their ability to kill harmful bacteria and viruses using UV-C light. However, UV-C light can also be harmful to humans, so it is important to ensure that people are not exposed to it during disinfection operations. Existing object detection algorithms are limited to conventional images. These images can be stitched together to get a 360-degree view of surroundings but it can be computationally expensive and they may have different resolutions, lighting conditions, and noise levels. This thesis investigates the feasibility of using motion detection and YOLO (You Only Look Once) object detection to accurately detect individuals present within the disinfection environment using omnidirectional cameras. To achieve this goal, motion detection is implemented and analyzed as well as different YOLO models are trained on the 360 Indoor-dataset. These models are then evaluated on their ability to detect people in unseen environments. The results show that motion detection is not a feasible solution for our application because of its static background requirement, while YOLO demonstrates effectiveness with an omnidirectional camera achieving a mean Average Precision (mAP) of 75.34\%. The results also show that among all the YOLO models YOLOv5m achieved the best overall performance, with a precision of 0.80, a recall of 0.68, mAP of 0.73, and an inference speed of 8.2 ms. This indicates that the YOLOv5m model is a promising choice for person detection in real-time disinfection applications. In addition to the experimental results, this thesis also provides a discussion about how to use our trained YOLOv5m in the industry setting to avoid false detections. Overall, this thesis makes a notable contribution by evaluating motion detection for the disinfection robot and by demonstrating the feasibility of using YOLO with an omnidirectional camera through training on 360-degree images. Furthermore, the thesis identifies a more efficient version of YOLO for industrial deployment, with the potential for further development and improved performance

Effect of Geometrical Parameters on Sensitivity and Volume of Rectangular Beam Force Transducer

Load cells are transducers employed to measure force or weight. There is a wide variety of transducers;most of these transducers are based on strain gauges. In current research, optimization of strain gauge basedtransducer is carried out by maximizing sensitivity and minimizing the volume. A simple strain gauge based model of ‘Rectangular Beam Type’ load cell is considered for finite element method and finding an effect of critical dimensional parameters on sensitivity and volume. The experimental plan is constructed based on Response Surface Methodology (RSM). Next, multi-objective optimization is performed. Analysis of variance (ANOVA) is carried out to get contribution of each parameter on the performance characteristic

Role of Veterinarian in Rural Development of Khed Taluka of Maharashtra State

A study was carried out to determine the role of veterinarian in rural development in Khed taluka of Pune district. The survey was carried out in 19 villages of 4 subdivisions of Khed taluka by personnel interview and 210 farmers were screened. The study revealed that accessibility of veterinarian for 21.05 % (4) villages was below average, 73.68% (11) villages were average and 5.26% (1) villages were above average. The availability of veterinarian for 31.58 (6) villages was above average and rest 68.42% (13) were below average. The role in rural development of veterinarian was above average for 21.05% (4) villages, 36.84% (7) villages were average and rest 42.11% (8) villages were below average. The study also showed that 15.79% (3) villages were good, 42.12% (8) villages were average and 42.12% (8) villages were below average when total ranking of villages was done by block level veterinary service index. [Veterinary World 2008; 1(5.000): 133-135