Revising Knowledge Discovery for Object Representation with Spatio-Semantic Feature Integration

In large social networks, web objects become increasingly popular. Multimedia object classification and representation is a necessary step of multimedia information retrieval. Indexing and organizing these web objects for the purpose of convenient browsing and search of the objects, and to effectively reveal interesting patterns from the objects. For all these tasks, classifying the web objects into manipulable semantic categories is an essential procedure. One important issue for classification of objects is the representation of images. To perform supervised classification tasks, the knowledge is extracted from unlabeled objects through unsupervised learning. In order to represent the images in a more meaningful and effective way rather than using the basic Bag-of-words (BoW) model, a novel image representation model called Bag-of-visual phrases(BoP) is used. In this model visual words are obtained using hierarchical clustering and visual phrases are generated by vector classifier of visual words. To obtain the Spatio-semantic correlation knowledge the frequently co-occurring pairs are calculated from visual vocabulary. After the successful object representation, the tags, comments, and descriptions of web objects are separated by using most likelihood method. The spatial and semantic differentiation power of image features can be enhanced via this BoP model and likelihood method. DOI: 10.17762/ijritcc2321-8169.15065

Protective efficacy of Murraya koenigii aqueous extract against monosodium glutamate-induced hepatotoxicity in Wistar rats

The present work was designed to study the potential effect of antioxidant rich aqueous extract of Murraya koenigii (AE-MK) on monosodium glutamate-induced hepatotoxicity in Wistar rats. The study was conducted on thirty adult Wistar rats, classified into six groups. MSG (1000 mg/kg, p.o) was administered to induce hepatotoxicity. The MSG treated group showed significant (P ˂0.05) increase in % change in body weight, relative organ weight, SOD, MDA, cholesterol, bilirubin, triglycerides, LDL levels; and AST, ALT activity while significant (P <0.05) decrease in glutathione peroxidase, albumin, HDL level and ALP activity in liver tissue as compared to control group. AE-MK (200, 400 mg/kg) significantly (P <0.05) reversed all the above parameters as compared to MSG treated rats. Histopathological changes observed in MSG treated rat liver tissue were cytoplasmic vacuolation, sinusoidal congestion, and cellular aggregates around the portal area. These changes were reversed with AE-MK (200, 400 mg/kg). The total phenol content was found to be 62 µg of gallic acid equivalent /mg of extract and free radical scavenging activity by DPPH method was found to be 74.16%. The study suggests that antioxidant rich aqueous extract of M. koenigii has protective effect against MSG-induced hepatotoxicity

Review on Analysis of Seam Quality

The apparel quality largely depends on fabric quality and also on seam quality. Seam performance and appearance largely correlate with fabric characteristics, sewing-thread properties, selection of stitches and seams, and also with sewing conditions such as size of needle, sewing-thread tension, number of stitches per inch, and maintenance and operation of sewing machine. In good quality garments, functional requirements of the seam are very essential for apparel serviceability. The seam performance deteriorates the quality of garment by reducing seam strength and seam-slippage strength, seam puckering, and seam damage. Apparel durability and its esthetic performance are defined by seam quality. Seam performance is influenced by a selection of seam type with respect to stitch classes, selection of sewing threads irrespective to fabric characteristics, and different sewing process parameters

Non valvular atrial fibrillation stroke risk stratification by CHA2DS2-VASc score and short term outcomes

Background: Atrial fibrillation confers a high risk of stroke and is associated with significant mortality and morbidity. Many scoring systems for have been proposed stroke risk stratification in atrial fibrillation. Peripheral thromboembolism, heart failure and death. The main objective of the study was to estimate CHA2DS2VASc score in cases of non valvular atrial fibrillation, to asses short term outcome in AF (stroke, thromboembolism, heart failure and death and to find out association of CHA2DS2VASc score with outcomes.Methods: 64 cases (29 M, 35 F) of non valvular AF were included in this prospective observational study.CHA2DS2VASc score was calculated and cases were categorized into low (score 0), intermediate (score 1 ) and high risk (score 2 ) for development of stroke. Cases were clinically evaluated and investigated for type, etiology, complications and comorbidities.Results: CHA2DS2VASc score was determined in 64 cases of non valvular AF. In 3 cases (4.6%) it was zero indicating low risk for stroke, 8 cases (12.5%) had CHA2DS2VASc score as 1had intermediate risk, and 53 cases (82.8%) had score 2 or more indicating high stroke risk (p<0.01). 3 cases of non valvular atrial fibrillation (4.6%) presented with stroke and all of them had CHA2DS2VASc score>2. At the end of 3 months, total no. of cases with stroke was reported to be 5 (7.8 %). Stroke risk was significantly higher in cases of CHA2DS2VASc score>2 (p<0.01). Congestive heart failure was reported in 32 (50%) cases. Peripheral embolism was documented in 1 case (1.5%). Overall Mortality at the end of 3 months was reported to be 7 (10.9%) and cases with CHA2DS2VASc score ≥2 had 13% mortality. CHA2DS2VASc score ≥2 was significantly associated with mortality (p<0.01). All 3 Cases with CHA2DS2VASc score as zero were uncomplicated. 8 cases (12.5%) had score as 1 and, out of these 8 cases, CHF was reported in 2 cases (25%), while 6 (75%) were uncomplicated.CHA2DS2VASc score ≥2 was reported in 53 cases (82.3%). This group had complications in the form of CHF in 30 cases (56.6 %), thromboembolism in 1 (1.8%), and stroke in 5 (9.4%) cases. Cases of AF with CHA2DS2VASc score >2 demonstrated significantly high incidence for stroke as compared to those with score as zero or one (p<0.01).Conclusions: CHA2DS2VASc is a simple score to predict stroke risk in cases of non valvular atrial fibrillation and is easy to estimate. CHA2DS2VASc score ≥2; is associated with high incidence of stroke in cases of non valvular AF. CHA2DS2VASc score≥2 is associated with mortality as a short term adverse outcome in non valvular atrial fibrillation.

The effectiveness of a low-intensity problem-solving intervention for common adolescent mental health problems in New Delhi, India: protocol for a school-based, individually randomized controlled trial with an embedded stepped-wedge cluster randomized controlled recruitment trial

Background Conduct, anxiety and depressive disorders account for over 75% of the adolescent mental health burden globally. The current protocol will test a low-intensity problem-solving intervention for school-going adolescents with common mental health problems in India. The protocol also tests the effects of a classroom-based sensitization intervention on the demand for counselling services in an embedded recruitment trial. Methods We will conduct a two-arm individually randomized controlled trial in six Government-run secondary schools in New Delhi. The targeted sample is 240 adolescents in grades 9-12 with persistent, elevated mental health symptoms and associated impact. Participants will receive either a brief problem-solving intervention delivered over 3 weeks by lay counsellors (intervention), or enhanced usual care comprised of problem-solving booklets (control). Self-reported adolescent mental health symptoms and idiographic problems will be assessed at 6 weeks (co-primary outcomes) and again at 12 weeks post-randomization. In addition, adolescent-reported impact of mental health difficulties, perceived stress, mental wellbeing and clinical remission, as well as parent-reported adolescent mental health symptoms and impact scores, will be assessed at 6 and 12 weeks post-randomization. We will also complete a parallel process evaluation, including estimations of the costs of delivering the interventions. An embedded recruitment trial will apply a stepped-wedge, cluster (class)-randomized controlled design in 70 classes across the six schools. This will evaluate the added impact of a classroom-based sensitization intervention over school-level recruitment sensitization activities on the primary outcome of referral rate into the host trial (i.e. the proportion of adolescents referred as a function of the total sampling frame in each condition of the embedded recruitment trial). Other outcomes will be the proportion of referrals eligible to participate in the host trial, proportion of self-generated referrals, and severity and pattern of symptoms among referred adolescents in each condition. Power calculations were undertaken separately for each trial. A detailed statistical analysis plan will be developed separately for each trial prior to unblinding. Discussion Both trials were initiated on 20 August 2018. A single research protocol for both trials offers a resource-efficient methodology for testing the effectiveness of linked procedures to enhance uptake and outcomes of a school-based psychological intervention for common adolescent mental health problems

Protective efficacy of Murraya koenigii aqueous extract against monosodium glutamate-induced hepatotoxicity in Wistar rats

188-196The present work was designed to study the potential effect of antioxidant rich aqueous extract of Murraya koenigii (AE-MK) on monosodium glutamate-induced hepatotoxicity in Wistar rats. The study was conducted on thirty adult Wistar rats, classified into six groups. MSG (1000 mg/kg, p.o) was administered to induce hepatotoxicity. The MSG treated group showed significant (P ˂0.05) increase in % change in body weight, relative organ weight, SOD, MDA, cholesterol, bilirubin, triglycerides, LDL levels; and AST, ALT activity while significant (P <0.05) decrease in glutathione peroxidase, albumin, HDL level and ALP activity in liver tissue as compared to control group. AE-MK (200, 400 mg/kg) significantly (P <0.05) reversed all the above parameters as compared to MSG treated rats. Histopathological changes observed in MSG treated rat liver tissue were cytoplasmic vacuolation, sinusoidal congestion, and cellular aggregates around the portal area. These changes were reversed with AE-MK (200, 400 mg/kg). The total phenol content was found to be 62 μg of gallic acid equivalent /mg of extract and free radical scavenging activity by DPPH method was found to be 74.16%. The study suggests that antioxidant rich aqueous extract of M. koenigii has protective effect against MSG-induced hepatotoxicity

Synthesis of D-fructose-derived spirocyclic 2-substituted-2-oxazoline ribosides

The TMSOTf-mediated synthesis of β-configured spirocyclic 2-substituted-2-oxazoline ribosides was achieved using a “Ritter-like” reaction in toluene through nucleophilic addition of electron-rich nitriles to the oxacarbenium ion intermediate of 1,2;3,4-di-O-isopropylidene-β-D-psicofuranose derivatives with concomitant intramolecular trapping of the C2 hydroxymethyl group on the electrophilic nitrilium carbon. These carbohydrate-derived spirooxazolines are stable and were obtained in good yield with high stereoselectivity due to the conformational rigidity imparted by the 3,4-isopropylidene group

Evaluation of different genomic regions of rotavirus B and rotavirus C for development of real-time RT‒PCR assays

Abstract Background The causative agents of diarrhea, rotavirus B (RVB) and rotavirus C (RVC) are common in adults and patients of all age groups, respectively. Due to the Rotavirus A (RVA) vaccination program, a significant decrease in the number of gastroenteritis cases has been observed globally. The replacement of RVA infections with RVB, RVC, or other related serogroups is suspected due to the possibility of reducing natural selective constraints due to RVA infections. The data available on RVB and RVC incidence are scant due to the lack of cheap and rapid commercial diagnostic assays and the focus on RVA infections. The present study aimed to develop real-time RT‒PCR assays using the data from all genomic RNA segments of human RVB and RVC strains available in the Gene Bank. Results Among the 11 gene segments, NSP3 and NSP5 of RVB and the VP6 gene of RVC were found to be suitable for real-time RT‒PCR (qRT‒PCR) assays. Fecal specimens collected from diarrheal patients were tested simultaneously for the presence of RVB (n = 192) and RVC (n = 188) using the respective conventional RT‒PCR and newly developed qRT‒PCR assays. All RVB- and RVC-positive specimens were reactive in their respective qRT‒PCR assays and had Ct values ranging between 23.69 and 41.97 and 11.49 and 36.05, respectively. All known positive and negative specimens for other viral agents were nonreactive, and comparative analysis showed 100% concordance with conventional RT‒PCR assays. Conclusions The suitability of the NSP5 gene of RVB and the VP6 gene of RVC was verified via qRT‒PCR assays, which showed 100% sensitivity and specificity. The rapid qRT‒PCR assays developed will be useful diagnostic tools, especially during diarrheal outbreaks for testing non-RVA rotaviral agents and reducing the unnecessary use of antibiotics