Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding

The nuclear factor E2-related factor 2 (Nrf2)–Kelch-like ECH-associated protein 1 (Keap1) pathway upregulates antioxidant and biotransformation enzyme expression to counter cellular oxidative stress. The contributions of Nrf2 to other cellular functions, such as lipid homeostasis, are emerging. This study was conducted to determine how enhanced Nrf2 activity influences the progression of metabolic syndrome with long-term high-fat diet (HFD) feeding. C57BL/6 and Keap1-knockdown (Keap1-KD) mice, which exhibit enhanced Nrf2 activity, were fed a HFD for 24 weeks. Keap1-KD mice had higher body weight and white adipose tissue mass compared to C57BL/6 mice on HFD, along with increased inflammation and lipogenic gene expression. HFD feeding increased hepatic steatosis and inflammation to a greater extent in Keap1-KD mice compared to C57BL/6 mice, which was associated with increased liver Cd36, fatty acid-binding protein 4, and monocyte chemoattractant protein 1 mRNA expression, as well as increased acetyl-CoA carboxylase 1 and stearoyl-CoA desaturase-1 protein expression. The HFD altered short-term glucose homeostasis to a greater degree in Keap-KD mice compared to C57BL/6 mice, which was accompanied by downregulation of insulin receptor substrate 1 mRNA expression in skeletal muscle. Together, the results indicate that Keap1 knockdown, on treatment with HFD, increases certain markers of metabolic syndrome

Vibrations of laminated beams

Governing equations in the form of simultaneous ordinary differential equations have been derived for natural vibration analysis of isotropic laminated beams. This formulation includes significant secondary effects such as transverse shear and rotatory inetia. Through a numerical example, the influence of these secondary effects has been studied

Prediction Based Lossless Compression Scheme For Bayer Colour Filter Array Images Using Different Encoding And Decoding Techniques

This paper presents an experimental evaluation of the effectiveness of various techniques for lossless compression of CFA images. A colour image requires at least three colour samples at each pixel location. A digital camera would need three separate sensors to completely measure the image. In a three chip colour camera, the light entering the camera is split and projected onto each spectral sensor. Each sensor requires its proper driving electronics, and the sensors have to be registered precisely. These additional requirements add a large expense to the system. Thus most commercial digital cameras use colour filterarrays to sample red, green, and blue colours according to a specificpattern. At the location of each pixel only one colour sample istaken and the values of the other colours must be interpolated usingneighbouring samples

Secure Framework in Data Processing for Mobile Cloud Computing

Abstract-Generally Mobile Cloud storage enables users to remotely store their data and enjoy the on-demand high quality cloud applications without the burden of local hardware and software management. Though the benefits are clear, such a service is also relinquishing users 'physical possession of their outsourced data, which inevitably poses new security risks towards the correctness of the data in cloud. In order to address this new problem and further achieve a secure and dependable cloud storage service, we propose in this paper a new secure framework. In addition to providing traditional computation services, mobile cloud also enhances the operation of traditional ad hoc network by treating mobile devices as service nodes, e.g., sensing services. The mobile services or sensed information, such as location coordinates, health related information, should be processed and stored in a secure fashion to protect user's privacy in the cloud. In this paper, we present a new mobile cloud data processing framework through trust management and private data isolation. Finally, an implementation pilot for improving teenagers' driving safety, which is called FocusDrive, is presented to demonstrate the solution

Synthesis, characterization and antimicrobial activities of metal complexes of 2-formyl thymol oxime

665-669 Metal to ligand (1: 2) complexes with molecular formula [M(HL)2]n [HL = anionic form of 2-formyl thymol oxime, M = metal (II) ion] of 2-formyl thymol oxime (H2L) and its manganese, iron, cobalt, nickel, copper and zinc complexes have been prepared and characterized by elemental analysis, magnetic measurements, molar conductivity, IR and UV-Visible spectroscopy. Complexes were tested for antimicrobial activities against Escherichia coli, Pseudomonas putida, P. fluorescense and Bradyrhizobium japonicum and fungal cultures Aspergillus niger, A. flavus, Fusarium oxysporum, and Alternaria alternata. </smarttagtype