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THE EFFECT OF PENTOXIFYLLINE ON THE PERFORMANCE THE COAGULATION SYSTEM IN PATIENTS WITH THORACOABDOMINAL INJURIES

Purpose: to study the effect of pentoxifylline on coagulation system in trauma patients. Materials and methods: conducted a retrospective analysis of 81 medical card of the inpatient with thoracoabdominal trauma. In 26 patients the treatment regimen was included pentoxifylline, 55 patients the drug is not administered. All patients were assessed changes in indicators of the coagulation system. Results: the levels of platelets and APTT in the dynamics decreased, and fibrinogen and PTT increased by the fifth day of treatment. More pronounced these changes were in the group of patients that pentoxifylline was not appointed. The hemoglobin level was more stable in those patients who were administered pentoxifylline. Summary: the inclusion of pentoxifylline in the treatment of patients with thoracoabdominal injuries do not lead to violations of the blood coagulation system

СОРБЦИЯ РЕНИЯ И ВАНАДИЯ ИЗ МИНЕРАЛИЗОВАННЫХ РАСТВОРОВ ВОЛОКНИСТЫМИ ИОНИТАМИ

Sorption of rhenium (VII) and vanadium (V) with FIBAN series fibrous ionites out of mineralized sulfuric-chloride solutions has been studied. Equilibrium, kinetic, and dynamic characteristics of rhenium and vanadium sorption with AK-22 grade FIBAN ionite that contains the following functional groups: =NH, –NH2, –СOOH, and ≡N are obtained. The maximum capacity of this ionite for vanadium (V) is found to be observed at pH = 4 value. Rhenium and vanadium sorption isotherms are linear and described by Henry’s equations with constants KH = 113±2 ml/g (R2 = 0,995) and 674±6 ml/g (R2 = 0,999) respectively. Integral kinetic curves of sorption are obtained under the conditions of limited solution volume. The effective diffusion coefficients of rhenium and vanadium (9,0·10–13 and 7,5·10–15 m2/s respectively) are calculated with taking the half-transformation time into account. The feasibility of rhenium and vanadium separation under the dynamic conditions is shown.Изучена сорбция рения (VII) и ванадия (V) волокнистыми ионитами серии ФИБАН из минерализованных сульфатно-хлоридных растворов. Получены равновесные, кинетические и динамические характеристики сорбции Re и V ионитом ФИБАН марки АК-22, содержащим следующие функциональные группы: =NH, –NH2, –СOOH и ≡N. Установлено, что максимальная емкость этого реагента по ванадию (V) наблюдается при значении рН = 4. Изотермы сорбции Re и V линейны и описываются уравнением Генри с константами Kг = 1,36±0,30 мл/г (R2 = 0,995) и 674±21 мл/г (R2 = 0,999) соответственно. В условиях ограниченного объема раствора получены интегральные кинетические кривые сорбции и с учетом времени полупревращения рассчитаны эффективные коэффициенты диффузии Re и V, составившие 9,0·10–13 и 7,5·10–15 м2/с соответственно. Показана возможность разделения этих металлов в динамических условиях

Reproducibility of cytological diagnoses in evaluating liquid cervical smears and immunocytochemical co-expression of p16/Ki-67 using manual and automatic methods

Aim. To assess the reproducibility of cytological diagnoses in evaluating liquid cervical smears and immunocytochemical co-expression of p16/Ki-67 using manual and automatic methods. Materials and methods. Cytological smears prepared using the liquid cytology method on the Becton Dickinson device (SurePath technology) were studied. An immunocytochemical study was carried out using a Ventana BenchMark Ultra automatic immunostainer with a commercial CINtec kit (determination of p16/Ki-67 co-expression). In total, 100 cytological slides (50 pairs of Pap-smears and immunocytochemical slides) were studied. The diagnostic kit was reviewed by five cytologists independently, and the cytologic slides were evaluated using four categories according to the Bethesda system (2014) and according to the categories of normal/abnormal. The co-expression of p16/Ki-67 was assessed per the manufacturer's recommendations (Roche) using the manual method (light microscope) and the automatic Vision Cyto Pap ICC system. Statistical processing of the results was performed using the SPSS software package version 26.0.0.0 with the calculation of the reproducibility indices of Cohen's kappa and Fleiss' kappa. Results. When assessing the reproducibility of four categories of cytological diagnoses according to the Bethesda system (2014), Cohen's kappa was 0.0480.265. The overall Fleiss' kappa between all cytologists was 0.103. When only two categories (normal/abnormal) were used, the reproducibility ranged from 0.058 to 0.377. When assessing the co-expression of p16 and Ki-67, Cohen's kappa reproducibility was from 0.196 to 0.574, while the overall Fleiss' kappa was 0.407. When comparing the evaluation results of each of the cytologists with the neural network, Cohen's kappa reproducibility ranged from 0.103 to 0.436. Conclusion. The reproducibility of cytological diagnoses according to the Bethesda system (2014) and two categories (normal/abnormal) based on the Pap smear study was low. Such results are primarily due to a large number of abnormal smears in the study. The immunocytochemical method has diagnosis reproducibility three times higher, indicating the need to measure the co-expression of p16 and Ki-67 to increase the sensitivity and specificity of the cytological method. Similar reproducibility when comparing the manual and automatic evaluation of the "double label" suggests that the neural network algorithm can currently help in decision support rather than replace the cytologist at the diagnostic stage

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