Особенности активационных процессов коры головного мозга при олигоменорее у подростков

The article presents the data on the epidemiology of menstrual cycle disorders of Krasnoyarsk teenagers. The increase in the frequency of oligomenorrhea, indicating worsening of functional disorders of the reproductive system, has been revealed. Due to the possible relation between oligomenorrhea development and disruption of activation processes of cerebral cortex, the dynamic measurement of omega-potential of cerebral hemispheres was conducted. The study was carried out in a group of female patients before the hormone therapy and after its completion. It was revealed that the basic values of the omega-potential of the girls with oligomenorrhea are characterized with its increase, indicating a high level of mental stress. The results have revealed the dependence of normalization of the activation processes of the cerebral cortex and the option of hormonal correction of oligomenorrhea.В статье приводятся данные по эпидемиологии нарушения менструального цикла подростков г. Красноярска. Выявлено увеличение частоты олигоменореи, что свидетельствует об усугублении функциональных расстройств репродуктивной системы. В связи с возможной зависимостью развития олигоменореи и нарушением активационных процессов коры головного мозга проведено динамическое измерение омега-потенциала полушарий мозга. Исследование проведено в группе пациенток до начала гормональной терапии и после ее окончания. Выявлено, что базовые значения омега-потенциала у девушек с олигоменореей характеризуются его повышением, что свидетельствует о высоком уровне психического напряжения. Выявлена зависимость нормализации активационных процессов коры головного мозга и варианта гормональной коррекции олигоменореи

ROLE OF INFORMAL ASSESSMENT IN IMPROVING STUDENTS` REFLECTION

Purpose. The article is devoted to various methods of informal assessment and their potential for developing students’ reflective skills. The authors analyze different theories and approaches to reflective learning in order to design tools for enhancing students’ reflective abilities. Methodology. The data obtained through the research are evaluated and interpreted on the basis of the descriptive approach. The authors also adopt the reflective-activity approach for designing a set of reflective statements. Results. The authors study the main features of informal assessment, compare and contrast them with the forms of formal assessment pointing out that new approaches to assessment such as Learning Oriented Assessment (LOA) should be adopted in order to promote learning, motivate students and encourage their autonomy. Special attention is given to feedback as an LOA component, which correlates with the concept of reflective learning. The authors analyze various theories of reflective learning and design a system of reflective statement, which could be used as a means of practical development of students’ reflective abilities. Practical implications. The results of the research can be applied in teaching practice of various disciplines at higher educational establishments

Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling

Background: Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG), which signals through Na/K‐ATPase. Rapamycin is an inhibitor of the serine/threonine kinase mammalian target of rapamycin (mTOR) implicated in the progression of many different forms of renal disease. Given that Na/K‐ATPase signaling is known to stimulate the mTOR system, we speculated that the ameliorative effects of rapamycin might influence this pathway. Methods and Results: Biosynthesis of MBG by cultured human JEG‐3 cells is initiated by CYP27A1, which is also a target for rapamycin. It was demonstrated that 1 μmol/L of rapamycin inhibited production of MBG in human JEG‐2 cells. Male Sprague‐Dawley rats were subjected to either partial nephrectomy (PNx), infusion of MBG, and/or infusion of rapamycin through osmotic minipumps. PNx animals showed marked increase in plasma MBG levels (1025±60 vs 377±53 pmol/L; PPP Conclusions: Rapamycin treatment in combination with MBG infusion significantly attenuated cardiac fibrosis. Our results suggest that rapamycin may have a dual effect on cardiac fibrosis through (1) mTOR inhibition and (2) inhibiting MBG‐mediated profibrotic signaling and provide support for beneficial effect of a novel therapy for uremic cardiomyopathy

Analysis of the socio-economic indicators of the Irkutsk region, Buryatia, and the Far East in 2016-2017: investments and prospects

Socio-economic indicators of the Irkutsk region, Buryatia and the Far East, dynamics of their development in 2016-2017, and problems and prospects are considered in this paper. Today, the priority for the regions of Siberia and the Far East, which possess unique natural resources and a vast territory, is the complex task of increasing the living standard of the population and launching a new economic strategy. The Irkutsk region is one of the largest industrial regions of Russia. The city of Irkutsk was formed as an administrative, commercial and cultural-educational center. Currently, it is home to more than 50% of the urban population of the Irkutsk region. Some enterprises of the city have a machine-building profile. The production of food (more than 45% of the total volume), the construction material, and wood processing also play an important role. External migration has a significant impact on the demographic situation in the region. Most of the migration processes with the crossing of the boundaries of the region take place within Russia. According to statistical data, external migration can be divided as the three main flows of foreign citizens entering the territory of the Irkutsk region: the Central Asian direction (Uzbekistan, Tajikistan, Kyrgyzstan, and Kazakhstan 44.3%); the East Asian direction (China, Mongolia, DPRK, Japan, and Vietnam 30.8%); and the Western direction (Germany, France, and Poland). It should be also noted that 13.9% of all migrants are migrants from Ukraine, Armenia, Belarus, and Moldova, these are mainly young people of working age. The Baikal region is famous in Russia for its natural landscapes: there are more than 1,500 objects of excursion and cognitive significance (natural, architectural, cultural and historical monuments) in the region. The region has a great industrial potential that is of national importance. Several basic complexes and industries compile a modern industrial structure. There are opportunities for further development of the industrial production in the oil and gas industries, diamond mining industry, the production of composite materials, fibers and mineral fertilizers. On the Far East, priority is given today to the raw material economy and the related infrastructure facilities, including the modernization of the Trans-Siberian Railway and the Baikal-Amur Mainline

The optimal decision of insulation in cladding structures for energy efficient buildings

Execution of thermal insulation for enclosing structures of residential properties is a sophisticated part of the thermal protection. The choice of insulation materials for external walls is one of the main ways to increase the performance of heat insulation. This article contains thermo-technical calculations of two enclosing structures due to conditions of Saint-Petersburg. According to the results, the thickness of the insulating layer and a total wall thickness of the exterior walls composed of concrete, insulation and sand-cement rendering are smaller than the same characteristics of wall construction of hollow tile, insulation and sand-cement rendering

The optimal decision of insulation in cladding structures for energy efficient buildings

Execution of thermal insulation for enclosing structures of residential properties is a sophisticated part of the thermal protection. The choice of insulation materials for external walls is one of the main ways to increase the performance of heat insulation. This article contains thermo-technical calculations of two enclosing structures due to conditions of Saint-Petersburg. According to the results, the thickness of the insulating layer and a total wall thickness of the exterior walls composed of concrete, insulation and sand-cement rendering are smaller than the same characteristics of wall construction of hollow tile, insulation and sand-cement rendering

Higher Education in Post-truth, postmodernism and the problem of moral devaluation

Of the goal of this study is to Educate the abstract concept as : Post-truth and Post modernism.  Post-truth as a social phenomenon has put scientific discourse into polemic discussions in connection with an acute public request for the restoration of the Truth. Postmodernism, the previous era that gave rise to the problems of moral devaluation, is regarded as a cynical environment that produced these problems. Postmodernism has softened up the ground for radical openness of the public to the requests for the Truth, which can no longer be ignored in the last decade. The research considers modern sources of the formation of socio-ethical phenomena, which are the main life criteria in developed countries. Politics, media and culture are the core of any state and the entire global space. It is in the time of globalization, interstate interdependence, information wars and global warming that these aspects have attracted increased public interest. We provide a comparative argumentation of postmodernism and post-truth proving that the request for the Truth has become a new reality factor due to the mass public demand. The morality and ethics of the Truth have regained their classical forms and escaped from mass manipulation. Consequently, the issues of morality and values have become relevant. Ideologically, the world community demonstrates a genuine desire to restore the socio-ethical mission of the Truth. This statement is proved in our research

Assessment of the economic consequences of investment decisions companies

У статті розглянуті особливості здійснення інвестиційних рішень з урахуванням існуючих можливостей залучення різних джерел їх фінансування. Запропонований методичний підхід до оцінки впливу структури капіталу інвестиційного проекту суб’єкта господарювання на показники фінансово-економічного стану підприємства в цілому. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/23875В статье рассмотрены особенности осуществления инвестиционных решений с учетом существующих возможностей привлечения различных источников их финансирования. Предложен методический подход к оценке влияния структуры капитала инвестиционного проекта субъекта хозяйствования на показатели финансово-экономического состояния предприятия в целом. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/23875In the article the features of investment decisions taking into account the existing capacity to attract a variety of sources of funding. We propose a methodological approach to assessing the impact of the capital structure of the investment project entity in financial and economic condition of the enterprise as a whole. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2387