351 research outputs found
Numerical simulation on directional solidification of Al-Ni-Co alloy based on FEM
The ratio, of the temperature gradient at the solidification front to the solidification rate of solid-liquid interface, plays a large part in columnar grain growth. The transient temperature fields of directional solidification of Al-Ni-Co alloy were studied by employing a finite element method. The temperature gradient at the solidification front and the solidification rate were analyzed for molten steels pouring at different temperatures. The results show that with different initial pouring temperatures, the individual ratio of the temperature gradient at solidification front to the solidification rate soars up in the initial stage of solidification, then varies within 2,000-6,000 ℃·s·cm-2, and finally goes down rapidly and even tend to be closed to each other when the solidification thickness reaches 5-6 cm. The simulation result is consistent with the practical production which can provide an available reference for process optimization of directional solidified Al-Ni-Co alloy
Molecular basis for heat desensitization of TRPV1 ion channels.
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. We further show that knock-in mice expressing pV1 sensed heat normally but suffered scald damages in a hot environment. Our findings suggest that Dh evolved late during evolution as a protective mechanism and a delicate balance between Ah and Dh is crucial for mammals to sense and respond to noxious heat
Perfect codes in 2-valent Cayley digraphs on abelian groups
For a digraph , a subset of is a perfect code if
is a dominating set such that every vertex of is dominated by exactly
one vertex in . In this paper, we classify strongly connected 2-valent
Cayley digraphs on abelian groups admitting a perfect code, and determine
completely all perfect codes of such digraphs
Theoretical study of single-molecule spectroscopy and vibrational spectroscopy in condensed phases
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Includes bibliographical references (p. 267-279).In this thesis, theoretical models and computer simulations are employed to study several problems of single-molecule spectroscopy and vibrational spectroscopy in condensed phases. The first part of the thesis concentrates on studying dynamic disorders probed by single molecule fluorescence spectroscopy. Event statistics and correlations of single-molecule fluorescence sequences of modulated reactions are evaluated for multi-channel model, diffusion-controlled reaction model, and stochastic rate model. Several event-related measurements, such as the on-time correlation and the two-event number density, are proposed to map out the memory function, which characterizes the correlation in the conformational fluctuations. A semiflexible Gaussian chain model is used to determine the statistics and correlations of single-molecule fluorescence resonant energy transfer (FRET) experiments on biological polymers. The distribution functions of the fluorescence lifetime and the FRET efficiency provide direct measures of the chain stiffness and their correlation functions probe the intra-chain dynamics at the single-molecule level. The fluorescence lifetime distribution is decomposed into high order memory functions that can be measured in single- molecule experiments. The scaling of the average fluorescence lifetime on the contour length is predicted with the semi-flexible Gaussian chain model and agrees favorably with recent experiments and computer simulations.(cont.) To interpret the fluorescence measurements of the mechanical properties of double-stranded DNA, a worm-like chain model is used as a first-principle model to study double-stranded DNA under hydrodynamic flows. The second part of the thesis concentrates on nonperturbative vibrational energy relaxation (VER) effects of vibrational line shapes. In general, nonperturbative and non-Markovian VER effects are demonstrated more strongly on nonlinear vibrational line shapes than on linear absorption.by Shilong Yang.Ph.D
An Early Evaluation of GPT-4V(ision)
In this paper, we evaluate different abilities of GPT-4V including visual
understanding, language understanding, visual puzzle solving, and understanding
of other modalities such as depth, thermal, video, and audio. To estimate
GPT-4V's performance, we manually construct 656 test instances and carefully
evaluate the results of GPT-4V. The highlights of our findings are as follows:
(1) GPT-4V exhibits impressive performance on English visual-centric benchmarks
but fails to recognize simple Chinese texts in the images; (2) GPT-4V shows
inconsistent refusal behavior when answering questions related to sensitive
traits such as gender, race, and age; (3) GPT-4V obtains worse results than
GPT-4 (API) on language understanding tasks including general language
understanding benchmarks and visual commonsense knowledge evaluation
benchmarks; (4) Few-shot prompting can improve GPT-4V's performance on both
visual understanding and language understanding; (5) GPT-4V struggles to find
the nuances between two similar images and solve the easy math picture puzzles;
(6) GPT-4V shows non-trivial performance on the tasks of similar modalities to
image, such as video and thermal. Our experimental results reveal the ability
and limitations of GPT-4V and we hope our paper can provide some insights into
the application and research of GPT-4V.Comment: Technical Report. Data are available at
https://github.com/albertwy/GPT-4V-Evaluatio
Neural Interactive Keypoint Detection
This work proposes an end-to-end neural interactive keypoint detection
framework named Click-Pose, which can significantly reduce more than 10 times
labeling costs of 2D keypoint annotation compared with manual-only annotation.
Click-Pose explores how user feedback can cooperate with a neural keypoint
detector to correct the predicted keypoints in an interactive way for a faster
and more effective annotation process. Specifically, we design the pose error
modeling strategy that inputs the ground truth pose combined with four typical
pose errors into the decoder and trains the model to reconstruct the correct
poses, which enhances the self-correction ability of the model. Then, we attach
an interactive human-feedback loop that allows receiving users' clicks to
correct one or several predicted keypoints and iteratively utilizes the decoder
to update all other keypoints with a minimum number of clicks (NoC) for
efficient annotation. We validate Click-Pose in in-domain, out-of-domain
scenes, and a new task of keypoint adaptation. For annotation, Click-Pose only
needs 1.97 and 6.45 NoC@95 (at precision 95%) on COCO and Human-Art, reducing
31.4% and 36.3% efforts than the SOTA model (ViTPose) with manual correction,
respectively. Besides, without user clicks, Click-Pose surpasses the previous
end-to-end model by 1.4 AP on COCO and 3.0 AP on Human-Art. The code is
available at https://github.com/IDEA-Research/Click-Pose.Comment: Accepted to ICCV 202
Modeling and 3D Simulation of the Mould Compression and Resin Flow for Force-Controlled Compression Resin Transfer Moulding
Since the existence of the complicated coupling between mould compression and resin flow, the full 3D simulation of the filling process in force-controlled compression resin transfer moulding (CRTM) has not been realized, especially when the resin flow front is irregular on the thickness direction during thick part moulding. In this paper, the coupled resin flow and mould compression behaviors are investigated firstly, a equivalent spring method is proposed to describe the preform compaction. The lubrication effect is taken into account, so the mould compression speed can be determined when the resin flow front is irregular on the thickness direction. Then the Volume of Fluid (VOF) two-phase model is established to express the resin-air flow in narrow gap and preform simultaneously, in which the narrow gap is considered as 3D area without flow resistance. Finally, the 3D numerical method for solving the above mathematical models is developed. In this method, the changing of the mould cavity is simulated by moving mesh technology, and the master-slave element method is used to simulate the resin squeezing from the infiltrated preform. Comparisons with analysis results are provided to prove the correctness of the above method, and two 3D examples are given to demonstrate the simulating capability
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