172 research outputs found
Escape from a metastable well under a time-ramped force
Thermally activated escape of an over-damped particle from a metastable well
under the action of a time-ramped force is studied. We express the mean first
passage time (MFPT) as the solution to a partial differential equation, which
we solve numerically for a model case. We discuss two approximations of the
MFPT, one of which works remarkably well over a wide range of loading rates,
while the second is easy to calculate and can provide a valuable first
estimate.Comment: 9 pages, including 2 figure
The Role of Bilayer Tilt Difference in Equilibrium Membrane Shapes
Lipid bilayer membranes below their main transition have two tilt order
parameters, corresponding to the two monolayers. These two tilts may be
strongly coupled to membrane shape but only weakly coupled to each other. We
discuss some implications of this observation for rippled and saddle phases,
bilayer tubules, and bicontinuous phases. Tilt difference introduces a length
scale into the elastic theory of tilted fluid membranes. It can drive an
instability of the flat phase; it also provides a simple mechanism for the
spontaneous breaking of inversion symmetry seen in some recent experiments.Comment: Latex file; .ps available at
http://dept.physics.upenn.edu/~nelson/saddle.p
Rupture of multiple parallel molecular bonds under dynamic loading
Biological adhesion often involves several pairs of specific receptor-ligand
molecules. Using rate equations, we study theoretically the rupture of such
multiple parallel bonds under dynamic loading assisted by thermal activation.
For a simple generic type of cooperativity, both the rupture time and force
exhibit several different scaling regimes. The dependence of the rupture force
on the number of bonds is predicted to be either linear, like a square root or
logarithmic.Comment: 8 pages, 2 figure
Polyhedral vesicles
Polyhedral vesicles with a large bending modulus of the membrane such as the
gel phase lipid membrane were studied using a Brownian dynamics simulation. The
vesicles exhibit various polyhedral morphologies such as tetrahedron and cube
shapes. We clarified two types of line defects on the edges of the polyhedrons:
cracks of both monolayers at the spontaneous curvature of monolayer , and a crack of the inner monolayer at . Around the
latter defect, the inner monolayer curves positively. Our results suggested
that the polyhedral morphology is controlled by .Comment: 4 pages, 5 figure
Haemoglobulin catabolism: the role of ferrihaems in studies of the degradation pathway (Short Communication)
Is There Pain in Champagne? Semantic Involvement of Words within Words during Sense-making
Multi-Particle Collision Dynamics -- a Particle-Based Mesoscale Simulation Approach to the Hydrodynamics of Complex Fluids
In this review, we describe and analyze a mesoscale simulation method for
fluid flow, which was introduced by Malevanets and Kapral in 1999, and is now
called multi-particle collision dynamics (MPC) or stochastic rotation dynamics
(SRD). The method consists of alternating streaming and collision steps in an
ensemble of point particles. The multi-particle collisions are performed by
grouping particles in collision cells, and mass, momentum, and energy are
locally conserved. This simulation technique captures both full hydrodynamic
interactions and thermal fluctuations. The first part of the review begins with
a description of several widely used MPC algorithms and then discusses
important features of the original SRD algorithm and frequently used
variations. Two complementary approaches for deriving the hydrodynamic
equations and evaluating the transport coefficients are reviewed. It is then
shown how MPC algorithms can be generalized to model non-ideal fluids, and
binary mixtures with a consolute point. The importance of angular-momentum
conservation for systems like phase-separated liquids with different
viscosities is discussed. The second part of the review describes a number of
recent applications of MPC algorithms to study colloid and polymer dynamics,
the behavior of vesicles and cells in hydrodynamic flows, and the dynamics of
viscoelastic fluids
Small temporal asynchronies between the two eyes in binocular reading: Crosslinguistic data and the implications for ocular prevalence
Multipolar Reactive DPD: A Novel Tool for Spatially Resolved Systems Biology
This article reports about a novel extension of dissipative particle dynamics
(DPD) that allows the study of the collective dynamics of complex chemical and
structural systems in a spatially resolved manner with a combinatorially
complex variety of different system constituents. We show that introducing
multipolar interactions between particles leads to extended membrane structures
emerging in a self-organized manner and exhibiting both the necessary
mechanical stability for transport and fluidity so as to provide a
two-dimensional self-organizing dynamic reaction environment for kinetic
studies in the context of cell biology. We further show that the emergent
dynamics of extended membrane bound objects is in accordance with scaling laws
imposed by physics.Comment: submitted to CMSB 0
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