The Lyman-alpha Forest Power Spectrum from the Sloan Digital Sky Survey

We measure the power spectrum, P_F(k,z), of the transmitted flux in the Ly-alpha forest using 3035 high redshift quasar spectra from the Sloan Digital Sky Survey. This sample is almost two orders of magnitude larger than any previously available data set, yielding statistical errors of ~0.6% and ~0.005 on, respectively, the overall amplitude and logarithmic slope of P_F(k,z). This unprecedented statistical power requires a correspondingly careful analysis of the data and of possible systematic contaminations in it. For this purpose we reanalyze the raw spectra to make use of information not preserved by the standard pipeline. We investigate the details of the noise in the data, resolution of the spectrograph, sky subtraction, quasar continuum, and metal absorption. We find that background sources such as metals contribute significantly to the total power and have to be subtracted properly. We also find clear evidence for SiIII correlations with the Ly-alpha forest and suggest a simple model to account for this contribution to the power. While it is likely that our newly developed analysis technique does not eliminate all systematic errors in the P_F(k,z) measurement below the level of the statistical errors, our tests indicate that any residual systematics in the analysis are unlikely to affect the inference of cosmological parameters from P_F(k,z). These results should provide an essential ingredient for all future attempts to constrain modeling of structure formation, cosmological parameters, and theories for the origin of primordial fluctuations.Comment: 92 pages, 45 of them figures, submitted to ApJ, data available at http://feynman.princeton.edu/~pmcdonal/LyaF/sdss.htm

The Linear Theory Power Spectrum from the Lyman-alpha Forest in the Sloan Digital Sky Survey

We analyze the SDSS Ly-alpha forest P_F(k,z) measurement to determine the linear theory power spectrum. Our analysis is based on fully hydrodynamic simulations, extended using hydro-PM simulations. We account for the effect of absorbers with damping wings, which leads to an increase in the slope of the linear power spectrum. We break the degeneracy between the mean level of absorption and the linear power spectrum without significant use of external constraints. We infer linear theory power spectrum amplitude Delta^2_L(k_p=0.009s/km,z_p=3.0)=0.452_{-0.057-0.116}^{+0.069+0.141} and slope n_eff=-2.321_{-0.047-0.102}^{+0.055+0.131} (possible systematic errors are included through nuisance parameters in the fit - a factor >~5 smaller errors would be obtained on both parameters if we ignored modeling uncertainties). The errors are correlated and not perfectly Gaussian, so we provide a chi^2 table to accurately describe the results. The result corresponds to sigma_8=0.85, n=0.94, for a LCDM model with Omega_m=0.3, Omega_b=0.04, and h=0.7, but is most useful in a combined fit with the CMB. The inferred curvature of the linear power spectrum and the evolution of its amplitude and slope with redshift are consistent with expectations for LCDM models, with the evolution of the slope, in particular, being tightly constrained. We use this information to constrain systematic contamination, e.g., fluctuations in the UV background. This paper should serve as a starting point for more work to refine the analysis, including technical improvements such as increasing the size and number of the hydrodynamic simulations, and improvements in the treatment of the various forms of feedback from galaxies and quasars.Comment: Improved presentation, including fit results for (z). Simple code to produce LyaF chi^2 given linear power spectrum available at: http://www.cita.utoronto.ca/~pmcdonal/code.htm

Long-lived neutralino NLSPs

We investigate the collider signatures of heavy, long-lived, neutral particles that decay to charged particles plus missing energy. Specifically, we focus on the case of a neutralino NLSP decaying to Z and gravitino within the context of General Gauge Mediation. We show that a combination of searches using the inner detector and the muon spectrometer yields a wide range of potential early LHC discoveries for NLSP lifetimes ranging from 10−1 − 105 mm. We further show that events from Z(`+`−) can be used for detailed kinematic reconstruction, leading to accurate determinations of the neutralino mass and lifetime. In particular, we examine the prospects for detailed event study at ATLAS using the ECAL (making use of its timing and pointing capabilities) together with the TRT, or using the muon spectrometer alone. Finally, we also demonstrate that there is a region in parameter space where the Tevatron could potentially discover new physics in the delayed Z(`+`−) + 6ET channel. While our discussion centers on gauge mediation, many of the results apply to any scenario with a long-lived neutral particle decaying to charged particles.Physic

Prompt decays of general neutralino NLSPs at the Tevatron

Recent theoretical developments have shown that gauge mediation has a much larger parameter space of possible spectra and mixings than previously considered. Motivated by this, we explore the collider phenomenology of gauge mediation models where a general neutralino is the lightest MSSM superpartner (the NLSP), focusing on the potential reach from existing and future Tevatron searches. Promptly decaying general neutralino NLSPs can give rise to final states involving missing energy plus photons, Zs, Ws and/or Higgses. We survey the final states and determine those where the Tevatron should have the most sensitivity. We then estimate the reach of existing Tevatron searches in these final states and discuss new searches (or optimizations of existing ones) that should improve the reach. Finally we comment on the potential for discovery at the LHC.Physic

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Abstract Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4α. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy

Annulus Amplitudes and ZZ Branes in Minimal String Theory

We study the annulus amplitudes of (p,q) minimal string theory. Focusing on the ZZ-FZZT annulus amplitude as a target-space probe of the ZZ brane, we use it to confirm that the ZZ branes are localized in the strong-coupling region. Along the way we learn that the ZZ-FZZT open strings are fermions, even though our theory is bosonic! We also provide a geometrical interpretation of the annulus amplitudes in terms of the Riemann surface M_{p,q} that emerges from the FZZT branes. The ZZ-FZZT annulus amplitude measures the deformation of M_{p,q} due to the presence of background ZZ branes; each kind of ZZ-brane deforms only one A-period of the surface. Finally, we use the annulus amplitudes to argue that the ZZ branes can be regarded as "wrong-branch" tachyons which violate the bound \alpha<Q/2.Comment: 33 pages, new results in appendix, minor change

How Do Black Holes Predict the Sign of the Fourier Coefficients of Siegel Modular Forms?

Single centered supersymmetric black holes in four dimensions have spherically symmetric horizon and hence carry zero angular momentum. This leads to a specific sign of the helicity trace index associated with these black holes. Since the latter are given by the Fourier expansion coefficients of appropriate meromorphic modular forms of Sp(2,Z) or its subgroup, we are led to a specific prediction for the signs of a subset of these Fourier coefficients which represent contributions from single centered black holes only. We explicitly test these predictions for the modular forms which compute the index of quarter BPS black holes in heterotic string theory on T^6, as well as in Z_N CHL models for N=2,3,5,7.Comment: LaTeX file, 17 pages, 1 figur

A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders

Acknowledgements The authors acknowledge support from their associated institutions which included: (i) the Intramural Research Program, National Institute on Aging, NIH, USA, (ii) the Karolinska Institutet, Sweden, (iii) Aevisbio Inc., USA, (iv) Aevis Bio Inc., Republic of Korea, (v) G. d’Annunzio University of Chieti and Pescara, Italy, and (vi) University of Aberdeen, Scotland, UK. Funding The generation of this article was supported by: (i) the Intramural Research Program, National Institute on Aging, NIH: AG000994. (ii) The Technology Development Program of MSS, Republic of Korea (S2782046). (iii) The National Research Foundation (NRF) grant funded by the Republic of Korea Government (2021M3A9G2015889).Peer reviewedPublisher PD

Open/Closed String Duality for Topological Gravity with Matter

The exact FZZT brane partition function for topological gravity with matter is computed using the dual two-matrix model. We show how the effective theory of open strings on a stack of FZZT branes is described by the generalized Kontsevich matrix integral, extending the earlier result for pure topological gravity. Using the well-known relation between the Kontsevich integral and a certain shift in the closed-string background, we conclude that these models exhibit open/closed string duality explicitly. Just as in pure topological gravity, the unphysical sheets of the classical FZZT moduli space are eliminated in the exact answer. Instead, they contribute small, nonperturbative corrections to the exact answer through Stokes' phenomenon.Comment: 23 pages, 1 figure, harvma

General Neutralino NLSPs at the Early LHC

Gauge mediated supersymmetry breaking (GMSB) is a theoretically well-motivated framework with rich and varied collider phenomenology. In this paper, we study the Tevatron limits and LHC discovery potential for a wide class of GMSB scenarios in which the next-to-lightest superpartner (NLSP) is a promptly-decaying neutralino. These scenarios give rise to signatures involving hard photons, $W$'s, $Z$'s, jets and/or higgses, plus missing energy. In order to characterize these signatures, we define a small number of minimal spectra, in the context of General Gauge Mediation, which are parameterized by the mass of the NLSP and the gluino. Using these minimal spectra, we determine the most promising discovery channels for general neutralino NLSPs. We find that the 2010 dataset can already cover new ground with strong production for all NLSP types. With the upcoming 2011-2012 dataset, we find that the LHC will also have sensitivity to direct electroweak production of neutralino NLSPs.Comment: 26 page