高位脛骨骨切り術による膝アライメント矯正は、マクロファージの表現型がM1からM2に変化することに伴い、変形性膝関節症における症状および滑膜の炎症を軽減させる

京都大学新制・課程博士博士(医学)甲第24829号医博第4997号新制||医||1067(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 森信, 暁雄, 教授 竹内, 理, 教授 濵﨑, 洋子学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Torsional vibration reduction with augmented inverse model-based controller in wind turbine drivetrain

Wind energy has shown promising advantages in reducing the greenhouse effect by minimizing carbon dioxide emissions to improve earth climate. Wind turbine which falls under the umbrella of renewable energy family promises cleaner environment while generating electricity from wind energy with no burnt fossil fuel. However, it portrays challenges in terms of high operating cost due to component failure. Thus this paper discusses on mitigating one of the problems related to wind turbine failure, the torsional vibration reduction in drive train. A generator torque control is investigated together with the particle swarm optimization technique in search for accurate parameters of the controller. This control strategy is a solution to low wind speed areas especially around South East Asian region. An augmented inverse model-based controller and band pass filter is proposed to obtain vibration attenuation at the dominant mode. The modelling endeavor is firstly obtained via particle swarm optimization search capability to obtain an accurate transfer function of the inverse model. A band pass filter (BPF) is then augmented with the inverse model as controller for torsional vibration suppression. Results have shown favorable comparison between the proposed and conventional methods in terms of vibration attenuation level

Development of the dynamic motion simulator of 3D micro-gravity with a combined passive/active suspension system

The establishment of those in-orbit operations like 'Rendez-Vous/Docking' and 'Manipulator Berthing' with the assistance of robotics or autonomous control technology, is essential for the near future space programs. In order to study the control methods, develop the flight models, and verify how the system works, we need a tool or a testbed which enables us to simulate mechanically the micro-gravity environment. There have been many attempts to develop the micro-gravity testbeds, but once the simulation goes into the docking and berthing operation that involves mechanical contacts among multi bodies, the requirement becomes critical. A group at the Tokyo Institute of Technology has proposed a method that can simulate the 3D micro-gravity producing a smooth response to the impact phenomena with relatively simple apparatus. Recently the group carried out basic experiments successfully using a prototype hardware model of the testbed. This paper will present our idea of the 3D micro-gravity simulator and report the results of our initial experiments

Morphological Observations of Rabbit Gastric Fundus Cells in Primary Culture

The morphological properties of the cells isolated from rabbit gastric fundus and the cells grown on a collagen gel sheet were investigated, using both light and scanning electron microscopes. The cells used for this study were obtained in the form of lumps from the isthmus region. The lumps consisted of 4 different types of cells (mucous and immatured cells, and a small number of chief and parietal cells). These isolated cells were then grow on collagen gel in a defined medium. However, two of those cells (chief and parietal cells) gradually disappeared as the culture time progressed. The majority of the cells grown on the gel were found to be mucous and assorted unidentified cells. The mucous cells were covered with many short microvilli, and many PAS positive granules in their cytoplasm. Some of those cells were covered with a mucous like substance. Judging from the staining properties of each cell, the unidentified cells appeared to indicate that they were immature cells. It was found that the cell's morphology and population retained constant regardless of whether Bh-EGF was administered or not

Role of MCP‐1 and MIP‐1α in retinal neovascularization during postischemic inflammation in a mouse model of retinal neovascularization

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141957/1/jlb0137.pd

Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro

The antihepatotoxic activity of ten components related to plants were investigated using freshly isolated hepatocytes which maintained specific liver functions such as glucagon-dependent glycogenolysis and albumin producibility. Six components of garlic, i.e., S-methyl cysteine, S-ethyl cysteine, S-propyl cysteine, S-allylmercapto cysteine, alliin and S-allyl cysteine, and two syringaresinols of ciuwjia were synthesized. Two ginsenosides were purified from extract of ginseng. Both syringaresinols and S-allyl cysteine at concentrations of 250ng/ml and 0.5μg/ml, respectively, completely suppressed cytotoxicity on hepatocytes by CC14, as judged from GPT level released in the culture medium and morphology of the hepatocytes in stained specimens. The same was observed with S-propyl cysteine, S-allylmercapto cysteine and two ginsenosides at concentrations of lOμg/ml or less. Alliin was also effective but suppressed only GPT leakage. Four positive control drugs used was less effective. S-methyl cysteine and S-ethyl cysteine showed no obvious effect in any concentrations