The association between ambient temperature and antimicrobial resistance of Klebsiella pneumoniae in China: a difference-in-differences analysis

IntroductionAntimicrobial resistance (AMR) of Klebsiella pneumoniae (K. pneumoniae) poses a significant global public health threat and is responsible for a high prevalence of infections and mortality. However, knowledge about how ambient temperature influences the AMR of K. pneumoniae is limited in the context of global warming.MethodsAMR data of 31 Chinese provinces was collected from the China Antimicrobial Resistance Surveillance System (CARSS) between 2014 and 2020. Socioeconomic and meteorological data were collected from the China Statistical Yearbook during the same period. A modified difference-in-differences (DID) approach was applied to estimate the association between ambient temperature and third-generation cephalosporin-resistant K. pneumoniae (3GCRKP) and carbapenem-resistant K. pneumoniae (CRKP). Furthermore, moderating effects of socioeconomic factors were also evaluated.ResultsEvery 1°C increase in annual average temperature was associated with a 4.7% (relative risk (RR):1.047, 95% confidence intervals (CI): 1.031–1.082) increase in the detection rate of 3GCRKP, and a 10.7% (RR:1.107, 95% CI: 1.011–1.211) increase in the detection rate of CRKP. The relationships between ambient temperature and 3GCRKP and CRKP were found to be moderated by socioeconomic status (GDP per capita, income per capita, and consumption per capita; the interaction p-values <0.05), where higher economic status was found to strengthen the effects of temperature on the detection rate of 3GCRKP and weaken the effects on the detection rate of CRKP.DiscussionAmbient temperature was found to be positively associated with AMR of K. pneumoniae, and this association was moderated by socioeconomic status. Policymakers should consider the impact of global warming and high temperatures on the spread of 3GCRKP and CRKP when developing strategies for the containment of AMR

Integrated glycomic analysis of ovarian cancer side population cells

Additional file 2. The category of representative lectins for glycan profiling

Fiber-Optical Sensors: Basics and Applications in Multiphase Reactors

sensor

Application of KHX Impeller in a Low-shear Stirred Bioreactor

In our previous work, a low-shear stirred bioreactor was explored. With a pitched blade turbine impeller downflow (PBTD) used, the shear stress generated is high compared with that in some low shear axial flow impellers. KHX impeller is an efficient axial flow impeller, which provides large onflow diffusivity and low shear force. In this work, the KHX impeller was applied in a lower-shear bioreactor and the performance of this reactor was evaluated and compared with that of the PBTD impeller. The experimental results show that the KHX impeller can disperse gas at lower power consumption and gives greater gas–liquid volumetric mass transfer coefficients than PBTD at the same power consumption. An empirical correlation for evaluating the mass transfer coefficient of the KHX impeller in the bioreactor is presented to provide reference for its industrial application

Chin. J. Chem. Eng.

In our previous work, a low-shear stirred bioreactor was explored. With a pitched blade turbine impeller downflow (PBTD) used, the shear stress generated is high compared with that in some low shear axial flow impellers. KHX impeller is an efficient axial flow impeller, which provides large onflow diffusivity and low shear force. In this work, the KHX impeller was applied in a lower-shear bioreactor and the performance of this reactor was evaluated and compared with that of the PBTD impeller. The experimental results show that the KHX impeller can disperse gas at lower power consumption and gives greater gas-liquid volumetric mass transfer coefficients than PBTD at the same power consumption. An empirical correlation for evaluating the mass transfer coefficient of the KHX impeller in the bioreactor is presented to provide reference for its industrial application. (C) 2014 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.In our previous work, a low-shear stirred bioreactor was explored. With a pitched blade turbine impeller downflow (PBTD) used, the shear stress generated is high compared with that in some low shear axial flow impellers. KHX impeller is an efficient axial flow impeller, which provides large onflow diffusivity and low shear force. In this work, the KHX impeller was applied in a lower-shear bioreactor and the performance of this reactor was evaluated and compared with that of the PBTD impeller. The experimental results show that the KHX impeller can disperse gas at lower power consumption and gives greater gas-liquid volumetric mass transfer coefficients than PBTD at the same power consumption. An empirical correlation for evaluating the mass transfer coefficient of the KHX impeller in the bioreactor is presented to provide reference for its industrial application. (C) 2014 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved

A Novel Visual Narrative Framework for Tourist Map Design Based on Local Chronicles: A Case Study of the Songshan Scenic Area

Tourist maps provide tourists with destination information that reflects their unique characteristics and cultural connotations and play an important role in attracting tourists and serving marketing purposes. However, existing designs of tourist maps often ignore the importance of cultural resource selection and the relationship between maps and structural linguistics, thereby affecting the narrative function and representativeness of tourist maps. This study utilizes the local chronicle as a data source and proposes a novel visual narrative framework (VNF) for tourist maps. The VNF combines Todorov’s narrative hierarchy and Roth’s visual storytelling tropes to establish a mapping between map elements and narrative elements. To demonstrate the effectiveness of the VNF, the Songshan Scenic Area was selected as a case study. By applying the VNF, highly characteristic and meaningful colors, figurative hand-painted symbols, and scene symbols are selected and integrated into the map design to enhance the artistic value and narrative of the map. This framework reveals the potential cultural value of local chronicles and can serve as a reference for other historical tourist cities, contributing to the preservation of local cultural heritage

Computational Fluid Dynamics Simulation and Experimental Measurement of Gas and Solid Holdup Distributions in a Gas-Liquid-Solid Stirred Reactor

The lack of convincing computational fluid dynamics models and basic experimental data makes it difficult to design and scale up a gas liquid solid three-phase stirred reactor such as in environmentally benign bioleaching processes. In this work, a steady state gas liquid solid Eulerian Eulerian multifluid model was developed to predict flow field and local phase holdup distribution. The measurements of gas and solid holdup distributions in a gas liquid solid stirred reactor were simultaneously obtained for the first time by a new improved sample withdrawal technique. The influence of the presence of a second dispersed phase on interphase drag force was taken into account, and good agreement for the local phase holdup was obtained between the predictions and the experimental data. The solid concentration increased, and the gas holdup decreased along the radial direction from the reactor axis to the wall. A simplified bubble-size model considering the effect of turbulence dissipation rate was incorporated in the model instead of a fixed size. It was found that smaller bubbles concentrated in the impeller region, and the bubble size increased near the free surface. The mixing efficiency could be enhanced obviously when double impellers were employed

Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model

The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation