Small Government in the 21st Century

In this paper we tried to consider the fiscal reconstruction processes in the United States and Japan mainly from the viewpoint of the "logic of taxpayers", which brings the pressures to control the costs of welfare state for the aged. But today\u27s pressures toward "small government" have one more purpose, to get rid of or to reduce the obstacles against market mechnism and economic growth, which are brought by interventions and regulations of government. In 21st century, because of the speed-up of the aging trend and the explosion of welfare state costs, I think, more reduction of governmental activities in many fields will be needed to promote economic growth and the resulting expansion of tax base. Many liberal policy measures, brought out by 20th century "big government", can not be maintained. Finally because of cost-explosion of the "aged-measure" part of the welfare state, the "nonaged-measure" part comes under much stricter pressures to be cut. I would hope that the representers and disputants in the second session add this viewpoint to their discussion

Installation of the superconducting gravimeter CT(#043) at Syowa Station, Antarctica

During the wintering period of the 44th Japanese Antarctic Research Expedition (JARE-44: February 2003 to January 2004), a new superconducting gravimeter CT(#043) with a cryocooler was installed and tested to replace the former TT70(#016) at Syowa Station, Antarctica. The CT(#043) has design sensitivity of 1nGal (1×10^(-11)m/s^2) to study the Earth\u27s dynamics in tidal and longer-period bands. A new type of diaphragm was used to effectively isolate the vibration from the refrigerator cold-head and to prevent solid air contamination from entering the Dewar. A real-time remote monitoring system including a Web camera for diagnostics from Japan has also been installed

Analysis of the Cost-effectiveness of Photodynamic Therapy in Early Stage Lung Cancer

Methods A cost-effectiveness analysis was carried out for photodynamic therapy (PDT) performed in early stage lung cancer cases, which by definition have no lymph node metastasis. The alternative treatment method was lobectomy, which conventionally would have been the first choice of treatment. Costs (C) and effectiveness (E) both of the PDT group and operation group were compared. Effectiveness was determined using quality adjusted life years saved (QALYs) which is the 5-year survival rate adjusted in terms of the quality of life of the patient, and the cost-effectiveness rate was obtained based on the costs of treatment methods during the patient's stay in the hospital. Health care costs, including drugs, were calculated according to the 1992 National Health Insurance list in yen. Costs which were non-reimbursable by the public insurance system, such as for special rooms and sun block cream, were also expressed in yen

Sclerosing angiomatoid nodular transformation of the spleen masquerading as a sarcoma metastasis

We report a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen presenting as an incidental splenic mass in a patient with a history of retroperitoneal spindle cell sarcoma. Imaging studies and preoperative fine needle biopsy failed to differentiate this lesion from other vascular splenic lesions or a metastatic focus of a prior sarcoma. The patient was treated with splenectomy, which has proved both diagnostic and therapeutic in this and other cases of SANT. Although histology can lead to the diagnosis of vascular tumor, immunohistochemistry is the only way to confirm the diagnosis of SANT. The etiology of SANT is unknown. SANT of the spleen is a benign lesion that does not recur after splenectomy

Finding Useful Detours in Geographical Databases

In geographical databases for navigation, users raise various types of queries concerning route guidance. The most fundamental query is a shortest-route query, but, as dynamical traffic information newly becomes available and the static geographical database of roads itself has grown up further, more flexible queries are required to realize a user-friendly interface meeting the current settings. One important query among them is a detour query which provides information about detours, say listing several candidates for useful detours. This paper first reviews algorithms for the shortest and k shortest paths, and discusses their extensions to detour queries. Algorithms for finding a realistic detour are given. The efficiency and property of the algorithms are examined through experiments on an actual road network.PAPE

Study of hadron interactions in a lead-emulsion target

Topological and kinematical characteristics of hadron interactions have been studied using a lead-emulsion target exposed to 2, 4 and 10 GeV/c hadron beams. A total length of 60 m $\pi^-$ tracks was followed using a high speed automated emulsion scanning system. A total of 318 hadron interaction vertices and their secondary charged particle tracks were reconstructed. Measurement results of interaction lengths, charged particle multiplicity, emission angles and momenta of secondary charged particles are compared with a Monte Carlo simulation and appear to be consistent. Nuclear fragments emitted from interaction vertices were also detected by a newly developed emulsion scanning system with wide-angle acceptance. Their emission angle distributions are in good agreement with the simulated distributions. Probabilities of an event being associated with at least one fragment track are found to be greater than 50% for beam momentum $P > 4$ GeV/c and are well reproduced by the simulation. These experimental results validate estimation of the background due to hadron interactions in the sample of $\tau$ decay candidates in the OPERA $\nu_{\mu} \to \nu_{\tau}$ oscillation experiment.Comment: 14 pages, 11 figure

IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia

T cells infected with human T-cell leukemia virus type 1 (HTLV-1) transform into malignant/leukemic cells and develop adult T-cell leukemia (ATL) after a long latency period. The tax (transactivator from the X-gene region) and HBZ (HTLV-1 bZIP factor) genes of HTLV-1 play crucial roles in the development of ATL. The process and mechanism by which HTLV-1-infected T cells acquire malignancy and develop ATL remain to be elucidated. Constitutive expression of interleukin-2 (IL-2) receptor α-chain (IL-2Rα/CD25), induced by the tax and HBZ genes of HTLV-1, on ATL cells implicates the involvement of IL-2/IL-2R pathway in the growth and development of ATL cells in vivo. However, the leukemic cells in the majority of ATL patients appeared unresponsive to IL-2, raising controversies on the role of this pathway for the growth of ATL cells in vivo. Here, we report the establishment of 32 IL-2-dependent T-cell lines infected with HTLV-1 from 26 ATL patients, including eight leukemic cell lines derived from five ATL patients, while no T-cell lines were established without IL-2. We have shown that the IL-2-dependent ATL cell lines evolved into IL-2-independent/-unresponsive growth phase, resembling ATL cells in vivo. Moreover, the IL-2-dependent non-leukemic T-cell lines infected with HTLV-1 acquired IL-2-independency and turned into tumor-producing cancer cells as with the ATL cell lines. HTLV-1-infected T cells in vivo could survive and proliferate depending on IL-2 that was produced in vivo by the HTLV-1-infected T cells of ATL patients and patients with HTLV-1-associated diseases and, acts as a physiological molecule to regulate T-cell growth. These results suggest that ATL cells develop among the HTLV-1-infected T cells growing dependently on IL-2 and that most of the circulating ATL cells progressed to become less responsive to IL-2, acquiring the ability to proliferate without IL-2