An FEM Study of the Effect of Temperature on the Design of Reliable Micro Electrical Contact

This paper presents the effect of temperature on the design of reliable micro electrical contact. Micro switch suitable for power switching applications is considered. The structure, voltage- current and power characteristics of the micro electrical contact are discussed. The current carrying capability and power withstanding capability of the micro electrical contact are predicted based on the temperature. The role of temperature for the reliable micro electrical contact is identified. The heating time of the micro electrical contact are also obtained. The reliable switching in terms of temperature is discussed. The analysis is carried out for the contact metals Al, Cu, Au and Pt. In order to predict the temperature COMSOL FEM simulations are carried out and presented

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.</p