平成28年度 金沢大学退職者懇談会挨拶

2017年3月28日 平成28年度『金沢大学退職者懇談会 於：金沢大学中福利食堂』における挨拶原

金沢大学の「スーパーグローバル人材」育成戦略

平成28年11月26日 (一財)進学基準研究機構(CEES) 第2回シンポジウム 『大学入試改革と変わる小中高大の教育』/初等中等教育，高等教育のそれぞれで進むグローバル人材育成, 於：ベルサール高田馬場 金沢大学副学長 柴田正良先生インタビュー記

増殖期および分化期におけるマウス初期神経幹細胞に対する持続的メチル水銀暴露の影響

Methylmercury (MeHg) is a potent neurotoxin that causes Minamata disease and is particularly harmful during pregnancy, causing abnormal pregnancy or various adverse effects including congenital Minamata disease. Neural stem cells (NSCs) can proliferate and differentiate into neurons and glia, playing a key role in the formation of the CNS. Here, we examined the effects of continuous exposure of homogeneous embryonic stem cell-derived primitive NSCs to MeHg in the proliferation and differentiation stages. Cultured without MeHg in the proliferation stage, NSCs showed an exponential increase in the number of the cells up to day 4. However, continuous exposure of NSCs to MeHg induced apoptosis and caused a decrease in the number of NSCs in a dose- and time-dependent manner. Continuous exposure of NSCs to MeHg in the differentiation stage also caused a decrease in the number of NSCs but had no or little effect on differentiation from surviving NSCs into neurons and glia. The NSCs were about 20 times more susceptible to MeHg in the proliferation stage than the differentiation stage. These effects of continuous MeHg exposure on NSCs may be valuable in elucidating the mechanisms by which MeHg exposure during pregnancy causes congenital Minamata disease and reproductive problems. In particular, the present results suggests that MeHg even at a very low concentration may decrease the number of proliferating NSCs in the early stages of development of central nervous system (CNS) and cause shortage of NSCs required for normal development of CNS.首都大学東京, 2016-03-25, 博士（健康科学）, 乙第126号首都大学東

Toward robot ethics through the ethics of autism

The aim of this chapter is to present an ethical landscape for humans and autonomous robots in the future of a physicalistic world, and which will touch mainly on a framework of robot ethics rather than the concrete ethical problems possibly caused by recent robot technologies. It might be difficult to find sufficient answers to such ethical problems as those occurring with future military robots unless we understand what autonomy in autonomous robots exactly implies for robot ethics. This chapter presupposes that this “autonomy” should be understood as “being able to make intentional decisions from the internal state, and to doubt and reject any rule, ” a definition which requires robots to have at least a minimal folk psychology in terms of desire and belief. And if any agent has a minimal folk psychology, we would have to say that it potentially has the same “right and duties” as we humans with a fully fledged folk psychology, because ethics for us would cover any agent as far as it is regarded to have a folk psychology – even in Daniel C. Dennett\u27s intentional stance (Dennett, 1987). We can see the lack of autonomy in this sense in the famous Asimov\u27s laws (Asimov, 2000) cited by Bekey et al. in Chapter 14 of this volume, which could be interpreted to show the rules any autonomous robots in the future have to obey (see Section 14.3). © Cambridge University Press 2011.Book Chapte

Immunoreactivity profiling of Anti-Chinese hamster ovarian host cell protein antibodies by isobaric labeled affinity purification-mass spectrometry reveals low-recovery proteins

We evaluated the immunoreactivity profiles of eight commercial anti-host cell protein (anti-HCP) antibodies from different host animals and their antigens used for immunization by an isobaric labeled affinity purification-mass spectrometry (AP-MS) method. As a result, 34 proteins with high abundance but low recovery from harvest cell culture fluid were identified. Since they are likely to be underestimated in biopharmaceutical quality assessment, the features common to these proteins were investigated. Compared to other immunoprecipitated HCP proteins, proteins exhibiting lower molecular weight (ΔMW = -14600), lower isoelectric point (ΔpI = -0.86), and lower hydrophobicity (ΔGRAVY = -0.13) were enriched. This AP-MS method provides important information for HCP control strategies using immunological methods and is expected to contribute to the development of safe biopharmaceutics

平成28年度 第60回 金沢美術工芸大学卒業式 ・ 第37回大学院修了式 祝辞

2017年3月1日『第60回 金沢美術工芸大学卒業式・第37回大学院修了式 於：金沢美術工芸大学』における祝辞原

金沢大学医学図書館竣工式「式辞」

2013年3月14日 金沢大学医学図書館竣工式 於：金沢大学附属図書館十全記念スタジオ 挨拶原