Diaqua­(nitrato-κ2 O,O′)[2-(1H-1,2,4-triazol-1-yl-κN 2)-1,10-phenanthroline-κ2 N,N′]cadmium(II) nitrate

In the title complex, [Cd(C14H9N5)(NO3)(H2O)2]NO3, the CdII ion is coordinated in a distorted penta­gonal-bipyramidal geometry. The equatorial sites are occupied by a 2-(1H-1,2,4-triazol-1-yl)-1,10-phenanthroline ligand in a tridentate coordination mode and a bis-chelating nitrate ligand. Two aqua ligands are coordinated at the axial sites. All non-H atoms in the equatorial plane are co-planar within 0.0673 Å. In the crystal, inter­molecular O—H⋯O and O—H⋯N hydrogen bonds connect the components into a two-dimensional network parallel to (001). In addition, there is a π–π stacking inter­action between symmetry-related benzene rings, with a centroid–centroid distance of 3.598 (3) Å

From Type-II Triply Degenerate Nodal Points and Three-Band Nodal Rings to Type-II Dirac Points in Centrosymmetric Zirconium Oxide

Using first-principles calculations, we report that ZrO is a topological material with the coexistence of three pairs of type-II triply degenerate nodal points (TNPs) and three nodal rings (NRs), when spin-orbit coupling (SOC) is ignored. Noticeably, the TNPs reside around Fermi energy with large linear energy range along tilt direction (> 1 eV) and the NRs are formed by three strongly entangled bands. Under symmetry-preserving strain, each NR would evolve into four droplet-shaped NRs before fading away, producing distinct evolution compared with that in usual two-band NR. When SOC is included, TNPs would transform into type-II Dirac points while all the NRs have gaped. Remarkably, the type-II Dirac points inherit the advantages of TNPs: residing around Fermi energy and exhibiting large linear energy range. Both features facilitate the observation of interesting phenomena induced by type-II dispersion. The symmetry protections and low-energy Hamiltonian for the nontrivial band crossings are discussed.Comment: 7 pages, 5 figures, J. Phys. Chem. Lett. 201

Therapeutic effect of Lianbeijuqin (a Chinese herbal cocktail) on periodontitis in rat

Purpose: To investigate the therapeutic effect of Lianbeijuqin (LBJQ) decoction on periodontitis in rats in vivo and in vitro.Methods: High performance liquid chromatography (HPLC) was used to analyze the main constituents of LBJQ. Periodontitis in rats was induced in rats by ligation with bacteria-infected silk. Gingival index (GI) and attachment loss (AL) were evaluated. Additionally, the antibacterial activity of LBJQ against Porphyromonas gingivalis, Prevotella intermedius, Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Streptococcus sanguis and Streptococcus mutans were evaluated usingminimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values. Furthermore, the inhibitory effect of LBJQ on the release of TNF-α, IL-1 β and IL-6 was also determined.Results: HPLC revealed the presence of phellodendrine, baicalin, palmatine, berberine, baicalein, wogonin and obacunone in LBJQ. LBJQ decoction  dose-dependently (200, 400 and 800 mg/kg) and significantly decreased GI and AL (p < 0.05) in the periodontitis model rats. It also exerted significant antibacterial effect against P. gingivalis (MIC, 0.64 mg/mL; MBC, 2.56 mg/mL), P. intermedius (MIC, 0.32 mg/m; MBC, 2.56 mg/mL), A. actinomycetemcomitans (MIC, 1.28 mg/mL; MBC, 5.12 mg/mL), F. nucleatum (MIC, 0.16 mg/mL; MBC, 0.64 mg/mL), S. sanguis (MIC, 0.64 mg/mL; MBC, 5.12 mg/mL), and S. mutans (MIC, 0.16 mg/mL; MBC, 1.28 mg/mL). Moreover, LBJQ decoction dose-dependently and significantly decreased the release of TNF-α (p < 0.01), IL-1 β (p < 0.01) and IL-6 (p < 0.01) in LPSinduced RAW 264.7 cells.Conclusion: LBJQ exerts therapeutic activity against periodontitis in rats via  inhibition of the release of inflammatory cytokines and growth of oral anaerobic  bacteria.Keywords: Lianbeijuqin decoction, Periodontitis, Phellodendrine, Baicalin, Palmatine, Berberine, Porphyromonas gingivalis, Prevotella intermedius, Inflammatory cytokine