A társadalmak környezeti sebezhetősége, ellenálló- és alkalmazkodó képessége:a korai történelmi példáktól a sérülékenység globalizációjáig (Environmental vulnerability, resilience and adaptation capacities of societies: their historical examples and globalization)

Detailed phylogenetic tree of the haplogroup Q3-L275. 47 Q3-L275 samples and 1 Q1a-M346 outgroup. Constructed with the Phylomurka software using MP criteria, from the alignment obtained with read depth > = 2, base quality > = 15 and mapping quality > = 10, call rate = 60%. (XLSX 279 kb

sj-docx-1-jrc-10.1177_00224278221120677 - Supplemental material for Trends in Prison Sentences and Racial Disparities: 20-Years of Sentencing Under Florida’s Criminal Punishment Code

Supplemental material, sj-docx-1-jrc-10.1177_00224278221120677 for Trends in Prison Sentences and Racial Disparities: 20-Years of Sentencing Under Florida’s Criminal Punishment Code by Ojmarrh Mitchell, Shi Yan and Daniela Oramas Mora in Journal of Research in Crime and Delinquency</p

Electrospun Nanofiber-Based Thermite Textiles and their Reactive Properties

In this work, we present a first time fabrication of thermite-based nanofiber mats with a nitrocellulose composite energetic binder to create a new class of energetic 1D nanocomposite. The as prepared thermite based nanofibrous mats were characterized and tested for their burning behavior, and compared with the pure nitrocellulose and nanoaluminum incorporated nanofibers for their combustion performances. Thermite-based nanofibers show enhanced burning rates in combustion tests, which correlate to the mass loading of nanothermite relative to binder in nanofibers. The electrospinning method demonstrates the possibility of avoiding some of the problems associated with melt casting nanometalized propellants

Comparisons of <i>Caenorhabditis</i> Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N‑Glycan Structures

Recent studies have shown a remarkable degree of plasticity in the N-glycome of the model nematode <i>Caenorhabditis elegans</i>; ablation of glycosylation-relevant genes can result in radically altered N-glycan profiles despite only minor biological phenotypic effects. Up to four fucose residues and five different linkages of fucose are known on the N-glycans of <i>C. elegans</i>. Due to the complexity in the wild type, we established three mutant strains defective in two core fucosyltransferases each (<i>fut-1;fut-6</i>, <i>fut-1;fut-8</i>, and <i>fut-6;fut-8</i>). Enzymatically released N-glycans were subject to HPLC and MALDI-TOF MS/MS, in combination with various treatments, to verify structural details. The N-glycome of the <i>fut-1;fut-6</i> mutant was the most complex of the three double-mutant strains due to the extension of the core α1,6-fucose as well as the presence of fucose on the bisecting galactose. In contrast, maximally two fucoses were found on N-glycans of the <i>fut-1;fut-8</i> and <i>fut-6;fut-8</i> strains. The different locations and capping of fucose meant that up to 13 isomeric structures, many highly galactosylated, were determined for some single masses. These data not only show the high variability of the N-glycomic capacity of a “simple” nematode but also exemplify the need for multiple approaches to reveal individual glycan structures within complex invertebrate glycomes

Urinary Nerve Growth Factor Could Be a Biomarker for Interstitial Cystitis/Painful Bladder Syndrome: A Meta-Analysis

<div><p>To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared to those of healthy people (SMD = 1.94, 95%CI = 0.79–3.08, P = 0.0009 and SMD = 1.79, 95%CI = 0.65–2.93, P = 0.002, respectively). In addition, there was a significant difference between patients with IC/PBS and patients with overactive bladder (OAB) symptoms with respect to the urinary NGF and NGF/Cr levels (SMD = −0.62, 95%CI = −1.00–−0.24, P = 0.001 and SMD = −0.70, 95%CI = −1.01–−0.39, P<0.0001, respectively). Furthermore, patients had a significantly lower urinary NGF level after successful treatment (SMD = 1.74, 95%CI = 0.32–3.17, P = 0.02). In conclusion, urinary NGF could be a useful biomarker for the diagnosis of OAB, a urinary biomarker for the differential diagnosis of IC/PBS and OAB (when a critical urinary NGF or NGF/Cr level is needed), and a predictive biomarker to help guide treatment.</p></div

Differences in the urinary NGF and NGF/Cr levels between patients with IC/PBS and patients with OAB.

<p>A: NGF level. IC/PBS patients presented a lower urinary NGF level compared to that of overactive bladder (OAB) patients (SMD = −0.62, 95%CI = −1.00–−0.24, P = 0.001); B: NGF/Cr level. IC/PBS patients presented a lower urinary NGF/Cr level compared to that of OAB patients (SMD = −0.70, 95%CI = −1.01–−0.39, P<0.0001).</p

Effect of 5-Fu on cell viability assessed by the MTT method (uM).

<p>IC50 is the half maximal inhibitory concentration. The IC50 ± sd were calculated based on the results of three independent experiments.</p

Demographics and chronic disease patterns by segments.

<p>Demographics and chronic disease patterns by segments.</p

Sequencing chromatograms of <i>MTDH</i> (−470G>A).

<p>A–C, the sequencing chromatogram results of the genotype GG, GA and AA respectively. Samples were chosen randomly.</p

The association between the urinary NGF or NGF/Cr level and IC/PBS.

<p>A: NGF level. Interstitial cystitis/painful bladder syndrome (IC/PBS) patients presented a higher urinary NGF level compared to that of controls (SMD = 1.94, 95%CI = 0.79–3.08, P = 0.0009); B: NGF/Cr level. IC/PBS patients presented a higher urinary NGF/Cr level compared to that of controls (SMD = 1.79, 95%CI = 0.65–2.93, P = 0.002).</p