68 research outputs found
A társadalmak környezeti sebezhetősége, ellenálló- és alkalmazkodó képessége:a korai történelmi példáktól a sérülékenység globalizációjáig (Environmental vulnerability, resilience and adaptation capacities of societies: their historical examples and globalization)
Detailed phylogenetic tree of the haplogroup Q3-L275. 47 Q3-L275 samples and 1 Q1a-M346 outgroup. Constructed with the Phylomurka software using MP criteria, from the alignment obtained with read depth > = 2, base quality > = 15 and mapping quality > = 10, call rate = 60%. (XLSX 279 kb
sj-docx-1-jrc-10.1177_00224278221120677 - Supplemental material for Trends in Prison Sentences and Racial Disparities: 20-Years of Sentencing Under Florida’s Criminal Punishment Code
Supplemental material, sj-docx-1-jrc-10.1177_00224278221120677 for Trends in Prison Sentences and Racial Disparities: 20-Years of Sentencing Under Florida’s Criminal Punishment Code by Ojmarrh Mitchell, Shi Yan and Daniela Oramas Mora in Journal of Research in Crime and Delinquency</p
Electrospun Nanofiber-Based Thermite Textiles and their Reactive Properties
In this work, we present a first
time fabrication of thermite-based
nanofiber mats with a nitrocellulose composite energetic binder to
create a new class of energetic 1D nanocomposite. The as prepared
thermite based nanofibrous mats were characterized and tested for
their burning behavior, and compared with the pure nitrocellulose
and nanoaluminum incorporated nanofibers for their combustion performances.
Thermite-based nanofibers show enhanced burning rates in combustion
tests, which correlate to the mass loading of nanothermite relative
to binder in nanofibers. The electrospinning method demonstrates the
possibility of avoiding some of the problems associated with melt
casting nanometalized propellants
Comparisons of <i>Caenorhabditis</i> Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N‑Glycan Structures
Recent studies have
shown a remarkable degree of plasticity in
the N-glycome of the model nematode <i>Caenorhabditis elegans</i>; ablation of glycosylation-relevant genes can result in radically
altered N-glycan profiles despite only minor biological phenotypic
effects. Up to four fucose residues and five different linkages of
fucose are known on the N-glycans of <i>C. elegans</i>.
Due to the complexity in the wild type, we established three mutant
strains defective in two core fucosyltransferases each (<i>fut-1;fut-6</i>, <i>fut-1;fut-8</i>, and <i>fut-6;fut-8</i>).
Enzymatically released N-glycans were subject to HPLC and MALDI-TOF
MS/MS, in combination with various treatments, to verify structural
details. The N-glycome of the <i>fut-1;fut-6</i> mutant
was the most complex of the three double-mutant strains due to the
extension of the core α1,6-fucose as well as the presence of
fucose on the bisecting galactose. In contrast, maximally two fucoses
were found on N-glycans of the <i>fut-1;fut-8</i> and <i>fut-6;fut-8</i> strains. The different locations and capping
of fucose meant that up to 13 isomeric structures, many highly galactosylated,
were determined for some single masses. These data not only show the
high variability of the N-glycomic capacity of a “simple”
nematode but also exemplify the need for multiple approaches to reveal
individual glycan structures within complex invertebrate glycomes
Urinary Nerve Growth Factor Could Be a Biomarker for Interstitial Cystitis/Painful Bladder Syndrome: A Meta-Analysis
<div><p>To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared to those of healthy people (SMD = 1.94, 95%CI = 0.79–3.08, P = 0.0009 and SMD = 1.79, 95%CI = 0.65–2.93, P = 0.002, respectively). In addition, there was a significant difference between patients with IC/PBS and patients with overactive bladder (OAB) symptoms with respect to the urinary NGF and NGF/Cr levels (SMD = −0.62, 95%CI = −1.00–−0.24, P = 0.001 and SMD = −0.70, 95%CI = −1.01–−0.39, P<0.0001, respectively). Furthermore, patients had a significantly lower urinary NGF level after successful treatment (SMD = 1.74, 95%CI = 0.32–3.17, P = 0.02). In conclusion, urinary NGF could be a useful biomarker for the diagnosis of OAB, a urinary biomarker for the differential diagnosis of IC/PBS and OAB (when a critical urinary NGF or NGF/Cr level is needed), and a predictive biomarker to help guide treatment.</p></div
Differences in the urinary NGF and NGF/Cr levels between patients with IC/PBS and patients with OAB.
<p>A: NGF level. IC/PBS patients presented a lower urinary NGF level compared to that of overactive bladder (OAB) patients (SMD = −0.62, 95%CI = −1.00–−0.24, P = 0.001); B: NGF/Cr level. IC/PBS patients presented a lower urinary NGF/Cr level compared to that of OAB patients (SMD = −0.70, 95%CI = −1.01–−0.39, P<0.0001).</p
Effect of 5-Fu on cell viability assessed by the MTT method (uM).
<p>IC50 is the half maximal inhibitory concentration. The IC50 ± sd were calculated based on the results of three independent experiments.</p
Demographics and chronic disease patterns by segments.
<p>Demographics and chronic disease patterns by segments.</p
Sequencing chromatograms of <i>MTDH</i> (−470G>A).
<p>A–C, the sequencing chromatogram results of the genotype GG, GA and AA respectively. Samples were chosen randomly.</p
The association between the urinary NGF or NGF/Cr level and IC/PBS.
<p>A: NGF level. Interstitial cystitis/painful bladder syndrome (IC/PBS) patients presented a higher urinary NGF level compared to that of controls (SMD = 1.94, 95%CI = 0.79–3.08, P = 0.0009); B: NGF/Cr level. IC/PBS patients presented a higher urinary NGF/Cr level compared to that of controls (SMD = 1.79, 95%CI = 0.65–2.93, P = 0.002).</p
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