Linking GloVe with word2vec

The Global Vectors for word representation (GloVe), introduced by Jeffrey Pennington et al. is reported to be an efficient and effective method for learning vector representations of words. State-of-the-art performance is also provided by skip-gram with negative-sampling (SGNS) implemented in the word2vec tool. In this note, we explain the similarities between the training objectives of the two models, and show that the objective of SGNS is similar to the objective of a specialized form of GloVe, though their cost functions are defined differently.Comment: 5 pages, 2 figure

Global Transition-based Non-projective Dependency Parsing

Shi, Huang, and Lee (2017) obtained state-of-the-art results for English and Chinese dependency parsing by combining dynamic-programming implementations of transition-based dependency parsers with a minimal set of bidirectional LSTM features. However, their results were limited to projective parsing. In this paper, we extend their approach to support non-projectivity by providing the first practical implementation of the MH_4 algorithm, an $O(n^4)$ mildly nonprojective dynamic-programming parser with very high coverage on non-projective treebanks. To make MH_4 compatible with minimal transition-based feature sets, we introduce a transition-based interpretation of it in which parser items are mapped to sequences of transitions. We thus obtain the first implementation of global decoding for non-projective transition-based parsing, and demonstrate empirically that it is more effective than its projective counterpart in parsing a number of highly non-projective languagesComment: Proceedings of ACL 2018. 13 page

Rigidity and non-rigidity of \H^n/\Z^{n-2} with scalar curvature bounded from below

We show that the hyperbolic manifold \H^n/\Z^{n-2} is not rigid under all compactly supported deformations that preserve the scalar curvature lower bound $-n(n-1)$, and that it is rigid under deformations that are further constrained by certain topological conditions. In addition, we prove two related splitting results.Comment: 29 pages, 3 figures, all comments are welcome

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.

Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells. KMT2A knockdown significantly inhibited cell viability and cell migration and induced apoptosis, whereas KMT2A overexpression effectively promoted cell proliferation in various melanoma cell lines. Further study showed that KMT2A regulated melanoma cell growth by targeting the hTERT-dependent signal pathway. Knockdown of KMT2A markedly inhibited the promoter activity and expression of hTERT, and hTERT overexpression rescued the viability inhibition caused by KMT2A knockdown. Moreover, KMT2A knockdown suppressed tumorsphere formation and the expression of cancer stem cell markers, which was also reversed by hTERT overexpression. In addition, the results from a xenograft mouse model confirmed that KMT2A promoted melanoma growth via hTERT signaling. Finally, analyses of clinical samples demonstrated that the expression of KMT2A and hTERT were positively correlated in melanoma tumor tissues, and KMT2A high expression predicted poor prognosis in melanoma patients. Collectively, our results indicate that KMT2A promotes melanoma growth by activating the hTERT signaling, suggesting that the KMT2A/hTERT signaling pathway may be a potential therapeutic target for melanoma

Climate-Driven Changes in High-Intensity Wildfire on Orbital Timescales in Eurasia since 320 ka

AbstractWildfire is an integral part of the Earth’s climate system and plays an important role in shaping terrestrial ecosystems and biodiversity, atmospheric chemistry, regional climate, and the carbon cycle in the Earth’s history. However, the lack of high-resolution records of long wildfires limits our understanding of the natural variability, long-term trends of wildfire activity, and the reasons behind the changes in wildfire on orbital timescales. Here, a 320 ka long high-resolution wildfire record from the subarctic North Pacific is reconstructed with black carbon (BC), including its two subtypes char and soot. A 7-day-long back trajectory simulation analysis reveals the higher frequency of trajectories comes from Siberia. Our data show that continuous incidence of wildfire on a continental scale over the last 320 ka was higher during glacial periods than during the interglacial periods. The increase in wildfire frequency during glacial periods is ascribed to less precipitation. Contrasting patterns of wildfire incidence between marine isotope stages 2 and 6 may be ascribed to different fuel availability, which is related to contrasting configurations of the Northern Hemisphere ice sheet between glacial periods. A significant periodicity of 23 ka of our wildfire record suggests the precession of the Earth’s orbit pace wildfire development. The tight coupling of intensified wildfire and enhanced nutrient utilization efficiency suggests a nontrivial role of fire in the climate system