Дифференциация 2- и 6-изомеров (2-метиламинопропил)бензофурана методом тандемной масс-спектрометрии

Reliable identification of new psychoactive substances of 2-(2-methylaminopropyl) benzofuran and 6-(2-methylaminopropyl)benzofuran is problematic when analyzing by gas chromatography–mass spectrometry method. It found that these two isomers can be reliably differentiated by MS/MS spectra obtained by collision-induced dissociation of their protonated molecules.Достоверная идентификация новых психоактивных соединений 2-(2-метиламинопропил) бензофурана и 6-(2-метиламинопропил)бензофурана проблематична при проведении анализа методом хроматомасс-спектрометрии. Установлено, что эти два изомера могут быть надежно дифференцированы по МС/МС спектрам, полученным в результате диссоциации, индуцируемой соударением, их протонированных молекул

Дифференциация 2- и 6- изомеров (2-метиламинопропил)бензофурана методом тандемной масс-спектрометрии

Reliable identification of new psychoactive substances of 2-(2-methylaminopropyl)benzofuran and 6-(2-methylaminopropyl)benzofuran is problematic when analyzing by gas chromatography–mass spectrometry method. It found that these two isomers can be reliably differentiated by MS/MS spectra obtained by collision-induced dissociation of their protonated molecules.Достоверная идентификация новых психоактивных соединений 2-(2-метиламинопропил)бензофурана и 6-(2-метиламинопропил)бензофурана проблематична при проведении анализа методом хроматомасс-спектрометрии. Установлено, что эти два изомера могут быть надежно дифференцированы по МС/МС спектрам, полученным в результате диссоциации, индуцируемой соударением, их протонированных молекул

Analytical characterization of some synthetic cannabinoids, derivatives of indole-3-carboxylic acid

By means of gas chromatography with high resolution mass spectrometry (GC-HRMS), ultra-high performance liquid chromatography in combination with high resolution tandem mass spectrometry (UHPLC-HRMS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FT-IR), structure of a series from a novel synthetic cannabinoids, derivatives of indole-3-carboxylic acid, was established. Methods for determination of the compounds in mixtures, involving chromatographic separation with mass-spectroscopic determination, were elaborated. Analytical data obtained in the paper will make reliable identification of synthetic cannabinoids of the new type during forensic examination possible. © 2013 Elsevier Ireland Ltd

Phytochemical screening and properties of botanical crude extracts and ethyl acetate fractions isolated by deep eutectic solvent

Botanicals, being safe because of their natural origin, are associated with potential health benefits due to their isoflavones-rich content. Isoflavones as plant-generated secondary metabolites are formed to defend against environmental stress such as UV radiation, mechanical damage, or any other attack from the surroundings. Kudzu (Pueraria roots and flowers), red clover (Trifolium pratense), and soy (Glycine max) are of significant importance in the medical field. Isoflavones were reported to exhibit a variety of biological functions, e.g., antiaging, anticancer, and microbiome modulations. This study focuses attention on the extraction and quantification of isoflavones from kudzu roots (KR), kudzu flowers (KF), red clover (RC), and soy molasses (SM), and determining their total polyphenols (TPC), flavonoids (TFC), and antioxidant activity (AOA). Novel green ultrasound-assisted extraction (UAE) technology was developed to extract and quantify the isoflavones. The results showed the quantity of isoflavones in KR, KF, RC, and SM crude extracts to be 1.01%, 2.9%, 0.70% and 0.67%, respectively. The fractionation using ethyl acetate (EA) improved the yield that became 1.48%, 2.5%, 1.3% and 0.89% in the KR, RC and SM extract fractions, respectively. This investigation eventually showed that our green UAE methodology is a safe and efficient method for recovering isoflavones. The total isoflavone contents were recorded as follows: KFKRRCSM. We concluded that these botanicals are a crucial source of isoflavones that exhibit strong antioxidant properties

Comparative study of extraction of soy molasses isoflavones and in vivo bioconversion of daidzein into S-equol in rats models

Received: February 8th, 2021 ; Accepted: April 24th, 2021 ; Published: April 30th, 2021 ; Correspondence: [email protected] compared different extraction methods for isolation of isoflavones from soybean molasses. Since conventional extraction methods are time-consuming, expensive and unsustainable, we have compared them with the NADES extraction method, which does not have these disadvantages. Fermentation-assisted technique and extraction with Natural Deep Eutectic Solvents (NADES) were compared to the conventional extraction methods. Based on the results obtained, we selected the optimal technique for isoflavones isolation. Isoflavones were identified by gas chromatography equipped with mass spectrometer (GC-MS), whereas their quantities were determined using high performance liquid chromatography (HPLC). In vivo metabolism of daidzein to S-equol was performed in rats with quantification of a yield of S-equol as a result of daidzein in vivo conversion in rats’ intestines

Platforms for Promoting a Personal Brand in the Video Production Industry Online

В статье рассматриваются площадки в сети Интернет, с помощью которых специалист в сфере создания видеоконтента может демонстрировать профессиональную деятельность. Поскольку работодатели предпочитают снижать финансовые издержки, в сфере креативных индустрий растет тенденция привлекать фрилансеров для проектной занятости, что приводит к необходимости для специалиста развивать сильный личный бренд. Интернет-платформы — это эффективный и малозатратный инструмент продвижения личного бренда. При выборе площадки учитываются ее преимущества и недостатки, специфика видео-контента, а также особенности поведения целевой аудитории.This article analyzes proper channels through which video content creators can highlight their professional activities. As employers prefer to reduce their financial costs, there is a growing trend in the creative industries to hire freelancers for project employment, that leads to the need for the specialist to build a solid personal brand. Internet platforms are effective and low-cost tool for promoting a personal brand. When choosing a platform, one should take into account its advantages and disadvantages, the specifics of the video content, as well as the characteristics of the target audience’s behavior

Suspended semiconductor nanostructures: physics and technology

The current state of research on quantum and ballistic electron transport in semiconductor nanostructures with a two-dimensional electron gas separated from the substrate and nanoelectromechanical systems is reviewed. These nanostructures fabricated using the surface nanomachining technique have certain unexpected features in comparison to their non-suspended counterparts, such as additional mechanical degrees of freedom, enhanced electron-electron interaction and weak heat sink. Moreover, their mechanical functionality can be used as an additional tool for studying the electron transport, complementary to the ordinary electrical measurements. The article includes a comprehensive review of spin-dependent electron transport and multichannel effects in suspended quantum point contacts, ballistic and adiabatic transport in suspended nanostructures, as well as investigations on nanoelectromechanical systems. We aim to provide an overview of the state-of-the-art in suspended semiconductor nanostructures and their applications in nanoelectronics, spintronics and emerging quantum technologies

Nonequilibrium phenomena in bilayer electron systems

In the present Letter, we have used magnetocapacitance and magnetoresistance measurements to investigate nonequilibrium phenomena in a bilayer electron system based on GaAs/AlGaAs heterostructures. The magnetic field ramping drives the bilayer electron system out of equilibrium, leading to magnetoresistance hysteresis and spikes. Unlike magnetoresistance, magnetocapacitance results intriguingly show hysteresis even when both layers are in the quantum Hall state. The hysteresis is accompanied by interlayer charge transfer, but the disequilibrium is not limited to interlayer imbalance. Results show that the edge-bulk imbalance can be the initial ground for the appearance of hysteresis. In addition, the nonequilibrium states are observed in which the total, rather than individual, layer densities determine the magnetic field and gate voltage dependencies