Interpreting the sub-linear Kennicutt-Schmidt relationship: The case for diffuse molecular gas

Recent statistical analysis of two extragalactic observational surveys strongly indicate a sublinear Kennicutt-Schmidt (KS) relationship between the star formation rate (Sigsfr) and molecular gas surface density (Sigmol). Here, we consider the consequences of these results in the context of common assumptions, as well as observational support for a linear relationship between Sigsfr and the surface density of dense gas. If the CO traced gas depletion time (tau_mol) is constant, and if CO only traces star forming giant molecular clouds (GMCs), then the physical properties of each GMC must vary, such as the volume densities or star formation rates. Another possibility is that the conversion between CO luminosity and Sigmol, the XCO factor, differs from cloud-to-cloud. A more straightforward explanation is that CO permeates the hierarchical ISM, including the filaments and lower density regions within which GMCs are embedded. A number of independent observational results support this description, with the diffuse gas comprising at least 30% of the total molecular content. The CO bright diffuse gas can explain the sublinear KS relationship, and consequently leads to an increasing tau_mol with Sigmol. If Sigsfr linearly correlates with the dense gas surface density, a sublinear KS relationship indicates that the fraction of diffuse gas fdiff grows with Sigmol. In galaxies where Sigmol falls towards the outer disk, this description suggests that fdiff also decreases radially.Comment: 8 pages, 4 figures, to appear in MNRAS, comments welcom

On the temperature structure of the Galactic Centre cloud G0.253+0.016

We present a series of smoothed particle hydrodynamical models of G0.253+0.016 (also known as 'The Brick'), a very dense molecular cloud that lies close to the Galactic Centre. We explore how its gas and dust temperatures react as we vary the strength of both the interstellar radiation field (ISRF) and the cosmic ray ionisation rate (CRIR). As the physical extent of G0.253+0.016 along our line-of-sight is unknown, we consider two possibilities: one in which the longest axis is that measured in the plane of the sky (9.4 pc in length), and one in which it is along the line of sight, in which case we take it to be 17 pc. To recover the observed gas and dust temperatures, we find find that the ISRF must be around 1000 times the solar neighbourhood value, and the CRIR must be roughly 1E-14 /s, regardless of the geometries studied. For such high values of the CRIR, we find that cooling in the cloud's interior is dominated by neutral oxygen, in contrast to standard molecular clouds, which at the same densities are mainly cooled via CO. Our results suggest that the conditions near G0.253+0.016 are more extreme than those generally accepted for the inner 500 pc of the galaxy.Comment: 6 pages, 4 figures, 1 table, accepted for publication in ApJ Letter

Using CO line ratios to trace the physical properties of molecular clouds

The carbon monoxide (CO) rotational transition lines are the most common tracers of molecular gas within giant molecular clouds (MCs). We study the ratio ($R_{2-1/1-0}$) between CO's first two emission lines and examine what information it provides about the physical properties of the cloud. To study $R_{2-1/1-0}$ we perform smooth particle hydrodynamic simulations with time dependent chemistry (using GADGET-2), along with post-process radiative transfer calculations on an adaptive grid (using RADMC-3D) to create synthetic emission maps of a MC. $R_{2-1/1-0}$ has a bimodal distribution that is a consequence of the excitation properties of each line, given that $J=1$ reaches local thermal equilibrium (LTE) while $J=2$ is still sub-thermally excited in the considered clouds. The bimodality of $R_{2-1/1-0}$ serves as a tracer of the physical properties of different regions of the cloud and it helps constrain local temperatures, densities and opacities. Additionally this bimodal structure shows an important portion of the CO emission comes from diffuse regions of the cloud, suggesting that the commonly used conversion factor of $R_{2-1/1-0}\sim 0.7$ between both lines may need to be studied further.Comment: 10 pages, 8 figures, accepted to MNRA

Principal Component Analysis of Molecular Clouds: Can CO reveal the dynamics?

We use Principal Component Analysis (PCA) to study the gas dynamics in numerical simulations of typical MCs. Our simulations account for the non-isothermal nature of the gas and include a simplified treatment of the time-dependent gas chemistry. We model the CO line emission in a post-processing step using a 3D radiative transfer code. We consider mean number densities n_0 = 30, 100, 300 cm^{-3} that span the range of values typical for MCs in the solar neighbourhood and investigate the slope \alpha_{PCA} of the pseudo structure function computed by PCA for several components: the total density, H2 density, 12CO density, 12CO J = 1 -> 0 intensity and 13CO J = 1 -> 0 intensity. We estimate power-law indices \alpha_{PCA} for different chemical species that range from 0.5 to 0.9, in good agreement with observations, and demonstrate that optical depth effects can influence the PCA. We show that when the PCA succeeds, the combination of chemical inhomogeneity and radiative transfer effects can influence the observed PCA slopes by as much as ~ +/- 0.1. The method can fail if the CO distribution is very intermittent, e.g. in low-density clouds where CO is confined to small fragments.Comment: 12 pages, 8 figures, accepted for publication in MNRA

Case Report - Marfan syndrome: Report of two cases with review of literature

Marfan syndrome is a variable, autosomal dominant disorder of connective tissue whose cardinal features affect the cardiovascular system, eyes and skeleton. The minimal birth incidence is around 1 in 9800. About three quarters of patients have an affected parent; new mutations account for the remainder. The patient’s prognosis depends on the severity of cardiovascular complications and is mainly determined by progressive dilation of the aorta. If signs of Marfan syndrome are recognized, it is important to refer to the correct health care professional for further testing to prevent associated complications. If not properly treated, premature death may be caused by the severe cardiovascular and pulmonary complications associated with Marfan syndrome. Therefore, it is important to identify this potentially life‑threatening condition in general practice. This article reports two cases with a very typical features of Marfan syndrome

A case of Guillain-Barre syndrome presenting at third trimester of pregnancy complicated with pre-eclampsia and acute kidney injury

Guillain-Barre syndrome (GBS) is immune mediated injury of the peripheral nerves. This condition can affect any individuals with some trigger. Here the disease affected the lady in her last trimester of pregnancy which was complicated with pre-eclampsia and acute kidney injury. Later she recovered by multimodal treatment approach, with a prolonged intensive care unit stay. Currently she and her baby are stable with frequent follow up. This case highlights the fact that GBS can affect any trimester of pregnancy and her pregnancy could be a trigger. Further, treatment approach involves multiple specialties including internal medicine, nephrologist, neurologist, physiotherapist and psychiatrist

Indications of a sub-linear and non-universal Kennicutt-Schmidt relationship

We estimate the parameters of the Kennicutt-Schmidt (KS) relationship, linking the star formation rate (Sigma_SFR) to the molecular gas surface density (Sigma_mol), in the STING sample of nearby disk galaxies using a hierarchical Bayesian method. This method rigorously treats measurement uncertainties, and provides accurate parameter estimates for both individual galaxies and the entire population. Assuming standard conversion factors to estimate Sigma_SFR and Sigma_mol from the observations, we find that the KS parameters vary between galaxies, indicating that no universal relationship holds for all galaxies. The KS slope of the whole population is 0.76, with the 2sigma range extending from 0.58 to 0.94. These results imply that the molecular gas depletion time is not constant, but varies from galaxy to galaxy, and increases with the molecular gas surface density. Therefore, other galactic properties besides just Sigma_mol affect Sigma_SFR, such as the gas fraction or stellar mass. The non-universality of the KS relationship indicates that a comprehensive theory of star formation must take into account additional physical processes that may vary from galaxy to galaxy.Comment: 7 pages, 2 figures, 1 table. Updated to match MNRAS accepted versio

A questionnaire based survey to evaluate the usage pattern of carbapenems for sepsis management in intensive care unit

Background: Sepsis remains one of the most common critical illnesses for patients to be admitted to an intensive care unit (ICU) and has very high associated morbidity and mortality ranging from 18 to 50%. It is a well-known fact that early goal directed therapy with broad spectrum antibiotics, IV fluids and other supportive therapies improve outcome. The current study was done to know the importance of carbapenems in the management of sepsis focusing on perceived use and the clinical outcome in real time setting in tertiary care hospitals.Methods: A structured questionnaire designed to collect information on the perceived use of carbapenems, the clinical outcome, response period for clinical cure and combination antibiotic therapy preferred with carbapenem was circulated among 50 clinicians in tertiary care hospitals and nursing homes in and around Mangalore between January 2015 to March 2015.Results: Majority of doctors (>80%) felt that carbapenems a broad spectrum antibiotic administration provided good clinical improvement in hospital infections along with improvement in blood cell count and bacteriological cure.Conclusions: Our study provides an important insight regarding the knowledge, practice pattern and clinical outcome through the use of carbapenem in Sepsis management in ICU’s around Mangalore. The experience of practice patterns and clinical outcomes with carbapenem shared by doctors through this survey is similar to that in other studies