Influence of misalignments on performance of externally occulted solar coronagraphs. Application to PROBA-3/ASPIICS

ASPIICS is a novel externally occulted coronagraph that will be launched onboard the PROBA-3 mission of ESA. The external occulter (EO) will be placed on one satellite ~150 m ahead of the second satellite with an optical instrument. During part of each orbit, the satellites will fly in a precise formation, constituting a giant externally occulted coronagraph. Large distance between the EO and the primary objective will allow observations of the white-light solar corona starting already from ~1.1RSun. We analyze influence of shifts of the satellites and misalignments of optical elements on diffracted light. Based on the quantitative influence of misalignments on diffracted light, we will provide a "recipe" for choosing the size of the internal occulter (IO) to achieve a trade-off between the minimal height of observations and sustainability to possible misalignments. We implement a numerical model of the diffracted light and its propagation through the optical system, and compute intensities of diffracted light throughout the instrument. Our numerical model extends axi-symmetrical model of Rougeot et al. 2017 to non-symmetrical cases. The computations fully confirm main properties of the diffracted light obtained from semi-analytical consideration. Results: relative influences of various misalignments are significantly different. We show that: the IO with R=1.1RSun is large enough to compensate possible misalignments in ASPIICS, apodizing the edge of the IO leads to additional suppression of the diffracted light. Conclusions: the most important misalignment is the tilt of the telescope WRT the line connecting the center of the EO and the entrance aperture. Special care should be taken to co-align the EO and the coronagraph, i.e. co-aligning the diffraction fringe from the EO and the IO. We suggest that the best orientation strategy is to point the coronagraph to the center of the EO.Comment: 13 pages, 15 figure

Modeling and removal of optical ghosts in the PROBA-3/ASPIICS externally occulted solar coronagraph

Context: ASPIICS is a novel externally occulted solar coronagraph, which will be launched onboard the PROBA-3 mission of the European Space Agency. The external occulter will be placed on the first satellite approximately 150 m ahead of the second satellite that will carry an optical instrument. During 6 hours per orbit, the satellites will fly in a precise formation, constituting a giant externally occulted coronagraph. Large distance between the external occulter and the primary objective will allow observations of the white-light solar corona starting from extremely low heights 1.1RSun. Aims: To analyze influence of optical ghost images formed inside the telescope and develop an algorithm for their removal. Methods: We implement the optical layout of ASPIICS in Zemax and study the ghost behaviour in sequential and non-sequential regimes. We identify sources of the ghost contributions and analyze their geometrical behaviour. Finally we develop a mathematical model and software to calculate ghost images for any given input image. Results: We show that ghost light can be important in the outer part of the field of view, where the coronal signal is weak, since the energy of bright inner corona is redistributed to the outer corona. However the model allows to remove the ghost contribution. Due to a large distance between the external occulter and the primary objective, the primary objective does not produce a significant ghost. The use of the Lyot spot in ASPIICS is not necessary.Comment: 14 pages, 13 figure

Nonlinear evolution of short-wavelength torsional Alfvén waves

We analyze nonlinear evolution of torsional Alfvén waves in a straight magnetic flux tube filled in with a low-β plasma, and surrounded with a plasma of lower density. Such magnetic tubes model, in particular, a segment of a coronal loop or a polar plume. The wavelength is taken comparable to the tube radius. We perform a numerical simulation of the wave propagation using ideal magnetohydrodynamics. We find that a torsional wave nonlinearly induces three kinds of compressive flows: the parallel flow at the Alfvén speed, which constitutes a bulk plasma motion along the magnetic field, the tube wave, and also transverse flows in the radial direction, associated with sausage fast magnetoacoustic modes. In addition, the nonlinear torsional wave steepens and its propagation speed increases. The latter effect leads to the progressive distortion of the torsional wave front, i.e., nonlinear phase mixing. Because of the intrinsic non-uniformity of the torsional wave amplitude across the tube radius, the nonlinear effects are more pronounced in regions with higher wave amplitudes. They are always absent at the axes of the flux tube. In the case of a linear radial profile of the wave amplitude, the nonlinear effects are localized in an annulus region near the tube boundary. Thus, the parallel compressive flows driven by torsional Alfvén waves in the solar and stellar coronae, are essentially non-uniform in the perpendicular direction. The presence of additional sinks for the wave energy reduces the efficiency of the nonlinear parallel cascade in torsional Alfvén waves

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells.

A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism. The model generated in the bonded cumomer formalism describes key pathways of tumor intermediary metabolism and yields dynamic curves for positional isotopic enrichment and spin-spin multiplets. Cells attached to microcarrier beads were perfused with 26 mm [1,6-(13)C2]glucose under normoxic conditions at 37 °C and monitored by (13)C NMR spectroscopy. Excellent agreement between model-predicted and experimentally measured values of the rates of oxygen and glucose consumption, lactate production, and glutamate pool size validated the model. ATP production by glycolytic and oxidative metabolism were compared under hyperglycemic normoxic conditions; 51% of the energy came from oxidative phosphorylation and 49% came from glycolysis. Even though the rate of glutamine uptake was ∼50% of the tricarboxylic acid cycle flux, the rate of ATP production from glutamine was essentially zero (no glutaminolysis). De novo fatty acid production was ∼6% of the tricarboxylic acid cycle flux. The oxidative pentose phosphate pathway flux was 3.6% of glycolysis, and three non-oxidative pentose phosphate pathway exchange fluxes were calculated. Mass spectrometry was then used to compare fluxes through various pathways under hyperglycemic (26 mm) and euglycemic (5 mm) conditions. Under euglycemic conditions glutamine uptake doubled, but ATP production from glutamine did not significantly change. A new parameter measuring the Warburg effect (the ratio of lactate production flux to pyruvate influx through the mitochondrial pyruvate carrier) was calculated to be 21, close to upper limit of oxidative metabolism

Геотермические условия газонефтеводоносных комплексов Пермско-Башкирского свода в пределах Пермского края

Интерес к геотермическим исследованиям обусловлен общепризнанным значением температуры недр как важнейшего фактора нефтегазообразования, миграции и преобразований подземных флюидов, как одного из важных показателей распределения естественных и искусственных тепловых свойств пород по площади и с глубиной. На территории Пермского края в пределах Пермско-Башкирского свода геотермические исследования осадочного разреза проведены на 251 площади. Рассмотрены особенности изменения геотермических условий с глубиной и по площади. Проведен сравнительный анализ геотермических показателей исследованных площадей: температуры, геотермического градиента, геотермической ступени. По геотермическим показателям выявлены перспективные площади на нефть и газ.</p

Short-Period Internal Waves under an Ice Cover in Van Mijen Fjord, Svalbard

Temperature and velocity fluctuations measured in Van Mijen Fjord in Svalbard and interpreted as the fluctuations induced by internal waves revealed the existence of short-period internal waves with an amplitude of approximately 1 m and a period of approximately 5–10 min that correlate with the ice cover fluctuations of the same period with an amplitude of a few millimeters

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its anaplerotic pathways, pyruvate-malate shuttling, glutaminolysis, and fatty acid biosynthesis and oxidation. The model that is called Bonded Cumomer Analysis for application to (13)C magnetic resonance spectroscopy ((13)C MRS) data and Fragmented Cumomer Analysis for mass spectrometric data is a refined and efficient form of isotopomer analysis that can readily be expanded to incorporate glycogen, phospholipid, and other pathways thereby encompassing all the key pathways of tumor intermediary metabolism. Validation was achieved by demonstrating agreement of experimental measurements of the metabolic rates of oxygen consumption, glucose consumption, lactate production, and glutamate pool size with independent measurements of these parameters in cultured human DB-1 melanoma cells. These cumomer models have been applied to studies of DB-1 melanoma and DLCL2 human diffuse large B-cell lymphoma cells in culture and as xenografts in nude mice at 9.4 T. The latter studies demonstrate the potential translation of these methods to in situ studies of human tumor metabolism by MRS with stable (13)C isotopically labeled substrates on instruments operating at high magnetic fields (≥7 T). The melanoma studies indicate that this tumor line obtains 51% of its ATP by mitochondrial metabolism and 49% by glycolytic metabolism under both euglycemic (5 mM glucose) and hyperglycemic conditions (26 mM glucose). While a high level of glutamine uptake is detected corresponding to ~50% of TCA cycle flux under hyperglycemic conditions, and ~100% of TCA cycle flux under euglycemic conditions, glutaminolysis flux and its contributions to ATP synthesis were very small. Studies of human lymphoma cells demonstrated that inhibition of mammalian target of rapamycin (mTOR) signaling produced changes in flux through the glycolytic, pentose shunt, and TCA cycle pathways that were evident within 8 h of treatment and increased at 24 and 48 h. Lactate was demonstrated to be a suitable biomarker of mTOR inhibition that could readily be monitored by (1)H MRS and perhaps also by FDG-PET and hyperpolarized (13)C MRS methods

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and statistical simulations. We identified and confirmed a novel mode of regulation specific to aerobic glycolysis where flux through GAPDH, the enzyme separating lower and upper glycolysis, is the rate-limiting step in the pathway and the levels of fructose (1,6) bisphosphate (FBP), are predictive of the rate and control points in glycolysis. Strikingly, negative flux control was found and confirmed for several steps thought to be rate-limiting in glycolysis. Together, these findings enumerate the biochemical determinants of the WE and suggest strategies for identifying the contexts in which agents that target glycolysis might be most effective. DOI: http://dx.doi.org/10.7554/eLife.03342.00

LUCI onboard Lagrange, the Next Generation of EUV Space Weather Monitoring

LUCI (Lagrange eUv Coronal Imager) is a solar imager in the Extreme UltraViolet (EUV) that is being developed as part of the Lagrange mission, a mission designed to be positioned at the L5 Lagrangian point to monitor space weather from its source on the Sun, through the heliosphere, to the Earth. LUCI will use an off-axis two mirror design equipped with an EUV enhanced active pixel sensor. This type of detector has advantages that promise to be very beneficial for monitoring the source of space weather in the EUV. LUCI will also have a novel off-axis wide field-of-view, designed to observe the solar disk, the lower corona, and the extended solar atmosphere close to the Sun-Earth line. LUCI will provide solar coronal images at a 2-3 minute cadence in a pass-band centred on 19.5 nm. Observations made through this pass-band allow for the detection and monitoring of semi-static coronal structures such as coronal holes, prominences, and active regions; as well as transient phenomena such as solar flares, limb Coronal Mass Ejections (CMEs), EUV waves, and coronal dimmings. The LUCI data will complement EUV solar observations provided by instruments located along the Sun-Earth line such as PROBA2-SWAP, SUVI-GOES and SDO-AIA, as well as provide unique observations to improve space weather forecasts. Together with a suite of other remote-sensing and in-situ instruments onboard Lagrange, LUCI will provide science quality operational observations for space weather monitoring