Strain-induced insulator state in La_0.7Sr_0.3CoO_3

We report on the observation of a strain-induced insulator state in ferromagnetic La_0.7Sr_0.3CoO_3 films. Tensile strain above 1% is found to enhance the resistivity by several orders of magnitude. Reversible strain of 0.15% applied using a piezoelectric substrate triggers huge resistance modulations, including a change by a factor of 10 in the paramagnetic regime at 300 K. However, below the ferromagnetic ordering temperature, the magnetization data indicate weak dependence on strain for the spin state of the Co ions. We interpret the changes observed in the transport properties in terms of a strain-induced splitting of the Co e_g levels and reduced double exchange, combined with a percolation-type conduction in an electronic cluster state

Gross Brain Morphology in the Yellow Stingray, Urobatis jamaicensis

The yellow stingray, Urobatis jamaicensis (family Urolophidae), a short-lived, relatively small elasmobranch species (35--40 cm total length), is a common inhabitant of hard bottom and coral reef communities in southeastern Florida and many parts of the Caribbean. A paucity of published studies deal with the yellow stingray, none however on the gross morphology of its nervous system. The gross brain structure of the yellow stingray is compared with previously published studies on other batoid elasmobranchs. The external brain structure of Urobatis jamaicensis was similar to that reported for other Dasyatids, including presence of an asymmetric cerebellum. The bilaterally symmetric brain is well developed and quite large in proportion to body size (≈1--2% bw). Stingrays generally possess a brain three to 10 times the size of their sister groups, the electric rays, guitarfish, and skates (Northcutt, 1989), the yellow stingray is no exception

Reversible strain effect on the magnetization of LaCoO3 films

The magnetization of ferromagnetic LaCoO3 films grown epitaxially on piezoelectric substrates has been found to systematically decrease with the reduction of tensile strain. The magnetization change induced by the reversible strain variation reveals an increase of the Co magnetic moment with tensile strain. The biaxial strain dependence of the Curie temperature is estimated to be below 4K/% in the as-grown tensile strain state of our films. This is in agreement with results from statically strained films on various substrates

Pupillometry, a bioengineering overview

The pupillary control system is examined using a microprocessor based integrative pupillometer. The real time software functions of the microprocessor include: data collection, stimulus generation and area to diameter conversion. Results of an analysis of linear and nonlinear phenomena are presented

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity. Here, we investigated the role of glial cells in the peripheral nervous system by creating SMA mice selectively overexpressing SMN in myelinating Schwann cells (Smn(−/−);SMN2(tg/0);SMN1(SC)). Restoration of SMN protein levels restricted solely to Schwann cells reversed myelination defects, significantly improved neuromuscular function and ameliorated neuromuscular junction pathology in SMA mice. However, restoration of SMN in Schwann cells had no impact on motor neuron soma loss from the spinal cord or ongoing systemic and peripheral pathology. This study provides evidence for a defined, intrinsic contribution of glial cells to SMA disease pathogenesis and suggests that therapies designed to include Schwann cells in their target tissues are likely to be required in order to rescue myelination defects and associated disease symptoms