3,689 research outputs found
Monomer diffusion rates in photopolymer material: Part I. Low spatial frequency holographic gratings: reply
In [1,2] an error (by a factor of 1000) in the diffusion rate of monomer in a photopolymer material used by the
authors of [3], is presented. In [3] no errors are identified in our analysis and our physical evidence is not addressed.
It is implied that our model and our results are disproven by the results in the papers referenced in
[3]. In fact these papers do not provide any such quantitative evidence. The observations made regarding the significance
of the authors’ contributions, in particular the validity of their model and the practical importance of
their material are also discussed. © 2012 Optical Society of Americ
Dispersion relations for circular single and double dusty plasma chains
We derive dispersion relations for a system of identical particles confined
in a two-dimensional annular harmonic well and which interact through a Yukawa
potential, e.g., a dusty plasma ring. When the particles are in a single chain
(i.e., a one-dimensional ring) we find a longitudinal acoustic mode and a
transverse optical mode which show approximate agreement with the dispersion
relation for a straight configuration for large radii of the ring. When the
radius decreases, the dispersion relations modify: there appears an
anticrossing of the modes near the crossing point resulting in a frequency gap
between the lower and upper branches of the modified dispersion relations. For
the double chain (i.e., a two-dimensional zigzag configuration) the dispersion
relation has four branches: longitudinal acoustic and optical and transverse
acoustic and optical.Comment: 10 pages, 8 fugure
Collisional Plasma Sheath Model
The effects of ion collisionality on the plasma sheath are revealed by a two-fluid model. In contrast to previous work, the ion-neutral collision cross section is modeled using a power law dependence on ion energy. Exact numerical solutions of the model are used to determine the collisional dependence of the sheath width and the ion impact energy at the wall. Approximate analytical solutions appropriate for the collisionless and collisionally dominated regimes are derived. These approximate solutions are used to find the amount of collisionality at the center of the transition regime separating the collisionless and collisional regimes. Rx-the constant ion mean-free-path case, the center of the transition regime for the sheath width is at a sheath width of five mean-free paths. The center of the transition regime for the ion impact energy is at a sheath width of about one-half of a mean-free path
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Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.
BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. OBJECTIVES: The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. DESIGN: Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). SETTING: Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. PARTICIPANTS: Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. INTERVENTIONS: No interventions were performed. MAIN OUTCOME MEASURES: (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. RESULTS: A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). LIMITATIONS: Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. CONCLUSIONS: We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. FUTURE WORK: A large case-control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information
Eulerian simulation of the fluid dynamics of helicopter brownout
A computational model is presented that can be used to simulate the development of the dust cloud
that can be entrained into the air when a helicopter is operated close to the ground in desert or dusty
conditions. The physics of this problem, and the associated pathological condition known as ‘brownout’
where the pilot loses situational awareness as a result of his vision being occluded by dust suspended in the
flow around the helicopter, is acknowledged to be very complex. The approach advocated here involves
an approximation to the full dynamics of the coupled particulate-air system. Away from the ground, the
model assumes that the suspended particles remain in near equilibrium under the action of aerodynamic
forces. Close to the ground, this model is replaced by an algebraic sublayer model for the saltation and
entrainment process. The origin of the model in the statistical mechanics of a distribution of particles
governed by aerodynamic forces allows the validity of the method to be evaluated in context by comparing
the physical properties of the suspended particulates to the local properties of the flow field surrounding
the helicopter. The model applies in the Eulerian frame of reference of most conventional Computational
Fluid Dynamics codes and has been coupled with Brown’s Vorticity Transport Model. Verification of the
predictions of the coupled model against experimental data for particulate entrainment and transport in
the flow around a model rotor are encouraging. An application of the coupled model to analyzing the
differences in the geometry and extent of the dust clouds that are produced by single main rotor and
tandem-rotor configurations as they decelerate to land has shown that the location of the ground vortex
and the size of any regions of recirculatory flow, should they exist, play a primary role in governing the
extent of the dust cloud that is created by the helicopter
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