Competitiveability of businesses in terms of dynamic changes of external environment

В статье автор рассматривает ретроспективу изменения условий конкуренции и трансформации бизнеса, обеспечивающие конкурентоспособность компаний на каждом этапе развития экономики. В работе приводится классификация конкурентных преимуществ компаний, выявляются новые направления и подходы к обеспечению на современном этапе.The author in the article considers retrospective of competitive environment changes and business transformations which provide competitive ability of companies at every step of economy development. Classification of competitive advantages of businesses is reproduced in the article. New directions and approaches to provide competitive advantages at the modern stage are found

The analysis of an electrocardiosignal in a system of data transmission in control office

Among the reasons of accidents on roads there is drivers' drowsiness. So, it is very important to develop a system that detects an approach of drowsiness and awakes a driver in a case of alarm. The method of detection of drowsiness based on analysis of ECG parameters is convenient and informative enough. A problem of monitoring a driver's state by controlling his heart rate is actual because this parameter is simple to register. But a threshold of drowsiness can vary for different people. So, it is necessary to control some additional parameters.Research of how parameters of heart rate variability (LF/HF and index of stress of Bayevsky) change in time depending on a state person (during wakefulness, drowsiness and stress) has been carried out. The results showed that there are certain intervals of values characterizing each kind of state. To sum up, it's suggested to use the analysis of three ECG parameters (HR, LF/HF and index of stress of Bayevsky) in drivers' drowsiness detecting systems. Using a GPRS data transmission system allows to realize processing and storage of ECG information on a powerful server

Cardiac arrhythmia analysis used in the system of electrocardiosignal transmission to the supervision center

In the paper, we consider an algorithm for analyzing a person's heart condition. This algorithm is intended for systems of wireless electrocardiosignal transfer to the supervision and analysis center. Such systems are very useful when it is necessary to promptly estimate condition and operation work of the heart. Thus, more thorough analysis can be carried out later.These systems can be successfully used in medicine of accidents (ministry of emergency rescue) while evaluating condition of vehicle drivers, of sportsmen during training, of people at home.It is especially important to detect various kinds of cardiac arrhythmias at early stages. In our work, we have developed the block diagram of algorithm detecting the basic kinds of cardiac arrhythmias using logical formulae

LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT) and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP) monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree

LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT) and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP) monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree.</p

NEW PERSPECTIVES OF DIPYRIDAMOL USAGE IN TREATMENT OF CORONARY HEART DISEASE

There is a great number of coronary patients to whom traditional methods of myocardium revascularization are not indicated. Addition of dipyridamol to traditional antianginal treatment promotes improvement of clinical features of the disease and decreased functional class of angina in coronary patients. The usage of dipyridamol for 3 months was accompanied by increased physical stress tolerance threshold, increased time of physical stress, decreased asynergy areas on echo ate peak stress, suggesting possible angiogenesis in myocardium hypoperfusion areas in the region of stenotic coronary artery

Associations of polyphenolic compounds consumption and the risk of dyslipidemia in the Siberian population

Aim. To identify associations of polyphenols consumption in general, as well as their classes with the risk of dyslipidemia in the population of Novosibirsk aged 45-69.Material and methods. In 2003-2005, in the frames of the HAPIEE international project “Determinants of cardiovascular diseases in Eastern Europe: a multicenter cohort study” the population sample aged 45-69 (9360 people, 4266 men and 5094 women, average age - 57.6 years) was examined in Novosibirsk. For the analysis of nutrition, a Food Frequency Questionnaire (FFQ) was used (141 product names). The content of polyphenolic compounds and their classes was evaluated using the European database Phenol-Explorer 3.6. The eating habits of the population and typically consumed foods were taken into account. The determination of total cholesterol and HDL cholesterol levels were carried out by enzymatic method. Hypercholesterolemia was diagnosed with cholesterol level greater than 5.0 mmol/l (190 mg/dL). Levels of HDL cholesterol &lt;1.0 mmol/l in men and &lt;1.2 mmol/l in women were considered as high-density lipoprotein hypocholesterolemia (hypoHDL-C). The concentration of low-density lipoprotein cholesterol was calculated with the Friedewald formula (1972). HyperLDL-C was diagnosed if level of LDL cholesterol was &lt;3.0 mmol / l.Results. The chance of developing of hypercholesterolemia in the quartile with the highest consumption of “other polyphenols” was 20% less (OR 1.2 confidence interval (CI 1.01-0.14), p = 0.033), phenolic acids by 20% (OR 1.2 (CI 1.01-1.42), p = 0.04) and stilbenes by 37% (OR 1.37 (CI 1.15-1.64), p = 0.001) less than in the quartile of low consumption. The risk of developing hypoHDL-C was lower in the quartile of high polyphenols consumption in general by 18% (OR 1.18 (CI 1.002-1.4), p = 0.051), phenolic acids by 32% (OR 1.32 (CI 1.11-1.57), p = 0.001) and the groups of “other polyphenols” by 20% (OR 1.2 (CI 1.01-1.41), p = 0.04). The chance of hyperLDL-C in the high quartile of consumption of “other polyphenols” decreased by 16% (OR 1.16 (CI 1.002-1.355), p = 0.049) and lignans - by 33% (OR 1.33 (CI 1.14-1, 56), p &lt;0.001) compared with low consumption.Conclusion. Thus, the consumption of polyphenols in general and in classes (phenolic acids, stilbenes, and “other polyphenols”) decreased the risk of dyslipidemia in Siberian population